NSF Postdoctoral Fellowship in Biology FY 2020: Development and Evolution of Olfactory Perception in Response to Temperature

2020 财年 NSF 生物学博士后奖学金：嗅觉感知对温度的反应的发展和演变

• 批准号: 2010782
• 负责人: Robert Mobley
• 金额: $ 13.8万
• 依托单位: Mobley, Robert
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2010782&HistoricalAwards=false
• 关键词: NSF; Postdoctoral; Fellowship; Biology; FY

This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2020, Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, Environment and Phenotypes. The fellowship supports research and training of the fellow that will contribute to the area of Rules of Life in innovative ways. The project will examine gene expression, brain structure, and behavior of fish raised under different thermal conditions. The fellow will conduct research to investigate how temperature experienced during development affects brain development, which will provide an understanding of how organisms maintain or alter reproductive behaviors in the face of global climate change. Environmental temperatures alter the expression of genes, and can change how organisms grow and develop. The project will also assess the potential for evolutionary pressures to act upon different genes that respond to changing temperatures. The work will provide the fellow training in molecular, physiological and bioinformatic techniques, as well as professional development in the life sciences. The project will provide research opportunities to many underrepresented undergraduate students at a public university, and the fellow will take part in outreach activities designed to engage girls and underrepresented minority students in STEM fields. This project will explore relationships between temperature and development of the brain, by measuring the growth and function of olfactory processing centers throughout development. Expression of the sonic hedgehog gene regulates the dorsal-ventral patterning of vertebrate brain regions during development, which may impact an organism's fitness by altering sensory processing. Temperature is a pervasive part of the environment, capable of influencing many developmental processes and expected to change around the world in years to come. The fellow will generate reaction norms of sonic hedgehog expression during development under different ecologically relevant temperatures and quantify effects on neuroanatomy. The life long-consequences of these temperature effects will be evaluated by behaviorally and physiologically measuring the detection of socially relevant olfactory stimuli in different parts of the telencephalon of the adult organism. The project will also measure differential expression of the entire transcriptome under different temperatures and use phylogenetic analysis to explore the potential for evolutionary processes to provide supplemental, or alternative, methods of response to temperature. The fellow will be trained in front-line biological techniques to expand their research abilities and generate public outreach through educational experiences and online dissemination. The project bears societal implications for biodiversity and conservation management in response to global climate change. To broaden the impact of the work, the fellow will engage students from underrepresented groups in the research and conduct outreach to girls to increase participation in STEM.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项行动资助了2020财年的NSF生物学博士后研究奖学金，综合研究调查了基因组，环境和表型之间的生命相互作用的规则。该研究金支持研究员的研究和培训，以创新的方式为生活规则领域做出贡献。该项目将研究在不同温度条件下饲养的鱼类的基因表达、大脑结构和行为。该研究员将进行研究，以调查发育过程中经历的温度如何影响大脑发育，这将有助于了解生物体在全球气候变化面前如何维持或改变生殖行为。环境温度会改变基因的表达，并改变生物体的生长和发育方式。该项目还将评估进化压力作用于不同基因的潜力，这些基因对温度变化做出反应。 这项工作将为研究员提供分子、生理和生物信息技术方面的培训，以及生命科学方面的专业发展。该项目将为公立大学中许多代表性不足的本科生提供研究机会，该研究员将参加旨在吸引STEM领域女孩和代表性不足的少数民族学生的外联活动。该项目将通过测量整个发育过程中嗅觉处理中心的生长和功能来探索温度与大脑发育之间的关系。音刺猬基因的表达调节脊椎动物大脑区域在发育过程中的背腹模式，这可能会通过改变感觉处理来影响生物体的适应性。温度是环境的一个普遍组成部分，能够影响许多发育过程，并预计在未来几年内在世界各地发生变化。该研究员将在不同生态相关温度下产生发育过程中音刺猬表达的反应规范，并量化对神经解剖学的影响。这些温度效应的终身后果将通过在成年生物体端脑的不同部分中对社会相关嗅觉刺激的检测进行行为学和生理学测量来评估。该项目还将测量不同温度下整个转录组的差异表达，并使用系统发育分析来探索进化过程的潜力，以提供对温度反应的补充或替代方法。研究员将接受一线生物技术培训，以扩大其研究能力，并通过教育经验和在线传播开展公共外联活动。该项目对应对全球气候变化的生物多样性和保护管理具有社会影响。为了扩大工作的影响，该研究员将吸引来自代表性不足的群体的学生参与研究，并对女孩进行外联，以增加STEM的参与。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。