SBIR Phase I: Fast and scalable printing of high-resolution microfluidic devices using HLP technology.

SBIR 第一阶段：使用 HLP 技术快速、可扩展地打印高分辨率微流体装置。

• 批准号: 2013942
• 负责人: Zheng Xiong
• 金额: $ 22.46万
• 依托单位: 3D MICROFLUIDICS LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2021-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2013942&HistoricalAwards=false
• 关键词: SBIR; Phase; Fast; scalable; printing

The broadder impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to advance the development of microfluidic devices for life sciences research. Currently, devices with high-resolution microchannels are typically manufactured using sophisticated cleanroom microfabrication facilities, requiring technical expertise, high costs, and long turnaround times; these factors inhibit their use. This project will enable rapid manufacturing of customized microfluidics devices with substantially lower costs and turnaround times. This technology will impact research in applications including fundamental cell biology, drug screening, cellular therapy, toxicity testing, and tissue engineering.This SBIR Phase I project will advance the translation of hybrid laser printing (HLP), combining the quick and large-scale printing capability of Continuous Liquid Interface Production (CLIP) with precision processing of additive multiphoton polymerization (MPP) and subtractive multiphoton ablation (MPA) into a single versatile machine. Technical challenges in material discovery and scalability will be addressed in this work: 1) Discover new materials not only compatible with HLP process but also showing the necessary durability, transparency, biocompatibility, and impermeability to fluids; and characterize key HLP parameters, such as ablation z-range used in MPA mode and dead-zone thickness used in CLIP mode; and 2) Scale the maximum printable size of HLP process using a novel multiscale CLIP strategy combined with a step-stitch projection printing method. The project will develop a prototype for life sciences applications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业创新研究（SBIR）第一阶段项目的更广泛影响/商业潜力是推进用于生命科学研究的微流体设备的开发。目前，具有高分辨率微通道的装置通常使用复杂的洁净室微制造设施制造，需要技术专长、高成本和长周转时间;这些因素抑制了它们的使用。该项目将使定制的微流体设备的快速制造，大大降低成本和周转时间。该技术将影响基础细胞生物学、药物筛选、细胞治疗、毒性测试和组织工程等应用领域的研究。SBIR第一阶段项目将推进混合激光打印（HLP）的转化，将连续液体界面生产（CLIP）的快速和大规模打印能力与加性多光子聚合（MPP）和减性多光子烧蚀（MPA）整合成一台多功能机器。本工作将解决材料发现和可扩展性方面的技术挑战：1）发现不仅与HLP工艺兼容，而且显示出必要的耐久性、透明度、生物相容性和不渗透性的新材料;并表征关键HLP参数，例如MPA模式中使用的消融z范围和CLIP模式中使用的死区厚度; 2）采用一种新的多尺度CLIP策略结合分步拼接投影打印方法，实现了HLP工艺的最大可打印尺寸的缩放。该项目将为生命科学应用开发一个原型。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。