SBIR Phase I: Mimicking Metatarsophalangeal Joints Using Tailored Ultra-Dissipative Liquid-Crystalline Elastomers to Treat Hallux Rigidus

SBIR 第一阶段：使用定制的超耗散液晶弹性体模仿跖趾关节治疗拇趾僵硬

• 批准号: 2014661
• 负责人: Amir Torbati
• 金额: $ 22.5万
• 依托单位: IMPRESSIO INC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2014661&HistoricalAwards=false
• 关键词: SBIR; Phase; Mimicking; Metatarsophalangeal; Joints

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to treat arthritis in joints. This project will advance the use of special materials for joint repair, which permit devices to mimic the naturally soft tissues of the body and provide anatomically correct support. These materials also offer the advantages of minimally invasive surgery, development of patient-specific devices. It will offer the ability to arthritis in joints in the foot, hand, knee (e.g. total knee replacement), spine (e.g. total disc replacement), and repair of any load-bearing orthopedic tissue, such as meniscus.The proposed project focuses on advancing the translation of Liquid-Crystalline Elastomers (LCE) as a cartilage replacement device for the metatarsophalangeal (MTP) joint to treat hallux rigidus. Hallux rigidus is a joint disorder at the base of the big toe. This project will be the first to investigate LCEs for orthopedic applications and develop an MTP joint repair using LCEs. LCEs have vastly superior energy dissipation properties relative to traditional elastomers, such as silicone or hydrogels. This project will demonstrate LCEs for treatment of degenerated joints by drawing from the disciplines of liquid-crystal elastomer science, viscoelasticity, and bioengineering. LCEs are known for behavior that is similar to biological tissues. This proposed project will accomplish: 1) synthesizing an LCE to mimic mechanical properties of natural joint to minimize wear rate under simulated physiological conditions; and 2) validation of biomechanical performance and biocompatibility of LCEs in comparison to the state of practice.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业创新研究（SBIR）第一阶段项目的更广泛的影响/商业潜力是治疗关节关节炎。该项目将推进关节修复中特殊材料的使用，使设备能够模仿人体的自然软组织，并提供解剖学上正确的支撑。这些材料还提供了微创手术的优势，开发了针对患者的设备。它可以治疗足、手、膝（如全膝关节置换术）、脊柱（如全椎间盘置换术）关节关节炎，以及修复任何承重的骨科组织，如半月板。该项目的重点是推进液晶弹性体（LCE）作为跖趾关节（MTP）软骨替代装置的转化，以治疗拇趾僵硬。拇僵直是一种在大脚趾底部的关节紊乱。该项目将首次研究LCEs在骨科中的应用，并利用LCEs开发MTP关节修复技术。与传统弹性体（如硅树脂或水凝胶）相比，LCEs具有优越的能量耗散性能。本项目将从液晶弹性体科学、粘弹性和生物工程等学科出发，展示LCEs治疗关节退行性变的方法。lce的行为与生物组织相似。本项目将完成：1)在模拟生理条件下，合成模拟天然关节力学性能的LCE，以最大限度地减少磨损率；2)验证LCEs的生物力学性能和生物相容性与实践状态的比较。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。