SBIR Phase I: Hemorrhagic Stroke Detection with Electrochemical Impedance Spectroscopy ;

SBIR 第一阶段：利用电化学阻抗谱检测出血性中风；

• 批准号: 2014760
• 负责人: Dan Willis
• 金额: $ 22.44万
• 依托单位: Forest Devices, Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2021-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2014760&HistoricalAwards=false
• 关键词: SBIR; Phase; Hemorrhagic; Stroke; Detection

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to investigate an affordable prehospital hemorrhagic stroke (HS) detection device. The current state-of-the-art technology for prehospital HS detection is a computed tomography ambulance (i.e. mobile stroke unit). Mobile stroke units have high upfront and operating costs, and a lower-cost device could revolutionize healthcare for stroke patients in two ways. First, prehospital identification allows these patients to be triaged to hospitals equipped to treat them (neurosurgical centers), resulting in faster care and better outcomes. Second, the ability to rule out HS prehospital will allow earlier treatment of another condition, ischemic stroke, to improve outcomes and reduce long-term healthcare costs. The proposed SBIR Phase I project will use electrochemical impedance spectroscopy (EIS) to differentiate HS and ischemic stroke. EIS involves injecting an alternating current signal and measuring the resulting impedance across a spectrum of frequencies. The impedance spectrum of materials often differ, allowing EIS to be useful in a variety of applications including examination of corrosion, antibody binding, body composition, and disease diagnosis. This work will advance the use of EIS, to date used experimentally in detecting intracranial pathologies, to detect hemorrhagic tissue within the brain. This work will explore the development of a fast-acquisition EIS HS detection device.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）I期项目的更广泛的影响/商业潜力是调查负担得起的院前出血前中风（HS）检测装置。院前HS检测的当前最新技术是计算机断层扫描救护车（即移动中风单元）。移动冲程单元的前期和运营成本很高，低成本设备可以通过两种方式彻底改变中风患者的医疗保健。 首先，院前识别允许将这些患者分为能够治疗这些患者（神经外科中心），从而获得更快的护理和更好的结果。其次，排除HS前院前的能力将允许对另一种疾病（缺血性中风）进行早期治疗，以改善预后并降低长期医疗保健成本。提出的SBIR I期项目将使用电化学阻抗光谱（EIS）来区分HS和缺血性中风。 EIS涉及注入交替的电流信号，并测量频率范围内产生的阻抗。材料的阻抗范围通常会有所不同，从而使EIS在各种应用中有用，包括检查腐蚀，抗体结合，身体组成和疾病诊断。这项工作将推动EIS的使用，迄今为止在检测颅内病理学的实验中使用，以检测大脑内的出血组织。这项工作将探讨快速进取的EIS HS检测设备的开发。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响标准，被认为值得通过评估来获得支持。