SBIR Phase I: A multi-armed and customizable polymer adhesive for expending lifetimes of active ingredients in topical products

SBIR 第一阶段：一种多臂且可定制的聚合物粘合剂，用于延长外用产品中活性成分的使用寿命

• 批准号: 2014765
• 负责人: Michael Invernale
• 金额: $ 22.5万
• 依托单位: HOUR 72, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2021-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2014765&HistoricalAwards=false
• 关键词: SBIR; Phase; multi; armed; customizable

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project will develop a new solution to help prevent insect-borne diseases, such as malaria, Zika, dengue, and chikungunya. Over half the world’s population is at risk of contracting an insect-borne disease, and the global mosquito repellent market is expected to grow to $11 billion by 2021. Use of personal repellents is a promising solution to prevent insect-borne diseases, but challenges include adherence because products may only be effective for a few hours (and less when rubbed or washed off). The proposed technology is a material to serve as a platform for insect repellents in a costly and effective fashion. The proposed material enables ultra-long-lasting efficacy and will be customizable, waterproof, not absorbed into the bloodstream, and imperceptible to the touch when applied to the skin. The technology could be extended to other applications, such as antimicrobial use and sunscreen. This SBIR Phase I project proposes to develop a platform technology to extend the life of functional skin products. Phase I aims are to: 1) Optimize a skin formulation for repelling insects with performance goals: 99%+ efficacy for at least 3 days, waterproof, not absorbed into the bloodstream, containing zero synthetic repellents, and imperceptible to touch when applied to skin; 2) Explore the parameter space for manufacturing the polymer and insect repellent formulation at scale; 3) Conduct testing to determine efficacy of the insect repellent formulation compared to a reference formulation; 4) Demonstrate extended life of a variety of active ingredients for utilization in topical sunscreen and antimicrobial products. Phase I work will establish feasibility of the proposed platform, while meeting a recognized need in the area of protection from vector-borne illnesses.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业创新研究（SBIR）项目的更广泛的影响/商业潜力将开发一种新的解决方案，以帮助预防虫媒疾病，如疟疾，寨卡，登革热和基孔肯雅热。世界上超过一半的人口面临感染虫媒疾病的风险，预计到2021年，全球驱蚊剂市场将增长到110亿美元。使用个人驱虫剂是预防虫媒疾病的一种有希望的解决方案，但挑战包括坚持，因为产品可能只在几个小时内有效（擦或洗掉时更短）。所提出的技术是一种以昂贵而有效的方式作为驱虫剂平台的材料。所提出的材料能够实现超持久的功效，并且将是可定制的，防水的，不会被吸收到血液中，并且当应用于皮肤时触摸不到。 该技术可以扩展到其他应用，如抗菌剂和防晒霜。SBIR第一阶段项目旨在开发一种平台技术，以延长功能性皮肤产品的寿命。第一阶段的目标是：1）以性能目标优化用于驱除昆虫的皮肤制剂：99%+功效持续至少3天，防水，不吸收到血流中，不含合成驱虫剂，并且当施用于皮肤时触摸不到; 3）进行测试以确定驱虫剂制剂与参比制剂相比的功效; 4）证明用于局部防晒和抗微生物产品的各种活性成分的寿命延长。第一阶段的工作将确定拟议平台的可行性，同时满足在保护免受病媒传播疾病领域的公认需求。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。