STTR Phase I: Use of Hydroxycinnamic Acids and Their Oligomers as Substitutes for Synthetic Growth Promoting Supplements in Livestock Feeds

STTR 第一阶段：使用羟基肉桂酸及其低聚物作为牲畜饲料中合成促生长补充剂的替代品

• 批准号: 2015010
• 负责人: Rajai Atalla
• 金额: $ 22.5万
• 依托单位: Cellulose Sciences International
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2022-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2015010&HistoricalAwards=false
• 关键词: STTR; Phase; Use; Hydroxycinnamic; Acids

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is to enhance the health of livestock without addition of synthetic antibiotic and antioxidant compounds. The proposed technologies are corn kernel fiber byproducts of ethanol production from corn. The need for such compounds has grown as livestock is now more often raised in concentrated animal feeding operations that confine animals and result in abnormal oxidative stress. The program is based on extracting these naturally occurring compounds from agricultural residues. These extracts can be used in place of antibiotics and synthetic supplements currently in livestock feeds. The process proposed will enable production at a cost competitive with synthetic supplements.This STTR project proposes to assess the biological activity of hydroxy cinnamic acids and their oligomers (HCAs) as beneficial supplements in livestock feed. They are ester-linked to a hemicellulose known to occur in seed crop brans. The linkage is hydrolyzed during pretreatment of corn bran fiber to prepare it for conversion to ethanol and the HCAs dissolve in the pretreatment solution. As free acids they recover their character, which includes antimicrobial, anti-inflammatory and antioxidant properties. The project will provide kilogram quantities of HCAs for use in feeding trials with young swine, wherein they will be compared with naturally sourced feed supplements currently in use in Europe, as well as un-supplemented feed. Components of the extract will be identified and comprehensive biochemical analyses performed, including study of the gastrointestinal physiology and intestinal permeability. Studies will also be performed of gut microbiomes and how the processes involved are influenced by substitution of HCAs as the primary feed supplement. Successful completion of these studies will provide a basis for more comprehensive studies of the use of HCAs as supplements in the diet of other livestock.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小型企业技术转移（STTR）项目的更广泛的影响/商业潜力是增强牲畜的健康，而不添加合成抗生素和抗氧化剂化合物。提出的技术是玉米乙醇生产的玉米核纤维副产品。这种化合物的需求已增加，因为现在牲畜更经常在限制动物并导致异常氧化应激的浓缩动物喂养手术中提出。该程序基于从农业残留物中提取这些天然存在的化合物。 这些提取物可以代替牲畜饲料中目前的抗生素和合成补充剂。 提出的过程将使与合成补充剂具有成本竞争的生产。该STTR项目提议评估羟基肉桂酸及其低聚物（HCAS）的生物学活性作为牲畜饲料中的有益补充剂。它们与已知发生在种子作物麸皮中的半纤维素相连。在对玉米麸纤维预处理过程中，将连接水解为将其转换为乙醇，而HCA溶解在预处理溶液中。作为游离酸，他们恢复了特征，其中包括抗菌，抗炎和抗氧化特性。该项目将提供大量的HCA，用于与幼猪的喂养试验中，其中将与当前在欧洲使用的天然来源饲料补充剂以及未补充的饲料进行比较。将确定提取物的成分并进行全面的生化分析，包括研究胃肠道生理和肠道通透性。研究还将对肠道微生物组进行研究，以及所涉及的过程如何受到HCA作为主要饲料补充剂的替代的影响。这些研究的成功完成将为对HCA用作其他牲畜饮食中的补充而更全面的研究提供基础。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的评估来审查标准的评估值得支持的。