STTR Phase I: A Pair of Linked Cartographic Maps of our Brain Derived from Clinical Glaucoma Data

STTR 第一阶段：根据临床青光眼数据得出的一对大脑链接制图

• 批准号: 2025322
• 负责人: Gautam Thor
• 金额: $ 25.6万
• 依托单位: Retinal Registry
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-15 至 2022-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2025322&HistoricalAwards=false
• 关键词: STTR; Phase; Pair; Linked; Cartographic

The broader impact commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to improve the accessibility of eye health care. Glaucoma is a major cause of irreversible blindness but can be addressed with early detection, and the prevalence increases with age. However, existing tests can be tiring and difficult and require specialized equipment. This project will advance an inexpensive test for early detection for treatment. This low-cost, tablet-based tool can offer universal, cost-effective glaucoma screening.This Small Business Technology Transfer (STTR) Phase I project advances novel retinal testing for glaucoma detection through improved modeling and data analysis of the visual system. This project analyzes visual field test results to reveal a pair of linked cartographic maps that transmit central and peripheral retinal information to the brain through grouped retinal nerve fiber bundles segregated in a conformal mapping. A cone of photons displays the visual field information on the central S2 spherical non-Euclidean Riemann surface centered around the foveal axis, which lacks representation in the brain and can be considered as a singularity or reference region for each eye. Information on the S2 surface is transmitted through bundles of retinal nerve fibers that are grouped to represent single surfaces, and modeled as though the eye is a S3 4-dimensional hypersphere, with the blind spot being a singularity region and serving as the reference point. The retinal nerve fiber bundles transmitting the information to the brain are passively reordered at the blind spot and bring about an inversion of the Y (Up-Down) axis. Information from both eyes enables parallax removal and leads to depth perception. Information from the peripheral retinal regions of each eye is crossed across the optic chiasma and provides spatial locations of objects during peripheral vision.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业技术转让（STTR）第一阶段项目的更广泛的影响商业潜力是提高眼睛保健的可及性。 青光眼是不可逆失明的主要原因，但可以通过早期发现来解决，并且患病率随着年龄的增长而增加。然而，现有的测试可能是累人和困难的，需要专门的设备。该项目将推进一种廉价的早期检测治疗方法。 这一低成本、基于平板电脑的工具可以提供通用、经济高效的青光眼筛查。这一小企业技术转让（STTR）I期项目通过改进视觉系统的建模和数据分析，推进了青光眼检测的新型视网膜测试。 该项目分析视野测试结果，以揭示一对连接的地图，通过在保形映射中分离的成组视网膜神经纤维束将中央和周边视网膜信息传输到大脑。光子锥在以中央凹轴为中心的中心S2球面非欧几里德黎曼表面上显示视野信息，其在大脑中缺乏表示，并且可以被认为是每只眼睛的奇点或参考区域。S2表面上的信息通过视网膜神经纤维束传输，这些神经纤维束被分组以表示单个表面，并且将眼睛建模为S3四维超球体，其中盲点是奇异区域并用作参考点。将信息传输到大脑的视网膜神经纤维束在盲点处被动地重新排序，并导致Y轴（上下）反转。来自双眼的信息可以消除视差并产生深度感知。来自每只眼睛周边视网膜区域的信息通过视交叉，并在周边视觉期间提供物体的空间位置。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。