ISS: Engineering Multiple-Compartment Cartilage Tissue Construct for Space and Terrestrial Applications

ISS:为太空和陆地应用设计多室软骨组织结构

基本信息

  • 批准号:
    2025362
  • 负责人:
  • 金额:
    $ 40万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

The human musculoskeletal system is sensitive to biomechanical cues. Mechanical stimulation is important to cartilage health. An absence of biomechanical loading causes articular cartilage to decay. Our natural cartilage has limited ability to repair itself. Therefore, it is a significant challenge to regenerate authentic cartilage tissue after it degenerates. On Earth, prolonged joint immobilization can cause cartilage degradation. In microgravity, the similar absence of biomechanical loading caused likely also damages cartilage tissue and cells. In this work, we will develop an engineered cartilage tissue construct to overcome the presumed degradation of cartilage in microgravity. This work will benefit life on Earth by improving our understanding of the effects of microgravity on cartilage. The results of this work may lead to new therapies to treat cartilage injuries. The results of this work will also benefit astronauts’ health when they return to Earth. Furthermore, outcomes of this study will be used to introduce undergraduate and graduate engineering students to tissue engineering and nanomedicine. In addition, this work will increase diversity among biomedical engineers by encouraging underrepresented students to engage in science and engineering. Additional outreach activities are planned for middle/high school students and the general public. Mechanical stimulation is critical to maintain chondrogenesis (differentiation into cartilage) and cartilage homeostasis (health maintenance); an absence of biomechanical loading results in degradation of articular cartilage. Because natural cartilage has limited self-repair ability, it is a significant challenge to regenerate authentic cartilage tissue after it degenerates. On Earth, prolonged joint immobilization can cause catabolic (breakdown) activities of chondrocyte and subsequent cartilage degradation. In space, the absence of biomechanical loading caused by microgravity most likely also damages chondrocyte function and cartilage homeostasis. If we can engineer a cartilage tissue construct to overcome the presumed degradation of cartilage in microgravity, it should also improve tissue engineering research and healthcare on Earth. This work will create a construct which can automatically supply itself with mechano-responsive microRNA as a therapy to restore cartilage cell chondrogenesis. The result will be a long-lasting (homeostatic) cartilage tissue construct to maintain cartilage cell chondrogenesis and homeostasis in the long term.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
人体肌肉骨骼系统对生物力学信号非常敏感。机械刺激对软骨健康很重要。缺乏生物力学负荷会导致关节软骨衰退。我们的天然软骨修复自身的能力有限。 因此,在软骨组织退化后再生真正的软骨组织是一个重大的挑战。在地球上,长时间的关节固定会导致软骨退化。在微重力下,类似的生物力学载荷的缺乏可能也会损害软骨组织和细胞。在这项工作中,我们将开发一种工程化的软骨组织结构,以克服假定的软骨在微重力下的降解。这项工作将通过提高我们对微重力对软骨影响的理解来造福地球上的生命。 这项工作的结果可能导致治疗软骨损伤的新疗法。 这项工作的成果也将有利于宇航员返回地球时的健康。此外,本研究的结果将用于介绍本科生和研究生工程学生组织工程和纳米医学。此外,这项工作将通过鼓励代表性不足的学生从事科学和工程来增加生物医学工程师的多样性。 还计划为初中/高中学生和公众开展更多的外联活动。机械刺激对于维持软骨形成(分化为软骨)和软骨稳态(健康维持)至关重要;缺乏生物力学负荷会导致关节软骨退化。由于天然软骨具有有限的自我修复能力,因此在其退化后再生真实的软骨组织是一个重大挑战。在地球上,长时间的关节固定会导致软骨细胞的分解(分解)活动和随后的软骨退化。在太空中,微重力引起的生物力学负荷的缺乏很可能也会损害软骨细胞功能和软骨稳态。如果我们能够设计一种软骨组织结构来克服微重力下软骨的假定退化,它也应该改善地球上的组织工程研究和医疗保健。这项工作将创建一种结构,它可以自动为自己提供机械响应microRNA作为恢复软骨细胞软骨形成的疗法。其结果将是一个持久的(稳态)软骨组织结构,以保持软骨细胞软骨形成和稳态在长期。这一奖项反映了NSF的法定使命,并已被认为是值得通过评估使用基金会的智力价值和更广泛的影响审查标准的支持。

项目成果

期刊论文数量(14)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A structural and functional comparison between two recombinant human lubricin proteins: Recombinant human proteoglycan-4 (rhPRG4) vs ECF843
两种重组人润滑素蛋白之间的结构和功能比较:重组人蛋白聚糖 4 (rhPRG4) 与 ECF843
  • DOI:
    10.1016/j.exer.2023.109643
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Menon, Nikhil G.;Tanguay, Adam P.;Zhou, Libo;Zhang, Ling X.;Bobst, Cedric E.;Han, Mingyu;Ghosh, Mallika;Greene, George W.;Deymier, Alix;Sullivan, Benjamin D.
  • 通讯作者:
    Sullivan, Benjamin D.
Development of Engineered Cartilage Tissue Construct Maintaining Healthy Function of Cartilage Cell
开发维持软骨细胞健康功能的工程软骨组织结构
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Anne Yau, Ian Sands
  • 通讯作者:
    Anne Yau, Ian Sands
A Library of Janus Base Nano-Matrices for Tissue Engineering
用于组织工程的 Janus 基础纳米基质库
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Anne Yau, Libo Zhou
  • 通讯作者:
    Anne Yau, Libo Zhou
Nanomedicine strategies for central nervous system (CNS) diseases
  • DOI:
    10.3389/fbiom.2023.1215384
  • 发表时间:
    2023-08
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Shreya Nagri;Olivia Rice;Yupeng Chen
  • 通讯作者:
    Shreya Nagri;Olivia Rice;Yupeng Chen
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Yupeng Chen其他文献

Modeling Multimodal Consumer Heterogeneity in Conjoint Analysis – A Sparse Learning Approach
在联合分析中对多模式消费者异质性进行建模——一种稀疏学习方法
  • DOI:
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yupeng Chen;R. Iyengar;G. Iyengar
  • 通讯作者:
    G. Iyengar
Three-phase interface-assisted advanced electrochemistry-related applications
  • DOI:
    10.1016/j.xcrp.2021.100602
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    8.9
  • 作者:
    Yupeng Chen;Dexin Su;Yanxia Chen;Zhongpeng Zhu;Weifeng Li
  • 通讯作者:
    Weifeng Li
Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease.
抑制去泛素酶 USP28 可减弱常染色体显性多囊肾病中的囊肿生长。
  • DOI:
    10.1016/j.bcp.2022.115355
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    5.8
  • 作者:
    Ying Ren;Xiaodan Zhu;Kequan Fu;Haoran Zhang;Wenchao Zhao;Yang Lin;Qian Fang;Junqi Wang;Yupeng Chen;Dong Guo
  • 通讯作者:
    Dong Guo
Self-assembled , Nanometer-rough Cartilage Sealants for Orthopaedic Applications
用于骨科应用的自组装纳米粗糙软骨密封剂
  • DOI:
  • 发表时间:
    2008
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yupeng Chen;R. Pareta;H. Fenniri;T. Webster
  • 通讯作者:
    T. Webster
Angiopoietins/Tie-2 expression and angiogenesis in stomach carcinoma
胃癌中血管生成素/Tie-2 的表达和血管生成
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Zhenzhen Zhang;S. Zhang;Jian;P. Huang;Yupeng Chen
  • 通讯作者:
    Yupeng Chen

Yupeng Chen的其他文献

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{{ truncateString('Yupeng Chen', 18)}}的其他基金

PFI-TT: Platform Technology for Bioengineering Applications of Large mRNA
PFI-TT:大mRNA生物工程应用的平台技术
  • 批准号:
    2234570
  • 财政年份:
    2023
  • 资助金额:
    $ 40万
  • 项目类别:
    Standard Grant
CAREER: Assembly of Nanopieces for Controlled Penetration and Binding of Difficult-to-Reach Cartilage Matrix for siRNA Therapy against Osteoarthritis
职业:组装纳米片,用于控制穿透和结合难以到达的软骨基质,用于骨关节炎的 siRNA 治疗
  • 批准号:
    1905785
  • 财政年份:
    2018
  • 资助金额:
    $ 40万
  • 项目类别:
    Standard Grant
CAREER: Assembly of Nanopieces for Controlled Penetration and Binding of Difficult-to-Reach Cartilage Matrix for siRNA Therapy against Osteoarthritis
职业:组装纳米片,用于控制穿透和结合难以到达的软骨基质,用于骨关节炎的 siRNA 治疗
  • 批准号:
    1653702
  • 财政年份:
    2017
  • 资助金额:
    $ 40万
  • 项目类别:
    Standard Grant

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    2023
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Supporting Multiple Pathways Through the Undergraduate Engineering Curriculum
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