Neural correlates of reactive aggression and their relation to socio-emotional responsivity

反应性攻击的神经相关性及其与社会情绪反应的关系

• 批准号: 243340060
• 负责人: Professorin Dr. Ulrike M. Krämer
• 金额: --
• 依托单位: Klinik für Neurologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/243340060?language=en
• 关键词: Neural; correlates; reactive; aggression; their

Aggressive behavior is a basic form of social interactions in animals as well as in humans. Previousneuroscientific research on aggression has focused on pathological aggression in neurological and psychiatric patients. Studies have demonstrated altered responsivity to socio-emotional stimuli in these patients that is related to dysfunctions of amygdala and orbitofrontal cortex (OFC). First neuroscientific studies in healthy humans support the relevance of OFC, but show also a role of other regions such as the cingulate gyrus and the striatum. To examine neural correlates of reactive aggression in humans, we will take advantage of a well-established paradigm from social psychology, the Taylor Aggression Paradigm. Based on previous work of our own lab and other groups, we want to identify relevant brain regions involved in aggressive social interactions and clarify their role with respect to responsivity to socio-emotional cues. We will examine both the effect of experimental manipulations of the socio-emotional context as well as the interindividual variability in the socio-emotional responsivity.

攻击性行为是动物和人类社会交往的一种基本形式。以往对攻击性的神经科学研究主要集中在神经科和精神科患者的病理性攻击性。研究表明，这些患者对社会情绪刺激的反应性改变与杏仁核和眶前皮质(OFC)功能障碍有关。首次对健康人进行的神经科学研究支持OFC的相关性，但也显示了扣带回和纹状体等其他区域的作用。为了检验人类反应性攻击的神经相关性，我们将利用社会心理学中一个成熟的范式--泰勒攻击范式。基于我们自己的实验室和其他研究小组之前的工作，我们希望确定参与攻击性社会互动的相关大脑区域，并澄清它们在对社会情绪线索的响应性方面所起的作用。我们将考察社会情绪背景的实验性操纵的效果以及社会情绪响应性的个体间差异。