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Neural Correlates and Modifiers of Cognitive Aging

Neural Correlates and Modifiers of Cognitive Aging
认知衰老的神经相关因素和调节因素
批准号：
7780749
负责人：
NAFTALI RAZ
金额：
$60.8万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
项目状态：
已结题
起止时间：
1993-09-30 至 2015-05-31
来源：
https://reporter.nih.gov/project-details/7780749
关键词：
AccelerationAcetylcholineAcuteAdultAdverse effectsAffectAgeAgingAging-Related ProcessAllelesAlzheimer&aposs DiseaseAmericanAnti-Inflammatory AgentsAnti-inflammatoryApoptosisAttentionAwardBiochemicalBiologicalBiological AssayBiological MarkersBiological ProcessBloodBlood GlucoseBlood PressureBlood TestsBlood VesselsBlood specimenBoxingBrainBrain regionBrain-Derived Neurotrophic FactorC-reactive proteinCalciumCardiacCatalytic DomainCell ProliferationCerebrumChromosomes, Human, Pair 2ChronicClinicalCognitionCognitiveCognitive agingCohort EffectCollectionCompensatory HyperinsulinemiaComplementComputer softwareCross-Sectional StudiesDataData AnalysesData CollectionData SetDecelerationDesire for foodDeteriorationDiabetes MellitusDiffusionDiseaseDopamineElderlyEnsureEnzymesEpisodic memoryEvaluationExhibitsExperimental Diabetes MellitusFamilyFastingFollow-Up StudiesGenesGeneticGenetic EpistasisGenetic PolymorphismGenetic RiskGenetic VariationGenomicsGenotypeGlucokinaseGlucoseGlucose-6-PhosphateGlycosylated HemoglobinGoalsGrowthHTR2A geneHealthHippocampus (Brain)HomocysteineHomocystineHomozygoteHospitalsHumanHyperglycemiaHypertensionImageImage AnalysisIndividualIndividual DifferencesInflammationInflammatoryInflammatory ResponseInstructionInsula of ReilInsulinInsulin ResistanceInterleukin-13Interleukin-6InvestigationIronKAI1 geneKnockout MiceLengthLesionLettersLightLinkLiteratureLiverLocationLongitudinal StudiesMTHFR geneMagnetic Resonance ImagingMaintenanceManualsMeasurementMeasuresMemoryMetabolicMethodologyMethodsMissionModelingModificationMorbidity - disease rateMuscarinic Acetylcholine ReceptorMyelinNatureNeocortexNeurobiologyNeurotransmittersNicotinic ReceptorsOther GeneticsPancreasParticipantPatternPerformancePersonal SatisfactionPersonsPhasePhosphorylationPhysiologic pulsePhysiologicalPlayPopulationPredispositionPricePrincipal InvestigatorProcessProgress ReportsPropertyProteinsProxyPublishingPulse PressureRecruitment ActivityRelative (related person)RelianceReportingResearchResearch PersonnelResourcesRiskRisk FactorsRoleSamplingSampling StudiesSerotoninSerotonin Receptor 5-HT2AShapesShort-Term MemorySiteSolutionsSpeedStimulusStructureSurfaceSystemTestingTimeTrainingUniversitiesVariantVascular DementiaVentricularVertebral columnWorkWritingage effectage relatedaging brainarea striatabaseblood glucose regulationblood pressure regulationbrain shapebrain volumecardiovascular risk factorcaudate nucleuscholinergiccognitive changecohortcytokinedesigndiabetes riskexecutive functionfasting glucosefollow-upgenetic risk factorgenetic variantglucose metabolismglucose sensorglucose uptakeglucose-6-phosphataseglycemic controlhealthy aginghuman TCF7L2 proteinimprovedindexinginsightinstrumentinsulin sensitivityinterestiron metabolismlongitudinal analysismeetingsmembermetabolic abnormality assessmentneocorticalneuroimagingnormal agingpresynapticprocessing speedprogramsrelating to nervous systemresearch studyresponsesexskillssynaptogenesistrendway findingwhite matter

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