SBIR Phase I: RAPID Integrated and automated genomics platform for hospitals responding to COVID-19

SBIR 第一阶段：用于医院应对 COVID-19 的 RAPID 集成自动化基因组学平台

• 批准号: 2027424
• 负责人: Susanna Lamers
• 金额: $ 25.6万
• 依托单位: Bioinfoexperts, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2027424&HistoricalAwards=false
• 关键词: SBIR; Phase; RAPID; Integrated; automated

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will be a user-friendly and scalable infection control surveillance software platform using advanced biotech and data analytics for monitoring the COVID-19 pandemic. The COVID-19 pandemic highlights the need for rapid testing, analysis, and tracking. The innovation provides access to next-generation sequence technologies to healthcare facilities, as well as a centralized system to integrate and share hospital-level data with microbial information to be shared on any geographic scale. The platform automates the analysis of bacterial and viral data, delivering simplified and clinically relevant results via interactive web interfaces. The proposed technology offers important data to clinicians and other experts. The intellectual merit of this SBIR Phase I project is to generate the largest collection of SARS-CoV-2 whole genomes with matched respiratory microbiomes for clinicians to rapidly test medical hypotheses for diagnostic and prescriptive use. Our project has three major objectives: 1) incorporate an automated analytical pipeline to process whole genomes of infecting strains of SARS-CoV-2; 2) integrate viral genomes with patient microbiomes and clinical records, and; 3) deliver clear, easy-to-interpret results via an interactive web interface. The infection control cloud-based software platform solution enables “precision epidemiology” integrating pathogen genomics with clinical and patient demographics to improve patient outcomes and enhance the capability of the health system for infection control and surveillance.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

此小型企业创新研究（SBIR）第一阶段项目的更广泛影响/商业潜力将是一个用户友好且可扩展的感染控制监测软件平台，使用先进的生物技术和数据分析来监测COVID-19大流行。COVID-19疫情凸显了快速检测、分析和跟踪的必要性。这项创新为医疗机构提供了下一代测序技术，以及一个集中式系统，用于整合和共享医院级数据，并在任何地理范围内共享微生物信息。该平台可自动分析细菌和病毒数据，通过交互式Web界面提供简化的临床相关结果。这项技术为临床医生和其他专家提供了重要的数据。该SBIR第一阶段项目的智力价值是产生最大的SARS-CoV-2全基因组集合，并为临床医生提供匹配的呼吸道微生物组，以快速测试诊断和处方使用的医学假设。我们的项目有三个主要目标：1）整合自动化分析管道来处理SARS-CoV-2感染菌株的全基因组; 2）将病毒基因组与患者微生物组和临床记录整合在一起; 3）通过交互式网络界面提供清晰，易于解释的结果。基于云的感染控制软件平台解决方案能够实现“精确流行病学”，将病原体基因组学与临床和患者人口统计学相结合，以改善患者治疗效果，并增强卫生系统的感染控制和监测能力。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。