SBIR Phase I: HaloFilm as a virucide against COVID-19 infection

小型企业创新研究(SBIR)第一阶段项目的更广泛影响是开发具有独特应用和功效特征的抗病毒表面涂层。有证据表明，新冠肺炎病毒株可以在不锈钢和塑料上存活长达三天，这在交通繁忙的环境中是一个潜在的有害情况，如地铁旋转门、公交车和医院里高接触的表面。此外，即使在医院，清洁和消毒也可能不够全面，表面很容易被重新污染，直到重新使用消毒剂。这项拟议的技术使氯基消毒剂的有效期长达4周。该涂层使氯处于物理和化学状态，对病毒具有活性，但仍然安全，接触时不会引起皮肤刺激。这种涂层可以将任何表面变成抗微生物和抗病毒的表面。拟议的SBIR第一阶段项目将评估一种可充电和可重复使用的喷涂表面涂层的实用性、有效性和安全性，以便它可以用作抗微生物表面涂层，特别是防止冠状病毒的传播。最先进的是定期使用液体喷雾消毒剂来杀灭表面上的病毒。然而，典型的活性成分，如氯、季铵化合物、酒精、过氧乙酸或过氧化氢，对病毒起作用的时间只有几分钟，当然不到一小时，留下的表面可能会被重新污染。该提案的技术目标集中在1)评估涂层在应用后的特定时间的杀毒活性；2)确定涂层上冠状病毒的半衰期，以便与其他材料进行比较。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact of this Small Business Innovation Research (SBIR) Phase I project is to develop an antiviral surface coating with unique application and efficacy features. Evidence suggests that the COVID-19 virus strain can remain live on stainless steel and plastic for as long as three days, a potentially harmful situation in environments with high traffic, such as subway turnstiles, buses, and high-touch surfaces in hospitals. Furthermore, even in hospitals, cleaning and disinfecting can be insufficiently comprehensive than desired, with surfaces that may easily be recontaminated until disinfectants are reapplied. The proposed technology enables chlorine-based disinfectants to be effective for as long as 4 weeks. The coating keeps chlorine in a physical and chemical state that is active against viruses, but remains safe and does not cause skin irritation upon contact. The coating can turn any surface into an antimicrobial, and antiviral, surface. The proposed SBIR Phase I project will assess the utility, efficacy and safety of a spray-on surface coating that is rechargeable and can be reapplied, such that it can be used as an antimicrobial surface coating, particularly to prevent transmission of coronaviruses. The state-of-the-art is to regularly use liquid spray disinfectants to kill viruses on surfaces. However, typical active ingredients, such as chlorine, quaternary ammonium compounds, alcohol, peracetic acid or hydrogen peroxide, are active against viruses for a matter of minutes and certainly less than an hour, leaving a surface that can potentially be recontaminated. The technical aims of the proposal focus on 1) assessing the virucidal activities of the coating at specific times after application; 2) determining the half-life of coronaviruses on the coating for comparison to other materials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.