Bioengineering in Microgravity Workshop; International Space Station US National Laboratory Virtual Symposium

微重力生物工程研讨会；

• 批准号: 2028635
• 负责人: Marcello Giulianotti
• 金额: $ 3万
• 依托单位: Center for the Advancement of Science in Space, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-15 至 2021-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2028635&HistoricalAwards=false
• 关键词: Bioengineering; Microgravity; Workshop; International; Space

This award will support research that will contribute new knowledge related to bioengineering in Space. The International Space Station US National Laboratory will host a Virtual Symposium to strategically partner with approximately 50 diverse scientists, engineers, and clinicians. This collaboration will leverage their translational expertise to accelerate the understanding of fundamental science that could lead to biomedical breakthroughs by studying biological phenomena in Low Earth Orbit. The goals of the Symposium are: 1) to leverage translational expertise from scientists, engineers, and clinicians to accelerate our understanding of how biomedical breakthroughs can be developed or tested in space (low earth orbit); 2) produce a written document detailing the results of the discussions. Specifically, this document will identify research areas and findings to propel thought leadership of the low earth orbit environment, and how this work could ultimately lead to clinical translation. This is work for the betterment of humankind and could have significant benefits to the US economy. The ability to perform research in a microgravity environment provides unprecedented opportunities for fundamental research. Under the umbrella of Regenerative Medicine, four focus areas for the Symposium have been identified: Stem cells; Biofabrication and 3D bioprinting; Organoids/microphysiological systems; Artificial intelligence (AI) and Robotics. Removing the effects of gravity has contributed significantly to the collective fundamental knowledge of cellular behavior, cell-cell interactions, tissue development and regeneration, as well as the aggregate interactions in the context of a whole organism. Pioneering bioengineering experiments on the International Space Station coupled with ground-based studies have demonstrated that microgravity enables the study of novel features not attainable under unit gravity conditions. These include changes to stem cell proliferation rates and differentiation. Printing biological tissues in microgravity also promises advantages in the use of lower-viscosity biomaterials or bioinks and the ability to fabricate diaphanous, intricate structures. These processes are heavily reliant on biomechanical and mechanobiological cues that are affected by the gravitational field. In this way, the International Space Station provides an unprecedented opportunity to advance fundamental research in biomechanics and mechanobiology. The participants of this interdisciplinary workshop will be tasked with determining and then publicly disseminating the roadmap for future advances in microgravity bioengineering. The results will be critical for funders that currently sponsor bioengineering research which relies on reduced microgravity environments. The results will enable these agencies and the researchers they support to appropriately plan for future programs and studies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项将支持将贡献与太空生物工程相关的新知识的研究。国际空间站美国国家实验室将举办虚拟研讨会，与大约50名不同的科学家，工程师和临床医生进行战略合作。这项合作将利用他们的翻译专业知识，通过研究低地球轨道上的生物现象，加速对基础科学的理解，从而实现生物医学的突破。研讨会的目标是：1）利用科学家，工程师和临床医生的翻译专业知识，加速我们对如何在太空（低地球轨道）开发或测试生物医学突破的理解; 2）编写一份详细说明讨论结果的书面文件。 具体来说，本文件将确定研究领域和发现，以推动低地球轨道环境的思想领导，以及这项工作如何最终导致临床翻译。这是为改善人类而做的工作，可能会对美国经济产生重大利益。在微重力环境中进行研究的能力为基础研究提供了前所未有的机会。在再生医学的保护伞下，研讨会的四个重点领域已经确定：干细胞;生物制造和3D生物打印;类器官/微生理系统;人工智能（AI）和机器人。 消除重力的影响对细胞行为、细胞间相互作用、组织发育和再生以及整个生物体背景下的聚集体相互作用的集体基础知识做出了重大贡献。国际空间站上的开创性生物工程实验以及地面研究表明，微重力可以研究单位重力条件下无法实现的新特征。这些包括干细胞增殖率和分化的变化。在微重力下打印生物组织还有望在使用低粘度生物材料或生物墨水以及制造透明、复杂结构的能力方面带来优势。这些过程在很大程度上依赖于生物力学和机械生物学线索，这些线索受到重力场的影响。通过这种方式，国际空间站为推进生物力学和机械生物学的基础研究提供了前所未有的机会。这次跨学科研讨会的参与者将负责确定并公开传播微重力生物工程未来进展的路线图。这些结果对于目前赞助依赖于降低微重力环境的生物工程研究的资助者来说至关重要。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Biomanufacturing in low Earth orbit for regenerative medicine.

• DOI: 10.1016/j.stemcr.2021.12.001
• 发表时间: 2022-01-11
• 期刊: Stem cell reports
• 影响因子: 5.9
• 作者: Sharma A;Clemens RA;Garcia O;Taylor DL;Wagner NL;Shepard KA;Gupta A;Malany S;Grodzinsky AJ;Kearns-Jonker M;Mair DB;Kim DH;Roberts MS;Loring JF;Hu J;Warren LE;Eenmaa S;Bozada J;Paljug E;Roth M;Taylor DP;Rodrigue G;Cantini P;Smith AW;Giulianotti MA;Wagner WR
• 通讯作者: Wagner WR