Collaborative Research: RAPID: Integrative Modeling of Intervention Serology and the Role of Shield Immunity in Reducing COVID-19 Epidemic Spread
合作研究:RAPID:干预血清学的综合建模以及屏蔽免疫在减少 COVID-19 流行病传播中的作用
基本信息
- 批准号:2032084
- 负责人:
- 金额:$ 10万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-01 至 2021-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Developing intervention strategies that can reduce transmission and alleviate the impacts of social distancing is an essential goal of near- and long-term public health responses to the ongoing COVID-19 pandemic. This project combines epidemic models of COVID-19 with serological testing modules to develop actionable policies to robustly identify recovered individuals who have protective antibodies to SARS-CoV-2019 as a means to (i) reduce infection transmission; (ii) facilitate interaction substitution that can reduce transmission risk (the basis for ‘shield immunity’); (iii) enable safer return to normal economic activity. Findings from shield immunity modeling studies will be released via open-source software, disseminated via policy-making documents that guide the design, interpretation, and action-taking from serological testing initiatives, and communicated with local, state, and national decision makers (e.g. CDC) via rapid response reports. The project will help assess feasibility of scaling up targeted serological testing and shield immunity-based interventions for the public good and economic re-engagement. Additionally, this project will provide training opportunities for graduate students and a postdoctoral scholar.Mitigation and suppression have emerged as the primary means to control and contain local spread of COVID-19. Public health interventions including lockdowns and shelter-in-place orders both reduce infections and raise questions of sustainability and long-term tactics, given the drastic consequences for socio-economic health and well-being. This project expands intervention approaches by extending the conceptual and practical foundations for ‘shield immunity’, i.e., the identification and deployment of recovered individuals as focal points for sustaining safer interactions via interaction substitution of otherwise risky contacts between individuals of unknown disease status. This project evaluates the practical potential of shield immunity by combining realistic scale-out of test capacity and reliability into an integrated framework with explicit consideration of individual status both with respect to disease status and with respect to serological test status. Altogether, the research integrates epidemiological dynamics, nonlinear dynamics, and statistical test analytics. The analysis of combined effects of interaction substitution, test scale, and test reliability will help inform efforts to prudently leverage information on seroconversion and immunity to help control COVID-19 spread while facilitating the safer return of individuals back to economic and social activities. This RAPID award is made by the Ecology and Evolution of Infectious Disease Program in the Division of Environmental Biology, using funds from the Coronavirus Aid, Relief, and Economic Security (CARES) Act.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
制定可减少传播和减轻社交距离影响的干预策略,是应对持续COVID-19大流行的近期和长期公共卫生应对措施的重要目标。该项目将COVID-19的流行模型与血清学检测模块相结合,以制定可操作的政策,以强有力地识别具有SARS-CoV-2019保护性抗体的康复者,以此作为(i)减少感染传播的手段;(ii)促进相互作用替代,从而降低传播风险(“盾牌免疫”的基础);(iii)使更安全地恢复正常的经济活动。 盾免疫建模研究的结果将通过开源软件发布,通过指导血清学检测计划的设计、解释和行动的政策制定文件传播,并通过快速反应报告与地方、州和国家决策者(如CDC)沟通。该项目将帮助评估扩大有针对性的血清学检测的可行性,并保护基于免疫的干预措施,以促进公共利益和经济重新参与。此外,该项目还将为研究生和博士后学者提供培训机会。缓解和抑制已成为控制和遏制COVID-19在当地传播的主要手段。公共卫生干预措施,包括封锁和就地避难令,既减少了感染,又提出了可持续性和长期策略的问题,因为这对社会经济健康和福祉造成了严重后果。 该项目通过扩展“盾牌免疫”的概念和实践基础,即,确定和部署康复者作为联络点,通过相互作用替代疾病状况不明者之间的其他危险接触,维持更安全的相互作用。 该项目通过将测试能力和可靠性的实际扩展结合到一个综合框架中,明确考虑到疾病状态和血清学测试状态的个人状态,评估屏蔽免疫的实际潜力。 总而言之,该研究整合了流行病学动力学、非线性动力学和统计测试分析。 对相互作用替代、测试规模和测试可靠性的综合影响的分析将有助于为谨慎利用血清转化和免疫信息的努力提供信息,以帮助控制COVID-19传播,同时促进个人更安全地重返经济和社会活动。该奖项由环境生物学部门的传染病生态学和进化计划颁发,使用冠状病毒援助,救济和经济安全(CARES)法案的资金。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A framework for monitoring population immunity to SARS-CoV-2.
- DOI:10.1016/j.annepidem.2021.08.013
- 发表时间:2021-11
- 期刊:
- 影响因子:5.6
- 作者:Lopman BA;Shioda K;Nguyen Q;Beckett SJ;Siegler AJ;Sullivan PS;Weitz JS
- 通讯作者:Weitz JS
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Benjamin Lopman其他文献
Comparative Effectiveness of Alternative Intervals between First and Second Doses of the mRNA COVID-19 Vaccines: a Trial Emulation Approach
mRNA COVID-19 疫苗第一剂和第二剂之间替代间隔的有效性比较:试验模拟方法
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Kayoko Shioda;A. Breskin;Pravara M. Harati;Allison T Chamberlain;Benjamin Lopman;E. T. R. McQuade - 通讯作者:
E. T. R. McQuade
Comparative effectiveness of alternative intervals between first and second doses of the mRNA COVID-19 vaccines
第一剂和第二剂 mRNA COVID-19 疫苗之间替代间隔的有效性比较
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:16.6
- 作者:
Kayoko Shioda;A. Breskin;Pravara M. Harati;Allison T Chamberlain;Toshiaki Komura;Benjamin Lopman;Elizabeth T Rogawski McQuade - 通讯作者:
Elizabeth T Rogawski McQuade
Benjamin Lopman的其他文献
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