SBIR Phase I: Antiviral Activity of Novel Nitrogen-Doped, Carbon Supported Catalysts Against Covid-19 Surrogates

SBIR 第一阶段：新型氮掺杂碳支撑催化剂对 Covid-19 替代物的抗病毒活性

• 批准号: 2032653
• 负责人: Franchessa Sayler
• 金额: $ 25.6万
• 依托单位: ThruPore Technologies
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2032653&HistoricalAwards=false
• 关键词: SBIR; Phase; Antiviral; Activity; Novel

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project would be to slow the spread of viruses indoors, mitigating the need for social distancing. Microbes and viruses do not survive on specific surfaces. This project will explore if special nanoparticles can be used to kill viruses, such as that which causes COVID-19. This would help slow contagion and protect indoor spaces. This SBIR Phase I project proposes to determine if carbon supported nanoparticles can destructively deactivate SARS-CoV-2 under biologically realistic conditions. This project will explore novel nitrogen-doped carbon supports loaded with catalytic nanoparticles to destructively interact with SARS-CoV-2. Nitrogen in carbonaceous materials interacts with viruses and can increase performance in catalytic chemical reactions; however, to date this has not been leveraged at scale. In this project, three different types of nitrogen-doped carbon supports will be produced and compared against two state-of-practice carbon supports. Each support will have four different catalytic nanoparticles attached and then will be tested for efficacy. These catalysts will be compared on their ability to destroy coronavirus surrogates using an ASTM standardized test for evaluating medical mask efficiency. Once a suitable combination of catalyst support and catalytic nanoparticles is determined, the solution and process can be optimized.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小型企业创新研究(SBIR)项目的更广泛的影响/商业潜力将是减缓病毒在室内的传播，减少社交距离的需要。微生物和病毒不能在特定的表面上存活。该项目将探索是否可以使用特殊的纳米颗粒来杀死病毒，例如导致新冠肺炎的病毒。这将有助于减缓传染病的蔓延，保护室内空间。这个SBIR第一阶段项目建议确定碳支持的纳米颗粒在生物现实条件下是否能够破坏性地灭活SARS-CoV-2。该项目将探索新型氮掺杂碳载体，负载催化纳米颗粒，以破坏性地与SARS-CoV-2相互作用。碳材料中的氮与病毒相互作用，可以提高催化化学反应的性能；然而，到目前为止，这还没有被大规模利用。在这个项目中，将生产三种不同类型的掺氮碳载体，并与两种实际应用的碳载体进行比较。每个载体将附着四个不同的催化纳米颗粒，然后将进行有效性测试。这些催化剂将使用ASTM评估医用口罩效率的标准化测试来比较它们销毁冠状病毒替代品的能力。一旦确定了催化剂载体和催化纳米颗粒的合适组合，就可以优化解决方案和工艺。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。