SBIR Phase I: Antiviral Activity of Novel Nitrogen-Doped, Carbon Supported Catalysts Against Covid-19 Surrogates

该小企业创新研究 (SBIR) 项目更广泛的影响/商业潜力将是减缓病毒在室内的传播，从而减轻社交距离的需要。 微生物和病毒无法在特定表面上生存。该项目将探索是否可以使用特殊的纳米粒子来杀死病毒，例如导致 COVID-19 的病毒。 这将有助于减缓传染并保护室内空间。 该 SBIR 第一阶段项目旨在确定碳支撑的纳米颗粒是否可以在生物学真实条件下破坏性地灭活 SARS-CoV-2。该项目将探索载有催化纳米颗粒的新型氮掺杂碳载体，以与 SARS-CoV-2 发生破坏性相互作用。碳质材料中的氮与病毒相互作用，可以提高催化化学反应的性能；然而，迄今为止，这一点尚未得到大规模利用。在该项目中，将生产三种不同类型的氮掺杂碳载体，并与两种实际碳载体进行比较。每个支撑物将附着四种不同的催化纳米粒子，然后将测试其功效。将使用 ASTM 标准化测试来评估这些催化剂破坏冠状病毒替代物的能力，以评估医用口罩的效率。一旦确定了催化剂载体和催化纳米颗粒的合适组合，就可以优化解决方案和工艺。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project would be to slow the spread of viruses indoors, mitigating the need for social distancing. Microbes and viruses do not survive on specific surfaces. This project will explore if special nanoparticles can be used to kill viruses, such as that which causes COVID-19. This would help slow contagion and protect indoor spaces. This SBIR Phase I project proposes to determine if carbon supported nanoparticles can destructively deactivate SARS-CoV-2 under biologically realistic conditions. This project will explore novel nitrogen-doped carbon supports loaded with catalytic nanoparticles to destructively interact with SARS-CoV-2. Nitrogen in carbonaceous materials interacts with viruses and can increase performance in catalytic chemical reactions; however, to date this has not been leveraged at scale. In this project, three different types of nitrogen-doped carbon supports will be produced and compared against two state-of-practice carbon supports. Each support will have four different catalytic nanoparticles attached and then will be tested for efficacy. These catalysts will be compared on their ability to destroy coronavirus surrogates using an ASTM standardized test for evaluating medical mask efficiency. Once a suitable combination of catalyst support and catalytic nanoparticles is determined, the solution and process can be optimized.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.