I-Corps: Load bearing ceramic bone scaffolds produced via 3D printing

I-Corps：通过 3D 打印生产的承重陶瓷骨支架

• 批准号: 2035370
• 负责人: Eugene Olevsky
• 金额: $ 5万
• 依托单位: San Diego State University Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2035370&HistoricalAwards=false
• 关键词: Corps; Load; bearing; ceramic; bone

The broader impact/commercial potential of this I-Corps project is the development of a novel solution for bone repair and replacement scaffolds. In the United States alone, 5-10% of fracture repairs experience delayed healing or non-union, which means close to 800,000 patients suffer from reoperation or complications. 3D printing will make this method of creating bone scaffolds affordable and attainable. The proposed technology provides 3D printed, customizable, ceramic bone scaffolds that are biocompatible and mimic the mechanical properties of native bone. Using 3D printing as an affordable manufacturing process to make the novel scaffold will provide a way for bone repairs to be more accessible and successful.This I-Corps project is based on the development of a powder preparation technique that produces customizable bone scaffolds via a custom-made powder-based 3D printer. The proposed technology addresses major issues with current methods of repairing or replacing bone injuries. Novel features of the scaffolds produced using the proposed technology include injury-specific geometry, strength as high as native bone, biocompatible ceramic material, and highly tailorable properties.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个i-Corps项目的更广泛的影响/商业潜力是开发一种用于骨修复和替换支架的新解决方案。仅在美国，5%-10%的骨折修复经历了延迟愈合或骨不连，这意味着近80万患者遭受再次手术或并发症。3D打印将使这种构建骨支架的方法变得负担得起，而且可以实现。这项拟议的技术提供了3D打印的、可定制的陶瓷骨支架，这些支架具有生物兼容性，并模拟了天然骨的机械性能。使用3D打印作为一种负担得起的制造工艺来制造这种新型支架，将为骨骼修复提供一种更容易和更成功的方法。这个i-Corps项目基于一种粉末制备技术的开发，该技术通过定制的粉末3D打印机生产可定制的骨支架。这项拟议的技术解决了目前修复或替换骨骼损伤的主要方法存在的主要问题。使用建议的技术生产的支架的新颖特征包括特定于损伤的几何形状、高达天然骨骼的强度、生物兼容的陶瓷材料以及高度可剪裁的特性。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。