I-Corps: Quantitative Tissue Oxygen Sensors

I-Corps：定量组织氧传感器

• 批准号: 2035836
• 负责人: Roman Lubynsky
• 金额: $ 5万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2035836&HistoricalAwards=false
• 关键词: Corps; Quantitative; Tissue; Oxygen; Sensors

The broader impact/commercial potential of this I-Corps project is to personalize therapies and improve outcomes for patients with a wide range of diseases and ailments. Deviation from normal tissue oxygen levels can cause poor outcomes for patients, ranging from resistance to radiation therapy for cancer patients to amputation for a patient suffering from a crushed limb. Clinical interventions to address these and other diseases require an oxygen sensing method that produces actionable data and is in a format that is compatible with current clinical care. For example, when treating cancer, understanding the distribution and quantitative levels of tumor oxygen could enable physicians to apply higher doses of radiation to the low oxygen regions in order to combat the treatment resistance typically observed in these environments. This oxygen sensor is a platform technology that can be used in a wide range of clinical and pre-clinical applications. It overcomes the limitations of both past and current oxygen sensing alternatives and provides minimally invasive, quantitative, and absolute measurements of tissue oxygen. This I-Corps project focuses on advancing a novel oxygen sensing polymer that is measured non-invasively using magnetic resonance imaging (MRI). This material is used to quantify oxygen by measuring the influence of molecular oxygen on the MRI properties of the silicone. The MRI properties are a function of the concentration of oxygen that is in the sensor at any given time. The MRI measurements can be converted to oxygen values using a calibration curve to provide the actionable clinical information to physicians. The sensor is made completely of silicone which limits the ingress of water and biological materials that could compromise measurement quality. The elastomeric nature of the silicone sensor allows it to be customized for a wide range of clinical applications. The sensor offers quantitative and long-term tracking of tissue oxygen with a technique and device that is compatible with the clinical workflow. This sensor has been evaluated in multiple pre-clinical small animal models and is in an early feasibility clinical trial for cervical cancer.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目更广泛的影响/商业潜力是为患有多种疾病的患者提供个性化治疗并改善结果。偏离正常组织氧水平可能会导致患者预后不良，包括癌症患者对放射治疗的抵抗力以及肢体骨折患者的截肢。解决这些疾病和其他疾病的临床干预措施需要一种氧传感方法，该方法可以产生可操作的数据，并且格式与当前的临床护理兼容。例如，在治疗癌症时，了解肿瘤氧的分布和定量水平可以使医生能够对低氧区域施加更高剂量的辐射，以对抗通常在这些环境中观察到的治疗耐药性。该氧传感器是一种平台技术，可用于广泛的临床和临床前应用。它克服了过去和当前氧传感替代方案的局限性，并提供组织氧的微创、定量和绝对测量。该 I-Corps 项目的重点是开发一种新型氧传感聚合物，该聚合物可使用磁共振成像 (MRI) 进行非侵入性测量。该材料用于通过测量分子氧对有机硅 MRI 性能的影响来量化氧。 MRI 特性是任何给定时间传感器中氧气浓度的函数。 MRI 测量结果可以使用校准曲线转换为氧气值，为医生提供可操作的临床信息。该传感器完全由硅胶制成，可限制水和生物材料的进入，从而影响测量质量。硅胶传感器的弹性体性质使其能够针对广泛的临床应用进行定制。该传感器通过与临床工作流程兼容的技术和设备提供组织氧的定量和长期跟踪。该传感器已在多个临床前小动物模型中进行了评估，并且正在进行宫颈癌的早期可行性临床试验。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。