I-Corps: Quantitative Tissue Oxygen Sensors

I-Corps：定量组织氧传感器

• 批准号: 2035836
• 负责人: Roman Lubynsky
• 金额: $ 5万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2035836&HistoricalAwards=false
• 关键词: Corps; Quantitative; Tissue; Oxygen; Sensors

The broader impact/commercial potential of this I-Corps project is to personalize therapies and improve outcomes for patients with a wide range of diseases and ailments. Deviation from normal tissue oxygen levels can cause poor outcomes for patients, ranging from resistance to radiation therapy for cancer patients to amputation for a patient suffering from a crushed limb. Clinical interventions to address these and other diseases require an oxygen sensing method that produces actionable data and is in a format that is compatible with current clinical care. For example, when treating cancer, understanding the distribution and quantitative levels of tumor oxygen could enable physicians to apply higher doses of radiation to the low oxygen regions in order to combat the treatment resistance typically observed in these environments. This oxygen sensor is a platform technology that can be used in a wide range of clinical and pre-clinical applications. It overcomes the limitations of both past and current oxygen sensing alternatives and provides minimally invasive, quantitative, and absolute measurements of tissue oxygen. This I-Corps project focuses on advancing a novel oxygen sensing polymer that is measured non-invasively using magnetic resonance imaging (MRI). This material is used to quantify oxygen by measuring the influence of molecular oxygen on the MRI properties of the silicone. The MRI properties are a function of the concentration of oxygen that is in the sensor at any given time. The MRI measurements can be converted to oxygen values using a calibration curve to provide the actionable clinical information to physicians. The sensor is made completely of silicone which limits the ingress of water and biological materials that could compromise measurement quality. The elastomeric nature of the silicone sensor allows it to be customized for a wide range of clinical applications. The sensor offers quantitative and long-term tracking of tissue oxygen with a technique and device that is compatible with the clinical workflow. This sensor has been evaluated in multiple pre-clinical small animal models and is in an early feasibility clinical trial for cervical cancer.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力是个性化疗法并改善各种疾病和疾病的患者的预后。偏离正常组织氧气水平会导致患者的结局不佳，从抗药性到癌症患者的放射治疗到肢体压伤的患者的截肢。解决这些疾病和其他疾病的临床干预措施需要一种产生可行数据的氧气传感方法，并且具有与当前临床护理兼容的格式。例如，当治疗癌症时，了解肿瘤氧的分布和定量水平可以使医生能够将较高剂量的辐射施加到低氧气区域，以应对在这些环境中通常观察到的治疗耐药性。该氧气传感器是一种平台技术，可用于广泛的临床和临床前应用。它克服了过去和当前的氧气传感替代方案的局限性，并提供了组织氧的微创，定量和绝对测量。这个I-Corps项目的重点是推进一种新型的氧气传感聚合物，该聚合物是使用磁共振成像（MRI）非侵入性测量的。该材料用于通过测量分子氧对硅酮MRI特性的影响来量化氧。 MRI特性是任何给定时间中传感器中氧浓度的函数。 可以使用校准曲线将MRI测量值转换为氧气值，以向医生提供可操作的临床信息。该传感器完全由硅树脂制成，从而限制了可能损害测量质量的水和生物材料的入口。硅酮传感器的弹性性质允许对广泛的临床应用进行自定义。该传感器通过与临床工作流兼容的技术和设备对组织氧的定量和长期跟踪。该传感器已在多个临床前小动物模型中进行了评估，并且正在针对宫颈癌的早期可行性临床试验中进行评估。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子和更广泛影响的评估评估标准来通过评估来支持的。