SBIR Phase I: A Beat-to-Beat Blood Pressure Monitor Using Micro-Nanoscale Wrinkled Functional Materials

这个小型企业创新研究（SBIR）第一阶段项目的更广泛的影响/商业潜力旨在为医务工作者和消费者提供使用易于使用的粘合剂软传感器进行连续血压监测的实用性，这可以大大改善个性化护理和患者结果。当患者接受手术时，血压被监测，因为突然下降与不可逆的组织和/或器官损伤有关，导致术后并发症和死亡。传统的手臂袖带血压监测仪主要用于手术环境，但它不是侵入性的，袖带不能捕捉血压的突然变化。每年有超过5000万例手术进行，其中85%依赖于非连续血压臂袖带。该项目将开发一种新的可穿戴医疗设备，以非侵入性和连续地测量逐搏血压。该小型企业创新研究第一阶段项目将推进一种用于非侵入性和连续血压监测的新设备。 目前的设备受到其精度和时间分辨率的限制。所提出的医疗设备是基于软可穿戴压力传感器，解决了成本，准确性和时间分辨率的问题。 软传感器附着在身体上可触知脉搏的任何地方，并在脉搏波穿过动脉时测量皮肤表面上的动脉扩张。软传感器技术利用了微纳米结构褶皱电子薄膜的高弹性特性，该薄膜是使用一种新型的收缩制造工艺开发的。使用这些软可穿戴传感器的初步结果与黄金标准动脉线建立了高度相关性。该项目将开发电子设备，以无线方式读取和输出来自多个通道的信号，以及高度压敏的多通道传感器和腕带形状因子设计。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project aims to provide medical workers and consumers the utility of continuous blood pressure monitoring with an easy to use adhesive soft sensor, which can greatly improve personalized care and patient outcomes. While a patient is undergoing surgery, blood pressure is monitored because sudden drops have been linked to irreversible tissue and/or organ damage, resulting in post-operative complications and mortality. The traditional arm cuff blood pressure monitor is primarily used in surgical settings but while it is not invasive, the cuff doesn't capture sudden changes in blood pressure. There are more than 50 million surgeries are performed annually, 85% of which rely on non-continuous blood pressure arm cuffs. This project will develop a new wearable medical device to non-invasively and continuously measure beat-to-beat blood pressure. This Small Business Innovation Research Phase 1 project will advance a new device for non-invasive and continuously blood pressure monitoring. Current devices are limited by their accuracy and temporal resolution. The proposed medical device is based on soft wearable pressure sensors that solves the cost, accuracy, and temporal resolution problem. The soft sensor adheres to the body wherever a pulse is palpable and measures the arterial expansion on the surface of the skin as a pulse wave traverses the artery. Soft sensor technology leverages the highly elastic properties of micro-nanostructure wrinkled electronic thin films developed using a novel shrinking fabrication process. Preliminary results using these soft wearable sensors established high correlation to the gold standard arterial line. This project will develop electronics to read and output signals wirelessly from multiple channels as well as highly pressure-sensitive multichannel sensors and a wristband form factor design.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.