SBIR Phase I: A Beat-to-Beat Blood Pressure Monitor Using Micro-Nanoscale Wrinkled Functional Materials

这项小企业创新研究（SBIR）第一阶段项目的广泛影响/商业潜力旨在为医务工作者和消费者提供一种易于使用的粘性软传感器的连续血压监测，这可以极大地改善个性化护理和患者的治疗效果。当患者接受手术时，血压会受到监测，因为血压突然下降会导致不可逆的组织和/或器官损伤，从而导致术后并发症和死亡率。传统的袖带血压监测仪主要用于外科手术，虽然它没有侵入性，但袖带不能捕捉血压的突然变化。每年有超过5000万例手术，其中85%依赖于非连续血压臂套。该项目将开发一种新的可穿戴医疗设备，用于无创和连续测量心跳血压。这个小企业创新研究第一阶段项目将推进一种新的无创持续血压监测设备。目前的设备受到精度和时间分辨率的限制。提出的医疗设备基于软可穿戴压力传感器，解决了成本、精度和时间分辨率问题。软传感器附着在身体任何可以触摸到脉搏的地方，并在脉搏波穿过动脉时测量皮肤表面动脉的扩张。软传感器技术利用了微纳米结构皱褶电子薄膜的高弹性特性，该薄膜采用了一种新颖的收缩制造工艺。使用这些软可穿戴传感器的初步结果与金标准动脉线建立了高度相关。该项目将开发从多通道无线读取和输出信号的电子设备，以及高压敏感的多通道传感器和腕带外形设计。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project aims to provide medical workers and consumers the utility of continuous blood pressure monitoring with an easy to use adhesive soft sensor, which can greatly improve personalized care and patient outcomes. While a patient is undergoing surgery, blood pressure is monitored because sudden drops have been linked to irreversible tissue and/or organ damage, resulting in post-operative complications and mortality. The traditional arm cuff blood pressure monitor is primarily used in surgical settings but while it is not invasive, the cuff doesn't capture sudden changes in blood pressure. There are more than 50 million surgeries are performed annually, 85% of which rely on non-continuous blood pressure arm cuffs. This project will develop a new wearable medical device to non-invasively and continuously measure beat-to-beat blood pressure. This Small Business Innovation Research Phase 1 project will advance a new device for non-invasive and continuously blood pressure monitoring. Current devices are limited by their accuracy and temporal resolution. The proposed medical device is based on soft wearable pressure sensors that solves the cost, accuracy, and temporal resolution problem. The soft sensor adheres to the body wherever a pulse is palpable and measures the arterial expansion on the surface of the skin as a pulse wave traverses the artery. Soft sensor technology leverages the highly elastic properties of micro-nanostructure wrinkled electronic thin films developed using a novel shrinking fabrication process. Preliminary results using these soft wearable sensors established high correlation to the gold standard arterial line. This project will develop electronics to read and output signals wirelessly from multiple channels as well as highly pressure-sensitive multichannel sensors and a wristband form factor design.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.