The interplay between hedonic and hormonal stimuli in the central regulation of energy and glucose metabolism in humans (B02)

这个项目将描述享乐情绪和荷尔蒙刺激在调节人体内葡萄糖和能量与体重的平衡方面的相互作用。在第一个资助期，我们的数据揭示了视觉食物提示对男性葡萄糖代谢的影响，以及催产素的厌食和血糖调节潜力。在第二个资助期，我们将更深入地研究享乐刺激范式(视觉食物提示，“一起吃饭”)对男性葡萄糖代谢和食物摄入量的影响，以及鼻腔内催产素对瘦和肥胖女性这些参数的影响，以发现性别差异。在动物实验的基础上，我们还将研究加压素对人类摄食量的影响。通过结合“陪伴进食”和鼻内催产素，我们的目的是描述刺激性享乐成分和厌食激素成分对人类食物摄入量的影响。我们的结果将有助于制定治疗肥胖症的策略，这些肥胖症是由奖励处理功能障碍和高能量食物过剩引起的。

This project will characterize the interplay of hedonic-emotional and hormonal stimuli in the regulation of glucose and energy homeostasis in humans with respect to body weight. In the first funding period, our data revealed the impact of visual food cues on glucose metabolism as well as the anorectic and glucoregulatory potential of oxytocin in men. In the second funding period, we will closer investigate the impact of hedonic stimulatory paradigms (visual food cues, "eating in Company") on glucose metabolism and food intake in men as well as the impact of intranasal oxytocin on these parameters in lean and obese women to detect gender differences. Based on promising results in animals, we will also investigate the impact of vasopressin on food intake in humans. By combining “eating in company” and intranasal oxytocin, we aim at characterizing the impact of the stimulatory hedonic component and the anorectic hormonal component on food intake in humans. Our results will help to generate treatment strategies for obesity caused by dysfunction in reward-processing and by the surplus of energy-dense foods.