The interplay between hedonic and hormonal stimuli in the central regulation of energy and glucose metabolism in humans (B02)

人类能量和葡萄糖代谢中枢调节中的享乐刺激和激素刺激之间的相互作用（B02）

• 批准号: 244720909
• 金额: --
• 依托单位: Medizinische Klinik I
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/244720909?language=en
• 关键词: interplay; between; hedonic; hormonal; stimuli

This project will characterize the interplay of hedonic-emotional and hormonal stimuli in the regulation of glucose and energy homeostasis in humans with respect to body weight. In the first funding period, our data revealed the impact of visual food cues on glucose metabolism as well as the anorectic and glucoregulatory potential of oxytocin in men. In the second funding period, we will closer investigate the impact of hedonic stimulatory paradigms (visual food cues, "eating in Company") on glucose metabolism and food intake in men as well as the impact of intranasal oxytocin on these parameters in lean and obese women to detect gender differences. Based on promising results in animals, we will also investigate the impact of vasopressin on food intake in humans. By combining “eating in company” and intranasal oxytocin, we aim at characterizing the impact of the stimulatory hedonic component and the anorectic hormonal component on food intake in humans. Our results will help to generate treatment strategies for obesity caused by dysfunction in reward-processing and by the surplus of energy-dense foods.

这个项目将描述在人体内葡萄糖和能量平衡与体重的调节中，快乐情绪和激素刺激的相互作用。在第一个资助期，我们的数据揭示了视觉食物线索对葡萄糖代谢的影响，以及催产素在男性中的厌食和葡萄糖调节潜力。在第二个资助期，我们将更仔细地研究享乐刺激范式（视觉食物线索，“在公司吃饭”）对男性葡萄糖代谢和食物摄入的影响，以及鼻内催产素对瘦和肥胖女性这些参数的影响，以检测性别差异。基于在动物中的有希望的结果，我们还将研究加压素对人类食物摄入的影响。通过结合“在公司吃饭”和鼻内催产素，我们的目标是表征刺激享乐成分和厌食激素成分对人类食物摄入的影响。我们的研究结果将有助于制定治疗策略，治疗由奖励处理功能障碍和能量密集食物过剩引起的肥胖。