I-Corps: Stress Quantification Using Extended-Gate Sensing Technology

I-Corps：使用扩展门传感技术进行应力量化

• 批准号: 2041526
• 负责人: Jean Andrian
• 金额: $ 5万
• 依托单位: Florida International University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2022-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2041526&HistoricalAwards=false
• 关键词: Corps; Stress; Quantification; Using; Extended

The broader impact/commercial potential of this I-Corps project is the development of point-of-care device for monitoring stress levels in individuals working in high-stress environments. Psychological stress has important impact on physical health, but detecting and monitoring stress levels is difficult with current methods detecting trace amounts of chemicals in sweat or saliva. However, this is limited due to sensitivity, time, cost, portability, and reproducibility. The proposed technology provides early stress detection and communication through wireless connectivity. Potential users include athletes, military personnel, commercial pilots, and individuals with preexisting health conditions such as hypertension and cardiac dysfunction. The technology could be linked to other stakeholders in industries such as health care, insurance, and clinicians. This I-Corps project is based on the development of a point-of-care device for measuring cortisol hormone levels in sweat and saliva. The technology uses molecularly imprinted polymers (MIP) for sensing cortisol – a stress biomarker found in body fluids - by electrochemical detection, which is designed to quantitatively monitor and detect cortisol levels in real-time. An extended-gate field-effect transistor (EG-FET) is used as a transducer to detect the electrochemical response of MIPs and to take a direct readout from the sensor. This EG-FET cortisol sensing platform may be easily produced at an industrial scale with miniaturization and automation capabilities. The sensor will aid in low-cost clinical diagnostics by providing real-time visualization of cortisol biomarkers. The goal is to translate this device into an IoT device for wireless data transmission to a smartphone app to monitor cortisol levels.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目更广泛的影响/商业潜力是开发用于监测在高压力环境中工作的个人的压力水平的护理点设备。心理压力对身体健康有重要影响，但目前检测汗液或唾液中微量化学物质的方法很难检测和监测压力水平。然而，由于灵敏度、时间、成本、便携性和再现性，这受到限制。 所提出的技术通过无线连接提供早期压力检测和通信。潜在用户包括运动员、军事人员、商业飞行员以及患有高血压和心脏功能障碍等健康状况的个人。该技术可以与医疗保健、保险和临床医生等行业的其他利益相关者联系起来。 I-Corps 项目基于开发一种用于测量汗液和唾液中皮质醇激素水平的护理点设备。该技术使用分子印迹聚合物（MIP）通过电化学检测来感测皮质醇（体液中发现的一种压力生物标志物），旨在实时定量监测和检测皮质醇水平。扩展栅极场效应晶体管 (EG-FET) 用作传感器来检测 MIP 的电化学响应并从传感器直接读数。该 EG-FET 皮质醇传感平台可以轻松地以工业规模生产，具有小型化和自动化功能。该传感器将通过提供皮质醇生物标志物的实时可视化来帮助低成本的临床诊断。目标是将该设备转变为物联网设备，用于将数据无线传输到智能手机应用程序，以监测皮质醇水平。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，认为值得支持。