Doctoral Dissertation Research: Genetic and evolutionary determinants of the immune response in wild primates

博士论文研究:野生灵长类动物免疫反应的遗传和进化决定因素

基本信息

  • 批准号:
    2041621
  • 负责人:
  • 金额:
    $ 3.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-15 至 2023-03-31
  • 项目状态:
    已结题

项目摘要

Viruses and bacteria are thought to have played an important role in shaping primate evolution, but many open questions remain about how pathogens have acted to change primate genomes and influence trait diversity. More can be learned about the types of pathogens that have been most important in primate evolution, the types of genetic variants that have arisen to deal with these threats, and whether genetic variation in immune genes influences fitness-related traits in the present. This doctoral dissertation project studies the regulation of genes involved in immune defense in a wild primate system, focusing on an intensively studied population for which demographic, behavioral, and physiological data are also available. The doctoral student investigates how natural selection has shaped the gene expression response to pathogens in the past, and examines associations between immune-related gene expression variation, dominance rank, and other physiological characteristics. The project supports student mentorship and training opportunities, international research collaborations, and public science engagement through museum and conference events. The investigator measures genome-wide gene expression in either the presence or absence of stimuli that model bacterial or viral infection, for 160 individually recognized adult baboons. Differences in immune responses are examined for linkages to genetic differences between baboons, controlling for age, dominance rank, kinship, and other factors that also influence immune function. Integrating these findings with genome sequences from the same baboon population, the project investigates whether genes involved in the immune response to bacteria and/or viruses have been the target of historic or recent selection and tests whether genetic variation that influences the immune response also affects traits that are important to current physiological wellbeing and fitness.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
病毒和细菌被认为在塑造灵长类动物进化中发挥了重要作用,但关于病原体如何改变灵长类动物基因组和影响性状多样性的问题仍然存在。我们可以了解更多关于在灵长类进化中最重要的病原体类型,为应对这些威胁而出现的遗传变异类型,以及免疫基因中的遗传变异是否会影响目前与健康相关的性状。这个博士论文项目研究野生灵长类系统中参与免疫防御的基因的调控,重点是人口统计学,行为和生理数据也可获得的深入研究的人群。该博士生研究了自然选择如何塑造过去对病原体的基因表达反应,并研究了免疫相关基因表达变异,优势等级和其他生理特征之间的关联。该项目通过博物馆和会议活动支持学生导师和培训机会,国际研究合作以及公共科学参与。研究人员测量了160只单独识别的成年狒狒在存在或不存在模拟细菌或病毒感染的刺激物的情况下的全基因组基因表达。免疫反应的差异检查狒狒之间的遗传差异的联系,控制年龄,统治地位,亲属关系,以及其他因素,也影响免疫功能。将这些发现与来自同一狒狒种群的基因组序列相结合,该项目调查了是否有基因参与对细菌的免疫反应,或病毒一直是历史上或最近选择的目标,并测试影响免疫反应的遗传变异是否也影响对当前生理健康和健身重要的性状。该奖项反映了NSF的法定使命,并被认为是值得的。通过使用基金会的知识价值和更广泛的影响审查标准进行评估来提供支持。

项目成果

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会议论文数量(0)
专利数量(0)

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Jenny Tung其他文献

The biology of beauty sleep
美容睡眠的生物学原理
  • DOI:
    10.1038/s41559-022-01683-5
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    16.8
  • 作者:
    Jordan A Anderson;Jenny Tung
  • 通讯作者:
    Jenny Tung
A multi-million-year natural experiment
数百万年的自然实验
Agonism and grooming behavior explain social status effects on physiology and gene regulation in rhesus macaques
激动和梳理行为解释了社会地位对恒河猴生理和基因调控的影响
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    N. D. Simons;V. Michopoulos;M. Wilson;L. Barreiro;Jenny Tung
  • 通讯作者:
    Jenny Tung
K Locus Effects in Gray Wolves: Experimental Assessment of TLR3 Signaling and the Gene Expression Response to Canine Distemper Virus.
灰狼中的 K 基因座效应:TLR3 信号传导和对犬瘟热病毒的基因表达反应的实验评估。
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    3.1
  • 作者:
    Rachel A. Johnston;J. Rheinwald;B. Vonholdt;D. Stahler;Will F. Lowry;Jenny Tung;R. Wayne
  • 通讯作者:
    R. Wayne
Genetic evidence reveals temporal change in hybridization patterns in a wild baboon population
遗传证据揭示了野生狒狒种群杂交模式的时间变化
  • DOI:
  • 发表时间:
    2008
  • 期刊:
  • 影响因子:
    4.9
  • 作者:
    Jenny Tung;Marie J. E. Charpentier;Marie J. E. Charpentier;David A. Garfield;J. Altmann;S. Alberts
  • 通讯作者:
    S. Alberts

Jenny Tung的其他文献

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{{ truncateString('Jenny Tung', 18)}}的其他基金

Doctoral Dissertation Research: The phenotypic consequences of adaptive introgression in naturally hybridizing primates
博士论文研究:自然杂交灵长类动物适应性渐渗的表型后果
  • 批准号:
    2018897
  • 财政年份:
    2020
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research: Using natural hybridization to investigate patterns of primate gene regulation
博士论文研究:利用自然杂交研究灵长类动物基因调控模式
  • 批准号:
    1751783
  • 财政年份:
    2018
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Standard Grant
RAPID: Physiological and molecular mechanisms that explain reproductive-female-specific skeletal growth in a highly cooperative mammal, the Damaraland mole rat
RAPID:解释高度合作的哺乳动物达马拉兰鼹鼠生殖雌性特异性骨骼生长的生理和分子机制
  • 批准号:
    1749419
  • 财政年份:
    2017
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research: Effects of the Social Environment on DNA Methylation and Immune Function in Primates
博士论文研究:社会环境对灵长类动物DNA甲基化和免疫功能的影响
  • 批准号:
    1455808
  • 财政年份:
    2015
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Standard Grant
EAGER: New Methods for Genomic Analysis of Noninvasive Samples
EAGER:非侵入性样本基因组分析的新方法
  • 批准号:
    1405308
  • 财政年份:
    2014
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Standard Grant

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