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EAGER: Requisite lifetimes for coherent transition pathways in electron transfer flavoprotein: a quantum biology approach

EAGER：电子转移黄素蛋白中相干过渡途径的必要寿命：一种量子生物学方法

基本信息

批准号：
2051510
负责人：
Carlos Martino
金额：
$ 30万
依托单位：
Johns Hopkins University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-01 至 2021-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2051510&HistoricalAwards=false
关键词：
EAGER Requisite lifetimes coherent transition

项目摘要

One of the great challenges of modern science is to bridge the gap between atomic and cellular level phenomena that affect outcomes in living systems. A potentially transformational facet of this challenge is Quantum Biology: understanding how quantum properties play governing roles in biological functions. The overarching goal of this project seeks to apply theory-driven predictions of Quantum Biology for multi-scale integration of cellular function. The inter-disciplinary team proposes to use front-edge computational and modelling techniques in synergy with advanced magnetic resonance techniques to probe quantum coherent pathways in the biochemical activity of electron transfer flavoprotein (ETF) that controls the production of reactive oxygen species (ROS). ROS is a highly reactive species and its buildup in cell causes damages and eventual cell death. The project aims to use computational and experimental approaches to provide ground-breaking insights into the requisite lifetimes for quantum coherence in ETF and its role in ROS production. Connecting persistent quantum effects to cellular behaviors bridge the atomic and cellular levels. The project pursues research that challenges fundamental assumptions about educational and research approaches and aims to achieve a paradigm shift beyond multidisciplinary approaches in the way the next generation of students are educated and introduced to quantum research. Researchers and students will develop necessary skills to accelerate and integrate new knowledge to converge research at the emerging frontier of Quantum Biology.The project aims to connect broad spatio-temporal scales, from rapid dynamics at the molecular level to gradual ROS production at the macromolecular level. The project also focuses on a novel Quantum Biology area in cell redox biology: the activation of molecular oxygen by reduced flavoenzymes, where the production of reactive oxygen species can be described by manifestly quantum phenomena. Also included in this research is the development of the mathematical foundation of quantum optimal control with the ultimate goal of proving optimality condition in the form of Pontryagin’s maximum principle. This project is supported by the Molecular Biophysics cluster of the Molecular and Cellular Biosciences Division in the Directorate for Biological Sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

现代科学面临的最大挑战之一是弥合影响生命系统结果的原子和细胞水平现象之间的差距。这一挑战的一个潜在的转型方面是量子生物学：了解量子特性如何在生物功能中发挥主导作用。该项目的总体目标是将量子生物学的理论驱动预测应用于细胞功能的多尺度整合。跨学科团队建议使用前沿的计算和建模技术与先进的磁共振技术协同作用，以探测电子转移黄素蛋白（ETF）的生化活性中的量子相干途径，该蛋白控制活性氧（ROS）的产生。ROS是一种高度反应性的物质，其在细胞中的积累会导致损伤和最终的细胞死亡。该项目旨在使用计算和实验方法，为ETF中量子相干性的必要寿命及其在ROS生产中的作用提供突破性的见解。将持续的量子效应与细胞行为联系起来，在原子和细胞水平之间架起了桥梁。该项目追求挑战教育和研究方法的基本假设的研究，旨在实现超越多学科方法的范式转变，以教育下一代学生并将其引入量子研究。研究人员和学生将培养必要的技能，以加速和整合新知识，以融合量子生物学新兴前沿的研究。该项目旨在连接广泛的时空尺度，从分子水平的快速动力学到大分子水平的逐步ROS产生。该项目还专注于细胞氧化还原生物学中的一个新的量子生物学领域：通过还原黄素酶激活分子氧，其中活性氧的产生可以通过明显的量子现象来描述。本研究也包括量子最优控制的数学基础的发展，其最终目标是以庞特里亚金最大值原理的形式证明最优性条件。该项目由生物科学理事会分子和细胞生物科学部的分子生物物理学小组支持。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。