RCN: Creating and Fostering the Plant Cell Atlas Community

RCN：创建和培育植物细胞图谱社区

基本信息

批准号：
2052590
负责人：
Seung Rhee
金额：
$ 76.54万
依托单位：
Carnegie Institution of Washington
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2024-04-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2052590&HistoricalAwards=false
关键词：
RCN Creating Fostering Plant Cell

项目摘要

Rapid climate change and other environmental factors are increasing societal demands for plant-based solutions from scientists and engineers. The long-term goal of the Plant Cell Atlas (PCA) community is to build a comprehensive map of the locations, interactions, and functions of molecules in plant cells and tissues to accelerate both fundamental research and meeting societal challenges. The PCA community will set standards for generating and integrating large plant data sets that will ultimately contribute to the foundation of synthesizing how biology works at the cellular level. The RCN will establish and nurture the community that will ultimately generate data and infrastructure for the PCA. This RCN will also provide excellent networking and interdisciplinary training opportunities for early career scientists and outreach to K-12 students and the general public about the importance and fascination of plants. The PCA community will emphasize broadening participation of scientists and students from underserved communities by providing financial support for participating in workshops and events and establishing a strong presence on campuses of Historically Black Colleges and Universities (HBCUs) via a travelling scientific art exhibit, among other initiatives. Future generations of scientists trained by the RCN will pioneer innovative and sustainable solutions to mitigate and overcome food, materials, and energy shortages expected to result from climate change.Many questions in fundamental, translational, and applied plant biology await answers, requiring both new data and analytical frameworks that make connections among disparate data types. Rapid advances in technologies are being made in synthetic biology, genome engineering, robotics, artificial intelligence, structural biology, mass spectrometry, and microscopy. These technologies are being applied to plants to dissect the functions and interactions of specialized cell types and their capacity to respond to environmental stresses, host symbioses, and to produce useful products. However, the information provided by these new technologies will be most powerful if it is integrated and standardized to provide fresh insights into the functional connections among diverse biomolecules, to suggest new hypotheses for cellular functions, and to model cellular processes. The community established through this RCN will pioneer the integration of large, diverse plant datasets into a Plant Cell Atlas that will ultimately enable innovative and sustainable solutions to the challenges expected from climate change. The RCN will: 1) develop rubrics for defining plant cell types; 2) provision networking and training opportunities for the PCA community, especially for early career participants through workshops, webinars, and symposia; 3) establish guidelines and best practices for data integration, resulting in standardized data collection protocols and analysis methods; 4) facilitate the generation of new methods for image annotation/analysis driven by connections to the artificial intelligence community; 5) develop the PCA website as a central platform where scientists can find experimental protocols, community standards, and links to available resources; and 6) foster collaborations on research and grant applications for generating data, developing tools, and creating computational infrastructures. This award is being co-funded by the Cellular Dynamics and Function and the Genetic Mechanisms clusters of the Division of Molecular and Cellular Biosciences, along with the Plant, Fungal and Microbial Developmental Mechanisms Program and the Plant Genome Research Program of the Division of Integrative and Organismal Systems.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

迅速的气候变化和其他环境因素正在增加对科学家和工程师的基于植物解决方案的社会需求。植物细胞图集（PCA）社区的长期目标是建立植物细胞和组织中分子的位置，相互作用和功能的综合图，以加速这两个基本研究并满足社会挑战。 PCA社区将设定标准，以生成和集成大型工厂数据集，最终将有助于综合生物学在细胞水平上的工作方式。 RCN将建立和培育社区，最终为PCA生成数据和基础架构。该RCN还将为早期职业科学家提供出色的网络和跨学科培训机会，并向K-12学生和公众推广植物的重要性和迷恋。 PCA社区将通过为参与研讨会和活动提供财务支持，并通过旅行科学艺术展览在历史悠久的黑人学院和大学（HBCUS）校园内建立强大的校园来强调扩大服务不足社区的科学家和学生的参与。由RCN培训的后代科学家将开创创新和可持续的解决方案，以减轻和克服由气候变化导致的食物，材料和能源短缺。在气候变化中预期的问题。在基本，转化和应用植物生物学方面的许多问题等待着答案，需要新的数据和分析框架，以使差异数据类型之间有联系。在合成生物学，基因组工程，机器人技术，人工智能，结构生物学，质谱和显微镜中，技术的快速进步正在做出。这些技术被应用于植物，以剖析专用细胞类型的功能和相互作用及其对环境压力，宿主共生和生产有用产品的反应能力。但是，如果将这些新技术的信息集成和标准化，以提供有关各种生物分子之间功能连接的新见解，以提出针对细胞功能的新假设以及对细胞过程进行建模的新假设，则这些新技术提供的信息将最强大。通过此RCN建立的社区将开创大型植物数据集中融入植物细胞地图集的社区，最终将使创新和可持续的解决方案能够应对气候变化所期望的挑战。 RCN将：1）开发用于定义植物细胞类型的标题； 2）为PCA社区提供网络和培训机会，尤其是通过研讨会，网络研讨会和研讨会的早期职业参与者； 3）建立数据集成的准则和最佳实践，从而产生标准化的数据收集协议和分析方法； 4）促进由与人工智能界的联系驱动的图像注释/分析的新方法； 5）开发PCA网站作为中央平台，科学家可以找到实验协议，社区标准和可用资源的链接； 6）促进有关生成数据，开发工具和创建计算基础架构的研究和授予应用程序的合作。该奖项是由细胞动力学和功能以及分子和细胞生物科学划分的遗传机制以及植物，真菌和微生物发育机制计划以及植物基因组研究计划以及综合和有机体的植物基因组研究计划的遗传机制的群体，这些奖项反映了NSF的范围和跨国公司的范围。标准。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Vision, challenges and opportunities for a Plant Cell Atlas.

DOI：
10.7554/elife.66877
发表时间：
2021-09-07
期刊：
eLife
影响因子：
7.7
作者：
Plant Cell Atlas Consortium;Jha SG;Borowsky AT;Cole BJ;Fahlgren N;Farmer A;Huang SC;Karia P;Libault M;Provart NJ;Rice SL;Saura-Sanchez M;Agarwal P;Ahkami AH;Anderton CR;Briggs SP;Brophy JA;Denolf P;Di Costanzo LF;Exposito-Alonso M;Giacomello S;Gomez-Cano F;Kaufmann K;Ko DK;Kumar S;Malkovskiy AV;Nakayama N;Obata T;Otegui MS;Palfalvi G;Quezada-Rodríguez EH;Singh R;Uhrig RG;Waese J;Van Wijk K;Wright RC;Ehrhardt DW;Birnbaum KD;Rhee SY
通讯作者：
Rhee SY

Renaming Indigenous crops and addressing colonial bias in scientific language

DOI：
10.1016/j.tplants.2022.08.022
发表时间：
2022-11-09
期刊：
TRENDS IN PLANT SCIENCE
影响因子：
20.5
作者：
Dwyer, William;Ibe, Carol N.;Rhee, Seung Y.
通讯作者：
Rhee, Seung Y.

Recognizing pioneering Black plant scientists in our schools and society

表彰我们学校和社会中的黑人植物科学家先驱

DOI：
10.1016/j.tplants.2021.07.021
发表时间：
2021
期刊：
Trends in Plant Science
影响因子：
20.5
作者：
Eckelbarger, Maxwell;Rice, Selena L.;Osano, Anne;Peng, Jiangnan;Ullah, Hemayet;Rhee, Seung Y.
通讯作者：
Rhee, Seung Y.

The Plant Cell Atlas: focusing new technologies on the kingdom that nourishes the planet