IL-22 and IL-22BP in liver regeneration and carcinogenesis (C08)

我们的初步和已发表的数据表明，IL-22在再生和致癌作用中具有保护性和致病性。因此，严格控制IL-22是必不可少的。这种控制是通过调节IL-22的产生和IL-22 BP（一种内源性IL-22抑制剂）来实现的。我们假设IL-22和IL-22 BP在肝脏中的协调表达对于控制IL-22的局部和暂时作用以及因此的肝再生和癌变是必不可少的。我们的目标是使用小鼠模型来验证这一假设，并确定调节IL-22和IL-22 BP的机制。

Our preliminary and published data indicate that IL-22 has both protective and pathogenic properties in regeneration and carcinogenesis. Thus, strict control of IL-22 is essential. This control is exerted via regulation of IL-22 production and by IL-22BP, an endogenous IL-22 inhibitor. We hypothesize that coordinated expression of IL-22 and IL-22BP in the liver is essential to control the local and temporal effects of IL-22 and thus liver regeneration and carcinogenesis. Our goal is to test this hypothesis using mouse models and to identify the mechanisms regulating IL-22 and IL-22BP.