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Design, synthesis, and evaluation of antimony-based anion transporters

锑基阴离子转运蛋白的设计、合成和评估

基本信息

批准号：
2108728
负责人：
Francois Gabbai
金额：
$ 45万
依托单位：
Texas A&M University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2108728&HistoricalAwards=false
关键词：
Design synthesis evaluation antimony based

项目摘要

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the Division of Chemistry, Professor François Gabbaï of Texas A&M University will investigate a class of compounds that may serve as transporter of negatively charged ions across artificial membranes that resemble those found in living cells. This project will study how the ion transport properties of these compounds can be influenced by their molecular constitution or by application of external stimulations. Altogether, this project will likely lead to the creation of new fundamental knowledge in the biologically relevant area of ion transport while contributing to the education of students from diverse backgrounds. The principal investigator and his group will also engage elementary school students into the areas of science and technology through outreach activities involving K-6 students from Spanish/English dual language programs. Finally, this project will also allow the principal investigator to remain involved in various service activities, including the mentoring of socioeconomically disadvantaged high school students.This research project will investigate both neutral and charged antimony-Lewis acids for the transport of fluoride and chloride anions across phospholipid membranes of artificial vesicles. By synthesizing and investigating a structurally differentiated library of antimony derivatives, this research aims to uncover the multidimensional relationships connecting the anion transport properties of these cations in artificial vesicles to the hydrophobicity of their structures, the Lewis acidity of the antimony center, and the steric bulk present around the anion binding site. Establishing these relationships will add key elements needed to gain an understanding of the vast compositional space within which these transporters can exist, thus enabling the design of new derivatives with tailored anion transport properties. This project will also explore antimony-based transporters that can be actuated by external stimuli such as redox agents or metal ions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系的大分子，超分子和纳米化学项目的支持下，德克萨斯A M大学的François Gabbaiti教授将研究一类化合物，这些化合物可以作为带负电荷的离子穿过类似于活细胞中发现的人工膜的转运蛋白。本项目将研究这些化合物的离子传输特性如何受到其分子结构或外部刺激的影响。总而言之，该项目可能会导致在离子传输的生物相关领域创造新的基础知识，同时有助于来自不同背景的学生的教育。首席研究员和他的小组还将通过涉及西班牙语/英语双语课程的K-6学生的外联活动，让小学生参与科学和技术领域。最后，该项目还将允许主要研究者继续参与各种服务活动，包括指导社会经济上处于不利地位的高中生。该研究项目将研究中性和带电的锑-路易斯酸，用于运输氟离子和氯离子穿过人工囊泡的磷脂膜。通过合成和研究锑衍生物的结构差异库，本研究旨在揭示连接这些阳离子在人工囊泡中的阴离子传输特性与其结构的疏水性、锑中心的刘易斯酸性和阴离子结合位点周围存在的空间体积的多维关系。建立这些关系将增加所需的关键元素，以了解这些转运蛋白可能存在的巨大组成空间，从而能够设计具有定制阴离子转运特性的新衍生物。该项目还将探索可由氧化还原剂或金属离子等外部刺激激活的锑基转运体。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。