NSF Postdoctoral Fellowship in Biology FY 2021: : Investigating the roles of epigenetic and genomic variation through time in the invasion success of Japanese white-eye

2021 财年 NSF 生物学博士后奖学金::研究表观遗传和基因组变异随时间的推移在日本绣眼鸟入侵成功中的作用

基本信息

  • 批准号:
    2109692
  • 负责人:
  • 金额:
    $ 13.8万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Fellowship Award
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-01 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2021, Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, Environment and Phenotypes. The fellowship supports research and training of the fellow that will contribute to the area of Rules of Life in innovative ways. The introduction of non-native species in an environment can have significant problematic effects on many native species in that environment. Therefore, a main goal of invasion biology is to understand what makes a species a successful invader. Understanding the genetics of invasive species is considered extremely important to understanding what makes a species a successful invader. This project will focus on epigenetic mechanisms for invasive species. Epigenetic mechanisms can regulate gene expression, and therefore an individual’s phenotype, without any change in DNA sequence. As it becomes increasingly clear that epigenetic mechanisms play an important role in species responses to changing environments, it is essential to assess how epigenetic mechanisms themselves evolve. The nascent field of historical epigenetics, or the epigenetics of museum specimens, provides an exciting opportunity to study the evolution of epigenetic mechanisms. Understanding the genetic and epigenetic characteristics of species can help predict its capacity for invasion, and therefore provide information that can aid in mitigating the negative effects of species introductions.The primary objective of this research is to investigate the relative roles epigenetic and genomic variation in invasion success, focusing on the Japanese white-eye (Zosterops japonicus), also known as the warbling white-eye. Z. japonicus, a bird native to East Asia, was introduced to Hawaii in the early 1900s and has since become the most abundant bird on the islands. This study will use whole genome sequencing and modern and historical epigenetics to 1) characterize current levels of genomic and epigenetic divergence in native and invasive populations of Z. japonicus, 2) assess how genomic and epigenetic divergence changed over time in these populations, and 3) characterize epigenetic variation in genes involved in immune response to avian malaria, a disease that has decimated native Hawaiian bird populations but Z. japonicus shows resistance to. This research tests the central hypothesis that epigenetic variation plays a large role in early colonization by an invasive species but that over time the pathways become robust, and populations show increased genomic divergence.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这一行动为NSF 2021财年生物学博士后研究奖学金提供了资金,综合研究调查了支配基因组、环境和表型之间相互作用的生命规则。该奖学金支持研究员的研究和培训,这些研究员将以创新的方式为生活规则领域做出贡献。在一个环境中引入非本土物种可能会对该环境中的许多本土物种产生重大问题。因此,入侵生物学的一个主要目标是了解是什么让一个物种成为成功的入侵者。了解入侵物种的遗传学被认为对了解是什么使一个物种成为成功的入侵者极其重要。该项目将重点研究入侵物种的表观遗传机制。表观遗传机制可以调节基因表达,从而调节个体的表型,而不会改变DNA序列。随着表观遗传机制在物种对环境变化的反应中发挥重要作用变得越来越明显,评估表观遗传机制本身是如何进化的至关重要。历史表观遗传学的新兴领域,或博物馆标本的表观遗传学,为研究表观遗传学机制的进化提供了一个令人兴奋的机会。了解物种的遗传和表观遗传特征有助于预测其入侵能力,从而提供有助于减轻物种引进的负面影响的信息。本研究的主要目的是研究表观遗传和基因组变异在入侵成功中的相对作用,重点关注日本白眼(Zosterops Japan Onicus),也被称为颤白眼。日本麻雀是一种原产于东亚的鸟类,于20世纪初被引入夏威夷,此后成为该岛上数量最多的鸟类。这项研究将使用全基因组测序和现代和历史表观遗传学来1)表征日本原生和入侵种群的基因组和表观遗传分化的当前水平,2)评估这些种群的基因组和表观遗传差异是如何随着时间的推移而变化的,以及3)表征参与禽流感免疫反应的基因的表观遗传变异。禽流感已经导致夏威夷本地鸟类种群大量死亡,但日本斑潜蝇对这种疾病表现出抗药性。这项研究测试了核心假设,即表观遗传变异在入侵物种的早期殖民中发挥了很大作用,但随着时间的推移,途径变得健壮,种群显示出更大的基因组差异。这一奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

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Madhvi Venkatraman其他文献

Population genomics of recovery and extinction in Hawaiian honeycreepers
夏威夷管舌鸟恢复与灭绝的种群基因组学
  • DOI:
    10.1016/j.cub.2025.04.078
  • 发表时间:
    2025-06-09
  • 期刊:
  • 影响因子:
    7.500
  • 作者:
    Christopher C. Kyriazis;Madhvi Venkatraman;Bryce Masuda;Cynthia C. Steiner;Loren Cassin-Sackett;Lisa H. Crampton;Alison M. Flanagan;Jeffrey T. Foster;Marlys L. Houck;Ann C. Misuraca;Eben H. Paxton;Jacqueline A. Robinson;Robert C. Fleischer;Oliver A. Ryder;Michael G. Campana;Aryn P. Wilder
  • 通讯作者:
    Aryn P. Wilder

Madhvi Venkatraman的其他文献

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