NSF Postdoctoral Fellowship in Biology FY 2021: Replaying the tape of Genotype-Phenotype Evolution: Integrating Evidence of Climbing Habit Evolution across Alstroemeriaceae

2021 财年 NSF 生物学博士后奖学金：重播基因型-表型进化的磁带：整合六出花科攀爬习惯进化的证据

• 批准号: 2109835
• 负责人: Carrie Tribble
• 金额: $ 21.6万
• 依托单位: Tribble, Carrie M
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2109835&HistoricalAwards=false
• 关键词: NSF; Postdoctoral; Fellowship; Biology; FY

This action funds an NSF Plant Genome Postdoctoral Research Fellowship in Biology for FY 2021. The fellowship supports a research and training plan in a host laboratory for the Fellow who also presents a plan to broaden participation in biology. The title of the research and training plan for this fellowship to Carrie M. Tribble is "Replaying the tape of Genotype-Phenotype Evolution: Integrating Genetic, Anatomical, and Phylogenetic Evidence of Climbing Habit Evolution across Alstroemeriaceae" The host institution for the fellowship is the University of Hawai`i at Manoa and the Universidad de Antioquia (Colombia) and the sponsoring scientists are Dr. Rosana Zenil-Ferguson and Dr. Fernando Alzate-Guarín.Different species occasionally evolve the same feature independently. This process, called convergent evolution, can occur in distantly or closely related species and may be due to different or similar changes in the underlying DNA. Often, convergent evolution occurs when distinct species evolve in response to similar environments. To better understand how and why convergent evolution occurs, this research will gather data on the convergent evolution of climbing vines and model how changes in the environment where plants grow and modifications to DNA can lead to the evolution of shared, independently evolved features. Training objectives include acquiring new skills in mathematical modeling, fieldwork, plant anatomy and systematics. Support through this fellowship will provide new opportunities for the Fellow to train students through two educational programs: a Spanish-language undergraduate and graduate student methods course at partner institutions in Colombia and an educational botany internship program for high school students at Lyon Arboretum at the University of Hawai`i. Convergent and parallel evolution have generated some of the most iconic examples of environmental pressures driving phenotypes, including the mind-boggling similarity of distantly related succulent plants, the extraordinary ability to fly among vertebrate and invertebrate animals, and the novel emergence of antibiotic-resistance in bacteria despite the lack of resistance in common ancestors. Yet, despite the importance of these processes in producing much of the observed phenotypic variation, knowledge of the genomic and environmental factors that generate repeated phenotypes is lacking. It is still unknown to what extent “convergence” at the morphological level is matched by convergence at the anatomical or molecular level. To better understand how repeated phenotypes are produced, the project will include detailed studies on a botanical family – Alstroemeriaceae – with clear variation in the climbing habit, a repeated phenotype and key innovation in flowering plants. Through three aims, this research will characterize the detailed environmental, morphological, anatomical, and genetic underpinnings of this habit and test the hypothesis that shared genetic, environmental, and anatomical changes are responsible for the evolution of climbing by: (1) developing a novel model for identifying the molecular basis of repeated phenotypic evolution; (2) modeling the evolution of stem anatomy and environments of climbing and non-climbing plants; and (3) implementing the new model to identify the genetic underpinnings of climbing in Alstroemeriaceae. The data generated by this project include (1) field-measured environmental variables, (2) herbarium vouchers, (3) stem anatomy descriptions over a developmental series, (4) evolutionary relationships (phylogenies) of Alstroemeriaceae, (5) genome-level genetic sequences (RADSeq regions), and (6) a whole genome of Luzuriaga radicans. All data will be made publicly available through online data repositories such as NCBI, TreeBASE, and Data Dryad. Keywords: convergent evolution, climbing, Alstroemeriaceae, phylogenetic comparative methodsThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该行动为2021财年的生物学生物学研究奖学金提供了一项NSF植物基因组基因组研究奖学金。该奖学金支持该研究员的主机实验室研究和培训计划，该研究员还提出了扩大生物学参与的计划。 The title of the research and training plan for this fellowship to Carrie M. Tribble is "Replaying the tape of Genotype-Phenotype Evolution: Integrating Genetic, Anatomical, and Phylogenetic Evidence of Climbing Habit Evolution across Alstroemeriaceae" The host institution for the fellowship is the University of Hawai`i at Manoa and the Universidad de Antioquia (Colombia) and the sponsoring scientists are Dr. Rosana Zenil-Ferguson和Fernando alzate-Guarín博士有时独立地发展相同的特征。这种称为收敛进化的过程可能发生在远或密切相关的物种中，可能是由于基础DNA的不同或类似的变化所致。通常，当不同的物种响应类似的环境而变化时，会融合进化。为了更好地了解融合进化的方式以及为什么发生，这项研究将收集有关攀爬藤蔓的收敛演化的数据，并模拟植物生长的环境变化以及对DNA的修改会导致共享，独立发展的特征的演变。培训对象包括获得数学建模，野外工作，植物解剖学和系统学的新技能。通过这项奖学金的支持将为同胞提供新的机会，以通过两个教育计划培训学生：哥伦比亚合作伙伴机构的西班牙语本科和研究生方法课程，以及夏威夷大学里昂河畔里昂河畔高中生的教育植物学实习计划。融合和平行的进化产生了驱动表型的环境压力的一些最具标志性的例子，包括与明显相关的肉质植物的令人难以置信的相似性，在脊椎动物和无脊椎动物中飞行的非凡能力，以及细菌使命中抗生素抗性的新出现在共同祖先中缺乏抵抗。然而，使命这些过程在产生许多观察到的表型变异中的重要性，了解产生重复表型的基因组和环境因素。在形态学水平上的“收敛”程度与解剖学或分子水平的收敛相匹配。为了更好地了解如何产生重复的表型，该项目将包括有关植物科的详细研究-Alstroemeriaceae-具有攀岩习惯，重复的表型和开花植物的关键创新的明显变化。通过三个目标，这项研究将表征这种习惯的详细环境，形态，解剖和遗传基础，并检验了共享遗传，环境和解剖学变化共享的假设，这些变化是由以下方式造成的：（1）开发一种新型模型，以确定重复现象型型进化的分子基础； （2）建模茎解剖结构的演变以及攀岩和非攀爬植物的环境； （3）实施新模型以识别alstroemeriaceae攀岩的遗传基础。该项目生成的数据包括（1）野外测量的环境变量，（2）标志凭证，（3）在发育系列中的茎解剖学描述，（4）alstroemeriaceae的进化关系（系统发育），（5）基因组级遗传序列（5）基因组遗传序列（RADSEQ区域（RADSEQ区域）（RADSEQ区域）和（6）ARADARANE and lu kut ric ric ric ric ric。所有数据将通过在线数据存储库（例如NCBI，Treebase和Data Dryad）公开获得。关键词：融合进化，攀岩，alstroemeriaceae，系统发育比较方法该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，被认为是通过评估而被视为珍贵的支持。

项目成果

Commonly used Bayesian diversification methods lead to biologically meaningful differences in branch-specific rates on empirical phylogenies

常用的贝叶斯多样化方法导致经验系统发育的分支特定率具有生物学意义的差异

• DOI: 10.1093/evlett/qrad044
• 发表时间: 2023
• 期刊: Evolution Letters
• 影响因子: 5
• 作者: Martínez-Gómez, Jesús;Song, Michael J.;Tribble, Carrie M.;Kopperud, Bjørn T.;Freyman, William A.;Höhna, Sebastian;Specht, Chelsea D.;Rothfels, Carl J.
• 通讯作者: Rothfels, Carl J.

The rapid radiation of Bomarea (Alstroemeriaceae: Liliales), driven by the rise of the Andes

• DOI: 10.1093/evolut/qpad184
• 发表时间: 2023-10-13
• 期刊: EVOLUTION
• 影响因子: 3.3
• 作者: Tribble，Carrie M.;Alzate-Guarin，Fernando;Rothfels，Carl J.
• 通讯作者: Rothfels，Carl J.