NSF Postdoctoral Fellowship in Biology FY 2021: Quality over Quantity: Uncovering the genetic mechanisms linking egg quality to fitness.

2021 财年 NSF 生物学博士后奖学金：质量重于数量：揭示将卵子质量与健康联系起来的遗传机制。

• 批准号: 2109854
• 负责人: Patricka Williams-Simon
• 金额: $ 13.8万
• 依托单位: Williams-Simon, Patricka
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2109854&HistoricalAwards=false
• 关键词: NSF; Postdoctoral; Fellowship; Biology; FY

This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2021, Broadening Participation of Groups Under-represented in Biology. The Fellowship supports a research and training plan for the Fellow that will increase the participation of groups underrepresented in biology. Species survival depends upon offspring surviving to adulthood, to pass their genes unto the next generation. Current research demonstrates maternally derived egg nutritive content such as some fats and proteins, can impact offspring survival. Most importantly, studies show survival is profoundly influenced by altered egg nutritive content. What remains unclear however, are the genes responsible for egg content and survivorship, and whether there is a genetic correlation between egg size and quality and offspring viability. This research proposes to successfully identify the genetic relationship between egg size, egg quality, and offspring. Identifying genes that control these traits is important for understanding fundamental evolutionary and ecological questions regarding the importance of egg quality and its influence on species survival. Furthermore, findings from this proposed study can be used as building blocks to better understand human related reproductive difficulties. This research’s broader impact initiative would provide underrepresented undergraduate students the opportunity to conduct scientific research and participate in other science related workshops and meetings. This initiative was developed to address current low numbers of underrepresented individuals in STEM fields. Participants will be exposed to a variety of training opportunities, while acquiring technical experience and mentorship alongside the fellow, a Black, female scientist.This study combines QTL mapping with classical genetics and evolutionary and re-sequencing approaches, allowing for the comprehensive discovery of genes influencing complex egg traits critical for fitness. This research will test the hypothesis that there are various and large effects on genomic loci that regulate egg content, and that egg content, size, and offspring viability have a positive linear genetic relationship. The postdoctoral level initiative attached to the project is developed to establish the first university-wide Black postdoctoral organization, Blacks Supporting Blacks in STEM (BSBS). Member scholars of this organization will build a robust relationship with local communities, establish networking platforms, and create mentor/mentee pipelines to provide social support and possible research collaborations.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项行动资助了2021财年的NSF生物学博士后研究奖学金，扩大了生物学中代表性不足的群体的参与。该研究金支持研究员的一项研究和培训计划，该计划将增加在生物学领域代表性不足的群体的参与。物种的生存依赖于后代存活到成年，将他们的基因传递给下一代。目前的研究表明，母体来源的鸡蛋营养成分，如一些脂肪和蛋白质，会影响后代的生存。最重要的是，研究表明，鸡蛋营养成分的改变对存活率有着深刻的影响。然而，目前尚不清楚的是负责卵子含量和存活率的基因，以及卵子大小和质量与后代生存能力之间是否存在遗传相关性。这项研究旨在成功地确定鸡蛋大小，鸡蛋质量和后代之间的遗传关系。确定控制这些性状的基因对于理解关于蛋质量的重要性及其对物种生存的影响的基本进化和生态问题是重要的。此外，这项拟议研究的结果可以作为更好地了解人类相关生殖困难的基石。这项研究的更广泛的影响倡议将提供代表性不足的本科生进行科学研究和参加其他科学相关的研讨会和会议的机会。这项倡议是为了解决目前STEM领域代表性不足的人数。参与者将接触到各种培训机会，同时获得技术经验和导师一起研究员，黑人，女科学家.这项研究结合了QTL作图与经典遗传学和进化和重新测序的方法，允许全面发现基因影响复杂的鸡蛋性状的健身至关重要.这项研究将测试的假设，有各种各样的和大的影响基因组位点，调节鸡蛋含量，鸡蛋含量，大小和后代的生存能力有一个积极的线性遗传关系。该项目的博士后水平倡议旨在建立第一个大学范围内的黑人博士后组织，黑人支持黑人干（BSBS）。该组织的成员学者将与当地社区建立稳固的关系，建立网络平台，并创建导师/学员管道，以提供社会支持和可能的研究合作。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。