MRI: Acquisition of a New X-Ray Diffractometer to Advance Research and Education in Primarily Undergraduate/Minority Serving Institutions within the District of Columbia

该奖项授予哥伦比亚特区大学（UDC），由主要研究仪器和化学研究仪器项目提供支持，以支持和改进宋雪青博士及其同事王磊、Ozlem Dilek、Uche Udeochu和Alexandra Taraboletti的研究。该机构正在购买单晶x射线衍射仪（SCXRD）。一般来说，x射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于邻近分子的空间排列的准确信息。这里描述的研究影响许多领域，包括有机和无机化学，材料化学，地质和生物化学。该仪器是这所历史悠久的黑人学院和大学（HBCU）以及华盛顿特区其他机构（如美国天主教大学、美利坚大学、加劳德特大学和三一华盛顿大学）化学和生物化学本科生教学、研究和研究培训的一个组成部分。该仪器为分布在各个系的各种课程的学生提供了直接的研究经验。为期一周的暑期学院旨在为UDC和合作机构提供正式的晶体学实践培训。颁发x射线衍射仪的目的是为了加强各级的研究和教育。通过将铜螯合剂铜酮的金属酶靶点的生物功能和结构研究结合起来，通过探索材料的界面现象和生物重要化合物的结构-活性动力学，该仪器提供了相关的社会效益。铜螯合剂铜酮抑制单胺氧化酶并导致肝和脑损伤。该仪器还用于研究三有机锡配合物与含蛋白酶的硫醇之间的相互作用，荧光探针用于成像氧化应激诱导的巨噬细胞脂质过氧化产物。衍射仪还用于研究自旋交叉配合物和基于风化石的地聚合，以供原位资源利用。该仪器还为研究抗菌、抗病毒药物和脂蛋白代谢调节剂的研究人员以及分析矿物沉淀技术用于生物介导的地面改善的研究人员提供服务。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award to the University of the District of Columbia (UDC) is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs to support and improve research by Dr. Xueqing Song and colleagues Lei Wang, Ozlem Dilek, Uche Udeochu and Alexandra Taraboletti. This institution is acquiring a single crystal X-ray difffractometer (SCXRD). In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry, geology and biochemistry. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this Historically Black College and University (HBCU) as well as the other institution in the DC area such as the Catholic University of America, American University, Gallaudet University and Trinity Washington University. The instrumentation provides direct research experience for students in a variety of courses distributed in various departments. A one-week summer institute is designed to provide UDC and partner institutions formal and hands-on training in crystallography.The award of the X-ray diffractometer is aimed at enhancing research and education at all levels. The science enabled by this instrument provides relevant societal benefits by associating biofunctional and structural studies of the metalloenzymatic targets of the copper chelator cuprizone that inhibits monoamine oxidase and causes liver and brain damage and by exploring interfacial phenomena of materials and structure-activity dynamics of biologically significant compounds. The instrumentation is also used for studying interactions between triorganotin complexes and thiol containing protease and fluorescent probes for imaging oxidative stress-induced lipid peroxidation products of macrophages. The diffractometer is also employed to carry out investigations of spin crossover complexes and regolith-based geopolymerization for in-situ resource utilization. The instrument also serves researchers studying antibacterial, antiviral agents and lipoprotein metabolism modulators and those analyzing mineral precipitation techniques for biomediated ground improvement.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.