MRI: Acquisition of a New X-Ray Diffractometer to Advance Research and Education in Primarily Undergraduate/Minority Serving Institutions within the District of Columbia

MRI:购买新型 X 射线衍射仪,以推进哥伦比亚特区内主要本科/少数族裔服务机构的研究和教育

基本信息

  • 批准号:
    2117621
  • 负责人:
  • 金额:
    $ 32.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

This award to the University of the District of Columbia (UDC) is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs to support and improve research by Dr. Xueqing Song and colleagues Lei Wang, Ozlem Dilek, Uche Udeochu and Alexandra Taraboletti. This institution is acquiring a single crystal X-ray difffractometer (SCXRD). In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry, geology and biochemistry. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this Historically Black College and University (HBCU) as well as the other institution in the DC area such as the Catholic University of America, American University, Gallaudet University and Trinity Washington University. The instrumentation provides direct research experience for students in a variety of courses distributed in various departments. A one-week summer institute is designed to provide UDC and partner institutions formal and hands-on training in crystallography.The award of the X-ray diffractometer is aimed at enhancing research and education at all levels. The science enabled by this instrument provides relevant societal benefits by associating biofunctional and structural studies of the metalloenzymatic targets of the copper chelator cuprizone that inhibits monoamine oxidase and causes liver and brain damage and by exploring interfacial phenomena of materials and structure-activity dynamics of biologically significant compounds. The instrumentation is also used for studying interactions between triorganotin complexes and thiol containing protease and fluorescent probes for imaging oxidative stress-induced lipid peroxidation products of macrophages. The diffractometer is also employed to carry out investigations of spin crossover complexes and regolith-based geopolymerization for in-situ resource utilization. The instrument also serves researchers studying antibacterial, antiviral agents and lipoprotein metabolism modulators and those analyzing mineral precipitation techniques for biomediated ground improvement.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这一奖项授予哥伦比亚特区大学(UDC),由重大研究仪器和化学研究仪器项目支持,以支持和改进宋学青博士及其同事王雷、Ozlem Dilek、Uche Udeochu和Alexandra Tarboletti的研究。该机构正在获得一台单晶X射线衍射仪。通常,X射线衍射仪可以准确和精确地测量分子的完整三维结构,包括键距离和角度,并提供关于分子相对于邻近分子的空间排列的准确信息。这里描述的研究影响到许多领域,包括有机化学和无机化学、材料化学、地质学和生物化学。该仪器是这所历史悠久的黑人学院和大学(HBCU)以及华盛顿特区其他机构,如美国天主教大学、美国大学、加洛德特大学和三一华盛顿大学化学和生物化学本科生教学、研究和研究培训的组成部分。该仪器为学生提供了直接的研究经验,在各种课程分布在不同的部门。为期一周的暑期学院旨在为UDC和伙伴机构提供结晶学方面的正式和实践培训。授予X射线衍射仪旨在加强各级的研究和教育。该仪器提供的科学提供了相关的社会效益,通过将铜络合剂铜试剂金属酶靶标的生物功能和结构研究结合起来,通过探索材料的界面现象和具有生物意义的化合物的结构-活性动力学,铜络合剂抑制单胺氧化酶并导致肝脏和大脑损伤。该仪器还用于研究三有机锡络合物与含有硫醇的蛋白酶和荧光探针之间的相互作用,以成像巨噬细胞氧化应激诱导的脂质过氧化产物。该衍射仪还被用于研究自旋交叉络合物和基于风化石的地聚反应,以实现就地资源利用。该仪器还服务于研究抗菌、抗病毒药物和脂蛋白新陈代谢调节剂的研究人员,以及那些分析矿物沉淀技术以进行生物改良的研究人员。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Xueqing Song其他文献

New trimethyltin(IV) derivatives of dipeptides: synthesis, characteristic spectral studies and biological activity
新型二肽三甲基锡(IV)衍生物:合成、特征光谱研究和生物活性
  • DOI:
    10.1002/aoc.698
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    3.9
  • 作者:
    M. Nath;Sandeep Pokharia;G. Eng;Xueqing Song;Ashok Kumar;M. Gielen;R. Willem,;M. Biesemans,
  • 通讯作者:
    M. Biesemans,
Tolerance of various biological species to triorganotins
各种生物物种对三有机锡的耐受性
  • DOI:
    10.3233/mgc-140139
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    R. Far;Hirut Yimer;José H. Delao Hernández;J. Ferguson;Adewola Osunsade;J. Hoerner;R. Knighton;J. Robinson;Stephanie M. Graves;Xueqing Song;R. Pike;G. Eng
  • 通讯作者:
    G. Eng
Synthesis, spectroscopic and structural characterization of diphenyltin(IV) complexes of acetone Schiff bases of <em>S</em>-alkyldithiocarbazates
  • DOI:
    10.1016/j.poly.2007.11.030
  • 发表时间:
    2008-02-26
  • 期刊:
  • 影响因子:
  • 作者:
    Mohammad Akbar Ali;Aminul Huq Mirza;Malai Haniti S.A. Hamid;Paul V. Bernhardt;Olaniran Atchade;Xueqing Song;George Eng;Leopold May
  • 通讯作者:
    Leopold May
Synthesis, Structure–Activity Relationship of Some New Triorganotin(IV) Derivatives of Dipeptides as Anti-Inflammatory Agents
一些新型抗炎二肽三有机锡(IV)衍生物的合成及构效关系
Interaction of organotin(IV) moieties with nucleic acid constituent: Synthesis, structural characterization and anti-inflammatory activity of tri-i-propyltin(IV) and diorganotin(IV) derivatives of guanosine
有机锡(IV)部分与核酸成分的相互作用:鸟苷三异丙基锡(IV)和二有机锡(IV)衍生物的合成、结构表征和抗炎活性
  • DOI:
    10.1016/j.inoche.2011.05.027
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    3.8
  • 作者:
    M. Nath;H. Singh;G. Eng;Xueqing Song
  • 通讯作者:
    Xueqing Song

Xueqing Song的其他文献

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{{ truncateString('Xueqing Song', 18)}}的其他基金

MRI: Acquisition of a 400 MHz FT-NMR For Undergraduate Research and Education at the University of the District of Columbia
MRI:哥伦比亚特区大学采购 400 MHz FT-NMR 用于本科生研究和教育
  • 批准号:
    1040094
  • 财政年份:
    2010
  • 资助金额:
    $ 32.16万
  • 项目类别:
    Standard Grant

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