MRI: Acquisition of Advanced Solid-State NMR Instrumentation to Investigate Novel Biological & Engineered Materials at CCNY

MRI：购买先进的固态 NMR 仪器来研究新型生物

• 批准号: 2117799
• 负责人: Ruth Stark
• 金额: $ 83.33万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2117799&HistoricalAwards=false
• 关键词: MRI; Acquisition; Advanced; Solid; State

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. CUNY City College (CCNY) is upgrading a console for solid state nuclear magnetic resonance (ssNMR) spectrometer that is equipped with an advanced control system for solid-state NMR experiments and a pulsed field high-gradient (PFG) NMR broadband diffusion probe. The instrument supports the research of Professor Ruth Stark, Robert Messinger and other colleagues. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of chemically and biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in chemistry and biochemistry at this institution as well as collaborators from neighboring colleges. This advanced solid-state NMR instrumentation at CCNY facilitates new collaborations among molecular biophysicists and chemical engineers who target both natural and designed materials, laying the groundwork for activities that share technical expertise, seed partnerships and disseminate scientific advances. This instrument is also employed in educational activities such as half-day workshops among CCNY ssNMR users that share technical expertise, illustrate research applications and foster student communication skills. An annual NMR poster session brings together ssNMR practitioners from the NYC region and a hands-on outreach workshop using ssNMR projects to spark the interest of undergraduate students in STEM, especially those from underrepresented groups.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts investigations on pigments and polyesters that protect cells and studies of molecular environments and structures of inorganic battery materials. The instrumentation is also used to enable the study of lipids and membrane proteins in complex biomembranes and the study of tension-dependent dynamics in designed and natural elastin fibers which are an essential component of extracellular matrices. In addition, it the instrument allows investigations of ion storage in molecular organic electrode materials for use in batteries, and allows studies of protein-mediated signaling.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划共同支持。CUNY City College（CCNY）正在升级固态核磁共振（ssNMR）光谱仪的控制台，该控制台配备了固态核磁共振实验的先进控制系统和脉冲场高梯度（PFG）核磁共振宽带扩散探头。该仪器支持Ruth Stark教授，Robert Messinger和其他同事的研究。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及允许研究化学和生物学相关物种。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。该仪器是该机构化学和生物化学本科生和研究生以及邻近学院合作者的教学和研究及研究培训的组成部分。CCNY的这种先进的固态核磁共振仪器促进了分子生物物理学家和化学工程师之间的新合作，他们针对天然和设计材料，为分享技术专业知识、种子合作伙伴关系和传播科学进步的活动奠定了基础。该仪器还用于教育活动，如CCNY ssNMR用户之间的半天研讨会，分享技术专长，说明研究应用和培养学生的沟通技能。每年的NMR海报会议汇集了来自纽约地区的ssNMR从业者，并使用ssNMR项目的实践推广研讨会，以激发本科生对STEM的兴趣，特别是那些来自代表性不足的群体。NMR光谱仪的奖项旨在加强各级的研究和教育。它特别影响了对保护电池的颜料和聚酯的研究，以及对无机电池材料的分子环境和结构的研究。该仪器还用于研究复杂生物膜中的脂质和膜蛋白，以及研究设计和天然弹性蛋白纤维中的张力依赖性动力学，弹性蛋白纤维是细胞外基质的重要组成部分。此外，该仪器还可用于电池中分子有机电极材料的离子存储研究，以及蛋白质介导信号的研究。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。