RCN-UBE: Bringing CRISPR-Cas9 technologies to the undergraduate classroom: an undergraduate instructors' network

RCN-UBE：将 CRISPR-Cas9 技术引入本科生课堂：本科生导师网络

• 批准号: 2120417
• 负责人: Donna Pattison
• 金额: $ 49.92万
• 依托单位: University of Houston
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2120417&HistoricalAwards=false
• 关键词: RCN; UBE; Bringing; CRISPR; Cas9

The CRISPR in the Classroom Network seeks to expand current undergraduate laboratory curriculum to include CRISPR-Cas9 gene editing technology. In the last decade, CRISPR-Cas9 has become a mainstream technique in molecular biology, and a basic understanding of the methodology is essential for our undergraduates to enter research careers workforce-ready. However, as is the case with any new technology, course instructors need access to training, professional development opportunities, and support to bring CRISPR-Cas9 into their curricula, which is not always readily available. This CRISPR in the Classroom network will provide flexible, easily adapted curriculum and mentoring to instructors and start-up kits to overcome the hurdles associated with learning and testing new curriculum in class. The objectives of the program include the development of a national network of biology educators at both two- and four-year institutions dedicated to the development and implementation of laboratory activities centered on experiential-based work with CRISPR-Cas9 and the creation of an online repository of CRISPR-Cas9 based modules across multiple model systems through the NSF-Supported Quantitative Undergraduate Biology Education and Synthesis (QUBES) Hub. A series of workshops will be offered to instructors, postdoctoral fellows, and graduate students to provide the necessary training and mentoring needed to be comfortable implementing CRISPR-Cas9 into the curriculum. As instructors modify the curriculum to fit their institutions and resources, the QUBES site will provide a central, searchable location to share their work where other laboratory instructors can find modules and a community of support as they work to ensure their undergraduate curriculum is on the cutting-edge of science. This project is being jointly funded by the Directorate for Biological Sciences, Division of Biological Infrastructure, and the Directorate for Education and Human Resources (EHR), Division of Undergraduate Education as part of their efforts to address the challenges posed in Vision and Change in Undergraduate Biology Education: A Call to Action (http://visionandchange/finalreport/). This project is also supported by the NSF HSI and and IUSE:EHR programs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

CRISPR课堂网络旨在扩大目前的本科实验课程，将CRISPR- cas9基因编辑技术纳入其中。在过去的十年中，CRISPR-Cas9已经成为分子生物学的主流技术，对其方法论的基本了解对于我们的本科生进入研究职业队伍至关重要。然而，与任何新技术一样，课程讲师需要获得培训、专业发展机会和支持，才能将CRISPR-Cas9纳入他们的课程，而这些并不总是容易获得的。课堂CRISPR网络将提供灵活、易于调整的课程，并为教师提供指导和启动工具包，以克服与课堂学习和测试新课程相关的障碍。该计划的目标包括在两年制和四年制院校建立一个全国性的生物教育工作者网络，致力于开发和实施以CRISPR-Cas9为中心的实验活动，并通过nsf支持的定量本科生物学教育和综合中心（QUBES）建立一个跨多个模型系统的基于CRISPR-Cas9模块的在线存储库。将为讲师、博士后研究员和研究生提供一系列研讨会，以提供必要的培训和指导，以便在课程中轻松实施CRISPR-Cas9。当教师修改课程以适应他们的机构和资源时，QUBES网站将提供一个中央的、可搜索的位置来分享他们的工作，在那里其他实验室教师可以找到模块和支持社区，因为他们的工作确保他们的本科课程处于科学的前沿。该项目由生物基础设施司生物科学理事会和本科教育司教育和人力资源理事会共同资助，作为其应对《本科生物学教育的愿景与变革：行动呼吁》（http://visionandchange/finalreport/）所提出的挑战的努力的一部分。本项目也得到了NSF HSI和IUSE:EHR项目的支持。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。