COLLABORATIVE RESEARCH: GCR: Characterization and Robust Multivariable Control of the Dynamics of Gas Exchange During Peritoneal Oxygenated Perfluorocarbon Perfusion

合作研究：GCR：腹膜全氟化碳灌注过程中气体交换动力学的表征和鲁棒多变量控制

• 批准号: 2121101
• 负责人: Joseph Friedberg
• 金额: $ 138.13万
• 依托单位: University of Maryland at Baltimore
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-10-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2121101&HistoricalAwards=false
• 关键词: COLLABORATIVE; RESEARCH; GCR; Characterization; Robust

This Growing Convergence Research project addresses the critical societal need to develop a lung-independent technique for providing respiratory support to patients with respiratory failure from disorders such as COVID-19. Extracorporeal membrane oxygenation (ECMO) is the only such technique currently available, but is an expensive and scarce resource with complications that preclude it as an option for many patients, even when it is available. This project will develop a “third lung” technology that achieves lung-independent gas exchange by circulating oxygenated perfluorocarbon (PFC, a safe, inert liquid with extraordinary gas-dissolving properties) through the abdominal cavity. This is a convergent research project that integrates bioengineering and control theory with physiology to create a technology with the potential to save thousands of lives every year.Preliminary research results supported with an NSF EAGER award demonstrate potentially life-saving degrees of oxygenation and CO2 clearance. This project will push the research boundaries in three specific directions: (i) the development of a multi-functional fiber-optic sensor capable of measuring dissolved gas concentrations in PFC, as well as PFC temperature and pressure; (ii) the use of both benchtop and animal experiments to further characterize and model the fundamental dynamics of “third lung” gas exchange; and (iii) the development of novel robust multivariable control algorithms for the “third lung”, facilitating its potential implementation as a routine adjunct in the treatment of patients with respiratory failure. This convergent research portfolio will bring together a diverse research team from the fields of biomedical engineering, sensing, automatic control, and medicine in pursuit of research with high potential societal impact.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个“日益融合的研究”项目解决了开发一种独立于肺的技术的关键社会需求，为因 COVID-19 等疾病导致呼吸衰竭的患者提供呼吸支持。 体外膜肺氧合（ECMO）是目前唯一可用的此类技术，但它是一种昂贵且稀缺的资源，并且存在并发症，使得许多患者无法选择它，即使它是可用的。 该项目将开发一种“第三肺”技术，通过将含氧全氟化碳（PFC，一种安全的惰性液体，具有非凡的气体溶解特性）循环通过腹腔，实现不依赖于肺的气体交换。 这是一个融合研究项目，将生物工程和控制理论与生理学相结合，创造出一种每年有可能挽救数千人生命的技术。获得 NSF EAGER 奖支持的初步研究结果表明，氧合和二氧化碳清除具有潜在的挽救生命的程度。该项目将在三个具体方向上推动研究边界：(i) 开发能够测量 PFC 中溶解气体浓度以及 PFC 温度和压力的多功能光纤传感器； (ii) 使用台式和动物实验来进一步表征和模拟“第三肺”气体交换的基本动力学； (iii) 为“第三肺”开发新型稳健的多变量控制算法，促进其作为呼吸衰竭患者治疗的常规辅助手段的潜在实施。 这一融合的研究组合将汇集来自生物医学工程、传感、自动控制和医学领域的多元化研究团队，以追求具有高潜在社会影响力的研究。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。