COLLABORATIVE RESEARCH: GCR: Characterization and Robust Multivariable Control of the Dynamics of Gas Exchange During Peritoneal Oxygenated Perfluorocarbon Perfusion
合作研究:GCR:腹膜全氟化碳灌注过程中气体交换动力学的表征和鲁棒多变量控制
基本信息
- 批准号:2121101
- 负责人:
- 金额:$ 138.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-10-01 至 2022-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This Growing Convergence Research project addresses the critical societal need to develop a lung-independent technique for providing respiratory support to patients with respiratory failure from disorders such as COVID-19. Extracorporeal membrane oxygenation (ECMO) is the only such technique currently available, but is an expensive and scarce resource with complications that preclude it as an option for many patients, even when it is available. This project will develop a “third lung” technology that achieves lung-independent gas exchange by circulating oxygenated perfluorocarbon (PFC, a safe, inert liquid with extraordinary gas-dissolving properties) through the abdominal cavity. This is a convergent research project that integrates bioengineering and control theory with physiology to create a technology with the potential to save thousands of lives every year.Preliminary research results supported with an NSF EAGER award demonstrate potentially life-saving degrees of oxygenation and CO2 clearance. This project will push the research boundaries in three specific directions: (i) the development of a multi-functional fiber-optic sensor capable of measuring dissolved gas concentrations in PFC, as well as PFC temperature and pressure; (ii) the use of both benchtop and animal experiments to further characterize and model the fundamental dynamics of “third lung” gas exchange; and (iii) the development of novel robust multivariable control algorithms for the “third lung”, facilitating its potential implementation as a routine adjunct in the treatment of patients with respiratory failure. This convergent research portfolio will bring together a diverse research team from the fields of biomedical engineering, sensing, automatic control, and medicine in pursuit of research with high potential societal impact.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个日益融合的研究项目解决了开发一种肺独立技术的关键社会需求,为COVID-19等疾病导致的呼吸衰竭患者提供呼吸支持。体外膜氧合(ECMO)是目前唯一可用的这种技术,但它是一种昂贵且稀缺的资源,即使在可用的情况下,其并发症也使其无法作为许多患者的选择。该项目将开发一种“第三肺”技术,通过腹腔循环含氧全氟碳(PFC,一种具有非凡气体溶解性能的安全惰性液体),实现与肺无关的气体交换。这是一个融合了生物工程、控制理论和生理学的研究项目,旨在创造一种每年有可能拯救数千人生命的技术。初步研究结果得到了美国国家科学基金会EAGER奖的支持,证明了可能挽救生命的氧化和二氧化碳清除程度。该项目将在三个具体方向上推动研究边界:(i)开发一种多功能光纤传感器,能够测量PFC中的溶解气体浓度,以及PFC的温度和压力;(ii)利用实验台和动物实验,进一步描述和模拟“第三肺”气体交换的基本动态;(iii)为“第三肺”开发新的鲁棒多变量控制算法,促进其作为治疗呼吸衰竭患者的常规辅助手段的潜在实现。这种融合的研究组合将汇集来自生物医学工程、传感、自动控制和医学领域的不同研究团队,以追求具有高潜在社会影响的研究。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Joseph Friedberg其他文献
P2.06-041 TeleNursing: A Thoracic Surgery Nursing Initiative Aimed at Decreasing Hospital Readmissions and Increasing Patient Satisfaction: Topic: LAB, Other
- DOI:
10.1016/j.jtho.2016.11.1534 - 发表时间:
2017-01-01 - 期刊:
- 影响因子:
- 作者:
Melissa Culligan;Joseph Friedberg;Lindsey Black;Seantrese Wimbush;Colleen Norton;Whitney Burrows;Shamus Carr;James Donahue;Marc Zubrow - 通讯作者:
Marc Zubrow
SPONTANEOUS SPLENIC RUPTURE IN A DIFFUSE MALIGNANT MESOTHELIOMA
- DOI:
10.1016/j.chest.2019.08.1191 - 发表时间:
2019-10-01 - 期刊:
- 影响因子:
- 作者:
Jingjing Chen;Joseph Friedberg;Melissa Culligan;Ashutosh Sachdeva;Edward Pickering;Van Holden;Christian Rolfo - 通讯作者:
Christian Rolfo
Clinical application of an IR navigation system for pleural PDT
- DOI:
10.1016/j.pdpdt.2011.03.061 - 发表时间:
2011-06-01 - 期刊:
- 影响因子:
- 作者:
T. Zhu;X. Liang;C. Chang;J. Finlay;A. Dimofte;K. Cengel;Joseph Friedberg;E. Glatstein;S. Hahn - 通讯作者:
S. Hahn
BRONCHIAL STUMP-PLEURAL FISTULA TREATED WITH SILVER-NITRATE
- DOI:
10.1016/j.chest.2019.08.1373 - 发表时间:
2019-10-01 - 期刊:
- 影响因子:
- 作者:
Akshay Kohli;Divyansh Bajaj;Amrik Ray;Edward Pickering;Van Holden;Ashutosh Sachdeva;Joseph Friedberg - 通讯作者:
Joseph Friedberg
Lung volume reduction surgery is safe and leads to functional improvement in patients who fail or cannot undergo bronchoscopic lung volume reduction
- DOI:
10.1016/j.xjon.2024.02.004 - 发表时间:
2024-04-01 - 期刊:
- 影响因子:
- 作者:
Jessica Magarinos;Aron Egelko;Gerard J. Criner;Abbas Abbas;Nosayaba Enofe;JiJi Thomas;Kevin Carney;Joseph Friedberg;Charles Bakhos - 通讯作者:
Charles Bakhos
Joseph Friedberg的其他文献
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{{ truncateString('Joseph Friedberg', 18)}}的其他基金
COLLABORATIVE RESEARCH: GCR: Characterization and Robust Multivariable Control of the Dynamics of Gas Exchange During Peritoneal Oxygenated Perfluorocarbon Perfusion
合作研究:GCR:腹膜全氟化碳灌注过程中气体交换动力学的表征和鲁棒多变量控制
- 批准号:
2227939 - 财政年份:2021
- 资助金额:
$ 138.13万 - 项目类别:
Continuing Grant
EAGER/Collaborative Research: Experimentally Validated Modeling of the Dynamics of Carbon Dioxide Removal from the Bloodstream via Peritoneal Perfluorocarbon Circulation
EAGER/合作研究:通过腹膜全氟化碳循环从血流中去除二氧化碳的动力学模型经过实验验证
- 批准号:
2031245 - 财政年份:2020
- 资助金额:
$ 138.13万 - 项目类别:
Standard Grant
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