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Collaborative Research: GCR: Characterization and Robust Multivariable Control of the Dynamics of Gas Exchange During Peritoneal Oxygenated Perfluorocarbon Perfusion

合作研究：GCR：腹膜全氟化碳灌注过程中气体交换动力学的表征和鲁棒多变量控制

基本信息

批准号：
2121110
负责人：
Hosam Fathy
金额：
$ 216万
依托单位：
University of Maryland, College Park
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2021
资助国家：
美国
起止时间：
2021-10-01 至 2027-09-30
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2121110&HistoricalAwards=false
关键词：
Collaborative Research GCR Characterization Robust

项目摘要

This Growing Convergence Research project addresses the critical societal need to develop a lung-independent technique for providing respiratory support to patients with respiratory failure from disorders such as COVID-19. Extracorporeal membrane oxygenation (ECMO) is the only such technique currently available, but is an expensive and scarce resource with complications that preclude it as an option for many patients, even when it is available. This project will develop a “third lung” technology that achieves lung-independent gas exchange by circulating oxygenated perfluorocarbon (PFC, a safe, inert liquid with extraordinary gas-dissolving properties) through the abdominal cavity. This is a convergent research project that integrates bioengineering and control theory with physiology to create a technology with the potential to save thousands of lives every year.Preliminary research results supported with an NSF EAGER award demonstrate potentially life-saving degrees of oxygenation and CO2 clearance. This project will push the research boundaries in three specific directions: (i) the development of a multi-functional fiber-optic sensor capable of measuring dissolved gas concentrations in PFC, as well as PFC temperature and pressure; (ii) the use of both benchtop and animal experiments to further characterize and model the fundamental dynamics of “third lung” gas exchange; and (iii) the development of novel robust multivariable control algorithms for the “third lung”, facilitating its potential implementation as a routine adjunct in the treatment of patients with respiratory failure. This convergent research portfolio will bring together a diverse research team from the fields of biomedical engineering, sensing, automatic control, and medicine in pursuit of research with high potential societal impact.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个日益融合的研究项目解决了关键的社会需求，即开发一种非肺依赖性技术，为COVID-19等疾病导致的呼吸衰竭患者提供呼吸支持。体外膜肺氧合（ECMO）是目前唯一可用的此类技术，但它是一种昂贵且稀缺的资源，并发症使其无法作为许多患者的选择，即使它可用。该项目将开发一种“第三肺”技术，通过在腹腔中循环含氧全氟化碳（PFC，一种具有非凡气体溶解特性的安全惰性液体），实现非肺依赖性气体交换。这是一个融合了生物工程和控制理论与生理学的研究项目，旨在创造一种每年有可能挽救数千人生命的技术。获得NSF EAGER奖支持的初步研究结果证明了氧合和CO2清除的潜在救生程度。该项目将在三个具体方向上推动研究范围：（一）开发能够测量PFC中溶解气体浓度以及PFC温度和压力的多功能光纤传感器;（二）利用台式和动物实验进一步描述“第三肺”气体交换的基本动力学并建立模型;以及（iii）为“第三肺”开发新的鲁棒多变量控制算法，促进其作为呼吸衰竭患者治疗中的常规辅助手段的潜在实施。该研究项目将汇集来自生物医学工程、传感、自动控制和医学等领域的多元化研究团队，致力于具有高潜在社会影响力的研究。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响力审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Experimental Parameterization of a Model of Hypoxia Dynamics in Yorkshire Swine

约克夏猪缺氧动力学模型的实验参数化

DOI：
10.1016/j.ifacol.2022.11.272
发表时间：
2022
期刊：
IFAC-PapersOnLine
影响因子：
0
作者：
Wood, Sam;Commins, Annina;Doosthosseini, Mahsa;Naselsky, Warren;Culligan, Melissa;Aroom, Kevin;Aroom, Majid;Kadkhodaeielyaderani, Behzad;Moon, Yejin;Leibowitz, Joshua
通讯作者：
Leibowitz, Joshua

Modeling the Impact of Abdominal Pressure on Hypoxia in Laboratory Swine

模拟腹压对实验猪缺氧的影响

DOI：
10.1115/1.4063478
发表时间：
2023
期刊：
ASME Letters in Dynamic Systems and Control
影响因子：
0
作者：
KadkhodaeiElyaderani, Behzad;Leibowitz, Joshua L.;Moon, Yejin;Stachnik, Stephen;Awad, Morcos;Sarkar, Grace M.;Shaw, Anna E.;Stewart, Shelby;Culligan, Melissa;Friedberg, Joseph S.
通讯作者：
Friedberg, Joseph S.

On the Fisher Identifiability of Coupled Transport Processes in Animal Hypoxia Experiments

动物缺氧实验中耦合传输过程的 Fisher 可识别性

DOI：
10.1109/lcsys.2023.3344146
发表时间：
2023
期刊：
IEEE Control Systems Letters
影响因子：
3
作者：
Abdelazim, Eman M.;Fathy, Hosam K.
通讯作者：
Fathy, Hosam K.

An Extended Kalman Filter for Retained Volume Estimation in Peritoneal Perfusion Applications

用于腹膜灌注应用中保留体积估计的扩展卡尔曼滤波器

DOI：
10.1109/ccta49430.2022.9966128
发表时间：
2022
期刊：
IEEE Conference on Control Technology and Applications
影响因子：
0
作者：
Moon, Yejin;Doosthosseini, Mahsa;Kadkhodaeielyaderani, Behzad;Friedberg, Joseph S.;Hahn, Jin-Oh;Fathy, Hosam K.
通讯作者：
Fathy, Hosam K.

213 Extrapulmonary Gas Exchange Through Peritoneal Perfluorocarbon Perfusion