PFI-RP: Partnership for Innovation - Avoiding Kidney Injuries with Evidence-Based Smart Technology

PFI-RP：创新合作——利用循证智能技术避免肾脏损伤

• 批准号: 2122901
• 负责人: Erica Forzani
• 金额: $ 55万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2122901&HistoricalAwards=false
• 关键词: PFI; RP; Partnership; Innovation; Avoiding

The broader impact/commercial potential of this Partnerships for Innovation – Research Partnerships (PFI-RP) project is to develop a new technology that improves the ability of doctors to diagnose acute kidney injury in hospitalized patients. Acute kidney injury is a medical condition which begins without clinical symptoms or signs, and has been estimated to occur in up to 20% of hospitalized patients. Acute kidney injury results in significant harm to patients as well as greatly increased overall health care costs. Acute kidney injury is generally not recognized early in its course. Currently available methods used to diagnose acute kidney injury are imperfect. Recognition of acute kidney injury using presently available methods is delayed and only occurs after the development of significant organ dysfunction. The technology that will be developed in this PFI-RP project may detect acute kidney injury earlier so that treatment can be rendered.This project will develop a new technology for continuous, real time measurement and real time analysis of urinary biomarkers of acute kidney injury. Specifically, a system for continuous measurement of urine components will be developed and built. This system will be used to measure and quantify urine components and develop a model of early acute kidney injury. A machine learning prediction model will be developed and tested with the model system.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该创新-研究伙伴关系（PFI-RP）项目的更广泛影响/商业潜力是开发一种新技术，提高医生诊断住院患者急性肾损伤的能力。急性肾损伤是一种开始时没有临床症状或体征的医学状况，据估计发生在高达20%的住院患者中。急性肾损伤对患者造成严重伤害，并大大增加了整体医疗保健费用。急性肾损伤通常在病程早期无法识别。目前用于诊断急性肾损伤的方法是不完善的。使用目前可用的方法识别急性肾损伤是延迟的，并且仅发生在发生显著的器官功能障碍之后。PFI-RP项目将开发的技术可以更早地检测急性肾损伤，从而提供治疗。本项目将开发一种新的技术，用于急性肾损伤尿液生物标志物的连续、真实的时间测量和真实的时间分析。具体而言，将开发和构建用于连续测量尿液成分的系统。该系统将用于测量和定量尿液成分，并建立早期急性肾损伤模型。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。