PFI-RP: Development of a Temperature-Sensitive, High-Adhesion Medical Tape for Reducing Pain, Skin Injury, and Dislodgement of Critical Devices for Children in Hospitals
PFI-RP:开发一种温度敏感、高粘性医用胶带,用于减轻医院儿童的疼痛、皮肤损伤和关键设备的移位
基本信息
- 批准号:2234356
- 负责人:
- 金额:$ 55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The broader impact/commercial potential of this Partnerships for Innovation – Research Partnerships (PFI-RP) project is reducing medical adhesive related skin injuries and device dislodgement events. Medical adhesives are used to secure wound care dressings and other critical devices to the skin. Although stronger adhesives can provide a higher level of securement, they are difficult to painlessly remove from the skin and may cause medical-adhesive-related skin injuries, which include skin tears and an increased risk of infection. This project will develop higher adhesion medical tapes, whereby the adhesion can be reduced for removal with the application of heat. This ability to remove easily will significantly reduce the risk of skin injury and subsequent infections while simultaneously providing the high adhesion required for secure attachment of medical devices during hospital care, reducing device dislodgement events and improving the quality of care. If successful, this solution will save over $1 billion annually in healthcare by preventing skin injury and critical device dislodgement. The project will train promising technical professionals in translational entrepreneurship with close mentorship from industry. The proposed project will provide a chemical and physical understanding of temperature responsive adhesives required for high adhesion medical tape that can avoid both skin injury during tape removal and accidental device dislodgement. Current medical tapes do not have a temperature sensitive component to enable higher adhesion coupled with easier release. Initial prototypes have demonstrated an adhesive tape with a substantial temperature-responsive release attribute. Fully understanding the mechanism for this release could impact the development of stimuli-responsive adhesives that could be used for a wide range of medical and nonmedical applications. The major goals of this project are the following: (a) gain a fundamental knowledge of the release mechanism, (b) transfer to a high-volume manufacturing process to demonstrate scaling feasibility, (c) verify these high-volume manufacturing prototypes retain performance after storage with several pilot studies, (d) gain approval for testing in a nearby children’s hospital, and (e) train promising professionals in entrepreneurship and translational team science. This project will facilitate the fabrication of prototypes in a high-volume manufacturing environment that will outperform the current state-of-the-art medical tapes. In addition, highly skilled emerging professionals will receive training in the transition from pilot to high-volume product manufacturing and packaging.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该创新-研究合作伙伴关系(PFI-RP)项目的更广泛影响/商业潜力是减少医用粘合剂相关皮肤损伤和器械脱位事件。医用粘合剂用于将伤口护理敷料和其他关键设备固定到皮肤上。虽然更强的粘合剂可以提供更高水平的固定,但它们难以从皮肤上无痛地移除,并且可能导致与医疗粘合剂相关的皮肤损伤,包括皮肤撕裂和感染风险增加。该项目将开发更高粘附力的医用胶带,通过加热可以减少粘附力。这种易于移除的能力将显著降低皮肤损伤和后续感染的风险,同时提供在医院护理期间医疗器械的牢固附接所需的高粘附性,减少器械移位事件并提高护理质量。如果成功,该解决方案将通过防止皮肤损伤和关键设备移位,每年节省超过10亿美元的医疗保健费用。该项目将在工业界的密切指导下,培训有前途的技术专业人员从事转化型创业。拟议的项目将提供高粘性医用胶带所需的温度响应粘合剂的化学和物理理解,可避免胶带移除过程中的皮肤损伤和意外器械移位。目前的医用胶带不具有温度敏感组分,以实现更高的粘附性和更容易的释放。最初的原型已经证明了具有显著的温度响应释放属性的胶带。充分了解这种释放的机制可能会影响可用于广泛医疗和非医疗应用的刺激响应粘合剂的开发。该项目的主要目标如下:(a)获得释放机制的基本知识,(B)转移到大批量制造过程以证明缩放的可行性,(c)通过几个试点研究验证这些大批量制造原型在储存后保持性能,(d)获得在附近儿童医院进行测试的批准,以及(e)在创业和转化团队科学方面培训有前途的专业人员。该项目将促进在大批量制造环境中制造原型,其性能将超过目前最先进的医用胶带。此外,高技能的新兴专业人员将接受培训,从试点到大批量产品制造和包装的过渡。该奖项反映了NSF的法定使命,并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Eric Seibel其他文献
1389 TOWARDS SEMI AUTOMATED CYSTOSCOPIC EXAMINATION OF THE BLADDER: MERGING SCANNING FIBER ENDOSCOPE TECHNOLOGY WITH IMAGE PANORAMIC STITCHING SOFTWARE
- DOI:
10.1016/j.juro.2011.02.1236 - 发表时间:
2011-04-01 - 期刊:
- 影响因子:
- 作者:
Michael Porter;Timothy Soper;Eric Seibel - 通讯作者:
Eric Seibel
TCT-222 Types of Arterial Calcifications by Laser Angioscopy
- DOI:
10.1016/j.jacc.2022.08.262 - 发表时间:
2022-09-20 - 期刊:
- 影响因子:
- 作者:
Sarosh Irfan Madhani;Jorge Arturo Larco;Yang Liu;Quinton Reade;Eric Seibel;Luis Savastano - 通讯作者:
Luis Savastano
HIGH-RESOLUTION ANGIOSCOPY OF PROXIMAL CHRONIC TOTAL OCCLUSION MICROCHANNELS USING THE SCANNING FIBER ENDOSCOPE
- DOI:
10.1016/s0735-1097(18)31592-4 - 发表时间:
2018-03-10 - 期刊:
- 影响因子:
- 作者:
Vivian Hou;Dmitry Levin;Carol Hagen;William L. Lombardi;Eric Seibel;John Petersen - 通讯作者:
John Petersen
Eric Seibel的其他文献
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{{ truncateString('Eric Seibel', 18)}}的其他基金
I-Corps: Reducing medical adhesive-related skin injuries while using high-adhesion tape
I-Corps:使用高粘性胶带减少医疗粘合剂相关的皮肤损伤
- 批准号:
2149741 - 财政年份:2022
- 资助金额:
$ 55万 - 项目类别:
Standard Grant
EAGER: Device for Prevention of Endotracheal Tube Biofilm Formation for the Prevention of Ventilator Associated Pneumonia
EAGER:预防气管插管生物膜形成的装置,用于预防呼吸机相关肺炎
- 批准号:
2033628 - 财政年份:2020
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$ 55万 - 项目类别:
Standard Grant
PFI:BIC - Smart Laser-Based Imaging and Optical Spectroscopy System: optical quantification of bacterial load, oral health surveillance, and caries prediction.
PFI:BIC - 基于智能激光的成像和光学光谱系统:细菌负荷的光学量化、口腔健康监测和龋齿预测。
- 批准号:
1631146 - 财政年份:2016
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$ 55万 - 项目类别:
Standard Grant
EAGER: Microendoscopy-Guided Biopsy in Very Small Ducts
EAGER:在非常小的导管中进行显微内窥镜引导活检
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1351110 - 财政年份:2013
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$ 55万 - 项目类别:
Standard Grant
EAGER: Complete 3D imaging of needle biopsy to diagnose pancreatic cancer
EAGER:完整的针活检 3D 成像诊断胰腺癌
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1212540 - 财政年份:2012
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$ 55万 - 项目类别:
Standard Grant
IDR-Collaborative: Quantitative 3D Optical Tomographic Microscopy for Lung Cancer Diagnosis
IDR-Collaborative:用于肺癌诊断的定量 3D 光学断层显微术
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1014976 - 财政年份:2010
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$ 55万 - 项目类别:
Standard Grant
SGER: Engineering a Mini-Pancreatoscope: An Endoscopic Optical Glidewire for the Direct Assessment of the Pancreatic Duct
SGER:设计微型胰腺镜:用于直接评估胰管的内窥镜光学滑线
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0809070 - 财政年份:2008
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$ 55万 - 项目类别:
Standard Grant
Wearable Low Vision Aids based upon Retinal Light Scanning Technologies
基于视网膜光扫描技术的可穿戴低视力辅助设备
- 批准号:
9978888 - 财政年份:2000
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$ 55万 - 项目类别:
Continuing Grant
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