SBIR Phase I: Automatic debridement device

SBIR第一期：自动清创装置

• 批准号: 2126854
• 负责人: Elad Taig
• 金额: $ 25.6万
• 依托单位: RAPHA ROBOTICS INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2126854&HistoricalAwards=false
• 关键词: SBIR; Phase; Automatic; debridement; device

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will be to improve the quality of life for the estimated 38 million people in the US, and 780 million people globally, who are suffering from nail fungus (onychomycosis), a $4.5 billion global opportunity. Onychomycosis is a serious health problem without a cure and affecting quality of life. Fungal nail infections contribute to the severity of diabetic foot problems and potentially leading to tissue necrosis and ultimately lower limb amputation. Current treatments have limited efficacy, often with serious side effects; oral medications may cause liver damage, and topical antifungal drugs and lasers have low efficacy due to their limited ability to penetrate the dense and variable thickness nail plate. This project will develop an autonomous robotic debridement device to reliably, precisely, and uniformly reduce the diseased nail thickness, which can be particularly effective in combination with laser or topical treatments for improved outcomes. This Small Business Innovation Research Phase I project will design, develop, and build an engineering prototype to demonstrate the feasibility of the novel conformal scan-based precise debridement treatment for onychomycosis. The technology offers precise and uniform polishing of the nail at the micron level, reducing the nail thickness down to its structural yet still safe limit. A 3D printing process will be developed for models used to validate design and demonstrate feasibility.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业创新研究（SBIR）第一阶段项目的更广泛的影响/商业潜力将改善美国估计3800万人的生活质量，全球7.8亿人患有指甲真菌（甲癣），这是一个45亿美元的全球机会。甲真菌病是一种严重的健康问题，无法治愈，影响生活质量。真菌性指甲感染导致糖尿病足问题的严重性，并可能导致组织坏死，最终导致下肢截肢。目前的治疗方法疗效有限，通常有严重的副作用;口服药物可能会导致肝损伤，局部抗真菌药物和激光由于穿透致密和厚度可变的指甲板的能力有限，疗效较低。该项目将开发一种自主机器人清创设备，以可靠，精确和均匀地减少患病指甲厚度，这与激光或局部治疗相结合，可以特别有效地改善结果。这个小企业创新研究第一阶段项目将设计，开发和建立一个工程原型，以证明新的适形扫描为基础的精确清创治疗甲癣的可行性。该技术提供精确和均匀的抛光指甲在微米级，减少指甲厚度下降到其结构，但仍然安全的限制。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。