STTR Phase I: Dermatologist-level detection of suspicious pigmented skin lesions from high-resolution full-body images

STTR 第一阶段：从高分辨率全身图像中对可疑色素性皮肤病变进行皮肤科医生级别的检测

• 批准号: 2127051
• 负责人: Davood Tashayyod
• 金额: $ 25.6万
• 依托单位: LUMO IMAGING LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2127051&HistoricalAwards=false
• 关键词: STTR; Phase; Dermatologist; level; detection

The broader impact/commercial potential of this Small Business Technology Transfer Program (STTR) Phase I project is to improve outcomes in dermatology and enable improved clinical care in the absence of specialists. The proposed technology enables cost-effective screening for cancer, psoriasis, atopic dermatitis, and other inflammatory skin conditions. In the United States, psoriasis affects about 8 million people while about 31.6 million people in the United States have some form of eczema, including atopic dermatitis. The proposed system generates a highly magnified image of the skin for analysis by a clinician or an artificial-intelligence based automated system. This Small Business Technology Transfer Program (STTR) Phase I project integrates several subsystems: 1) a scanner and software to capture and reconstruct super high-resolution (dermatoscope level) model of the entire skin surface of patients in a matter of minutes; 2) a multispectral illumination system to provide more information than currently available from a typical white-light systems, potentially leading to superior sensitivity and specify in lesion detection and classification; and 3) a system to find and classify lesions automatically from high-resolution images. This system advances the automated classification of images beyond those filtered previously by a clinician. Moreover, the system's UV illuminations system potentially can be used in a photodynamic treatment regimen.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业技术转让计划（STTR）第一阶段项目的更广泛的影响/商业潜力是改善皮肤病学的结果，并在没有专家的情况下改善临床护理。 该技术能够经济有效地筛查癌症、牛皮癣、特应性皮炎和其他炎症性皮肤病。在美国，银屑病影响约800万人，而美国约3160万人患有某种形式的湿疹，包括特应性皮炎。所提出的系统生成高度放大的皮肤图像，以供临床医生或基于人工智能的自动化系统进行分析。这个小企业技术转移计划（STTR）第一阶段项目集成了几个子系统：1）扫描仪和软件，以捕获和重建超高分辨率（皮肤镜级别）在几分钟内完成患者整个皮肤表面的模型; 2）多光谱照明系统以提供比当前从典型白光系统可获得的信息更多的信息，潜在地导致上级灵敏度并指定病变检测和分类;以及3）从高分辨率图像自动发现病变并对病变进行分类的系统。 该系统推进了图像的自动分类，超出了临床医生先前过滤的图像。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。