LEAPS-MPS: Confinement of Organometallic Complexes within Structured Polymers for Site-Isolated Tandem Catalysis

该奖项的全部或部分资金来自《2021年美国救援计划法案》(公法117-2)。该项目由数学和物理科学局资助，设在化学系，圣何塞州立大学(SJSU)的Madalyn Radlaer教授和她的学生将致力于开发可用于串联催化的新化学系统。串联催化，即两个或更多的催化剂串联操作，在一步中完成多个反应，提供了显著的效率和原子经济性，因为不需要像多步合成所需的工作或条件改变。开发串联催化系统的挑战是，两个反应的每个成分必须是相容的-催化剂、试剂、产品和溶剂-并且催化剂必须能够在相同的条件下发挥作用。拉德劳尔教授还将开展一项教育和指导计划，帮助在她的研究项目和她所在的SJSU(一所西班牙裔服务机构)的系中扩大在科学领域代表性不足的学生的参与。Radlaer正在解决串联催化的挑战，方法是利用星形聚合物的三维结构作为催化的支架，允许有机金属催化剂的位置隔离，保护这些高活性物种，从而允许使用不相容的催化剂进行串联催化。烷烃歧化反应因其作为绿色能源过程的潜力而被特别作为测试串联催化序列的目标。拉德劳尔教授建议扩大参与活动，包括向圣何塞州立大学(SJSU)和当地社区大学的URM学生提供跨学科的本科生研究体验。她还将参与为上海交通大学URM学生制定的辅导计划。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). In this project, funded by the Mathematical and Physical Sciences Directorate and housed in the Chemistry Division, Professor Madalyn Radlauer and her students at San Jose State University (SJSU) will work to develop new chemical systems that can be used for tandem catalysis. Tandem catalysis, in which two or more catalysts operate in tandem to enact multiple reactions in a single step, provides significant benefits to efficiency and atom economy, as no workup or change of conditions is needed as would be required for multistep syntheses. The challenge for developing tandem catalytic systems is that every component of both reactions must be compatible – catalysts, reagents, products, and solvents – and the catalysts must be able to function under the same conditions. Prof. Radlauer will also undertake an educational and mentoring program that will help broaden participation of students underrepresented in science, both in her research program and in her department at SJSU, which is a Hispanic Serving Institution.Prof. Radlauer is addressing the challenges of tandem catalysis by taking advantage of the three dimensional structure of star polymers to serve as scaffolds for catalysis, allowing for the site isolation of organometallic catalysts, shielding these highly reactive species, and thereby permitting tandem catalysis with incompatible catalysts. Alkane metathesis is specifically being targeted as a test tandem catalytic sequence for its potential as a green energy process. Prof. Radlauer proposes broadening participation activities that would include providing an interdisciplinary undergraduate research experience to URM students from San Jose State University (SJSU) and from local community colleges. She will also be involved in development of a mentoring program for URM students at SJSU.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.