LEAPS-MPS: Confinement of Organometallic Complexes within Structured Polymers for Site-Isolated Tandem Catalysis

LEAPS-MPS：将有机金属配合物限制在结构化聚合物中用于位点隔离串联催化

• 批准号: 2137584
• 负责人: Madalyn Radlauer
• 金额: $ 24.97万
• 依托单位: San Jose State University Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2137584&HistoricalAwards=false
• 关键词: LEAPS; MPS; Confinement; Organometallic; Complexes

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). In this project, funded by the Mathematical and Physical Sciences Directorate and housed in the Chemistry Division, Professor Madalyn Radlauer and her students at San Jose State University (SJSU) will work to develop new chemical systems that can be used for tandem catalysis. Tandem catalysis, in which two or more catalysts operate in tandem to enact multiple reactions in a single step, provides significant benefits to efficiency and atom economy, as no workup or change of conditions is needed as would be required for multistep syntheses. The challenge for developing tandem catalytic systems is that every component of both reactions must be compatible – catalysts, reagents, products, and solvents – and the catalysts must be able to function under the same conditions. Prof. Radlauer will also undertake an educational and mentoring program that will help broaden participation of students underrepresented in science, both in her research program and in her department at SJSU, which is a Hispanic Serving Institution.Prof. Radlauer is addressing the challenges of tandem catalysis by taking advantage of the three dimensional structure of star polymers to serve as scaffolds for catalysis, allowing for the site isolation of organometallic catalysts, shielding these highly reactive species, and thereby permitting tandem catalysis with incompatible catalysts. Alkane metathesis is specifically being targeted as a test tandem catalytic sequence for its potential as a green energy process. Prof. Radlauer proposes broadening participation activities that would include providing an interdisciplinary undergraduate research experience to URM students from San Jose State University (SJSU) and from local community colleges. She will also be involved in development of a mentoring program for URM students at SJSU.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项全部或部分由《2021年美国救援计划法案》（公法117-2）资助。在该项目中，由数学和物理科学理事会资助，位于化学部门，圣何塞州立大学（SJSU）的Madalyn Radlauer教授和她的学生将致力于开发可用于串联催化的新化学系统。串联催化是指两个或两个以上的催化剂串联作用，在一个步骤中产生多个反应，在效率和原子经济性方面具有显著的优势，因为不需要像多步骤合成那样进行后续处理或改变条件。开发串联催化系统的挑战在于两个反应的每个组分必须是相容的——催化剂、试剂、产物和溶剂——催化剂必须能够在相同的条件下起作用。Radlauer教授还将承担一项教育和指导计划，以帮助在她的研究项目和她在SJSU的西班牙裔服务机构的部门中扩大科学领域代表性不足的学生的参与。Radlauer正在解决串联催化的挑战，利用星形聚合物的三维结构作为催化支架，允许有机金属催化剂的位点隔离，屏蔽这些高活性物质，从而允许与不相容的催化剂进行串联催化。烷烃复分解是专门针对测试串联催化序列，因为它的潜力作为一个绿色能源过程。Radlauer教授建议扩大参与活动，包括为来自圣何塞州立大学（SJSU）和当地社区学院的URM学生提供跨学科的本科研究经验。她还将参与为上海大学URM学生制定的指导计划。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。