Cellular Backpacks: A fundamental investigation of cell-material interactions.

细胞背包：细胞与材料相互作用的基础研究。

• 批准号: 2138064
• 负责人: Omokolade Adebowale
• 金额: $ 30万
• 依托单位: Adebowale, Omokolade
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2138064&HistoricalAwards=false
• 关键词: Cellular; Backpacks; fundamental; investigation; cell

This award is made as part of the FY 2021 Mathematical and Physical Sciences Ascending Postdoctoral Research Fellowships (MPS-Ascend). Each fellowship supports a research and training project at a host institution in the mathematical and physical sciences, including applications to other disciplines, under the mentorship of a sponsoring scientist. This fellowship to Dr. Omokolade Adebowale supports his research project entitled " Cellular Backpacks: A fundamental investigation of cell-material interactions." The host institution for the fellowship is Harvard University, and the sponsoring scientist is Dr. Samir Mitragotri. Dr. Adebowale's research focuses in the study of how the physicochemical properties of cellular ‘backpacks’, and the biophysical properties of cell membranes, regulate cell-backpack interactions that lead to enhanced cellular functions. The ‘backpacks’ consist of two key structural components: a payload carrying region, and a cell-adhesion region. The goals are to optimize the mechanical and viscoelastic properties of the structural components, study how cell-membrane properties impact cell-backpack interactions, and to investigate how these properties mediate cellular functions. The outcomes of the research will be broadly disseminated through websites, social media, conferences, technical papers, and at the annual Cambridge Science Festival. The plan to broaden participation of underrepresented minority groups in mathematical and physical sciences includes partnering with graduate students and postdocs in the Boston-area to provide mentorship for undergraduates applying to graduate school.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项是作为2021财年数学和物理科学上升博士后研究奖学金（MPS-Ascend）的一部分。每项研究金在一名赞助科学家的指导下，支助在一个东道机构进行的数学和物理科学研究和培训项目，包括应用于其他学科。Omokolade Adebowale博士的奖学金支持他的研究项目“细胞背包：细胞-材料相互作用的基础研究”。“该研究金的主办机构是哈佛大学，赞助科学家是Samir Mitragotri博士。 Adebowale博士的研究重点是研究细胞“背包”的物理化学性质和细胞膜的生物物理性质如何调节细胞-背包相互作用，从而增强细胞功能。“背包”由两个关键的结构组成：有效载荷携带区和细胞粘附区。目标是优化结构组件的机械和粘弹性，研究细胞膜特性如何影响细胞-背包相互作用，并研究这些特性如何介导细胞功能。研究成果将通过网站、社交媒体、会议、技术论文和年度剑桥科学节广泛传播。该计划旨在扩大在数学和物理科学中代表性不足的少数群体的参与，包括与波士顿地区的研究生和博士后合作，为申请研究生院的本科生提供指导。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。