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CAREER: LUCO: A Noninvasive Miniaturized Blood Gas Sensor for Respiration Monitoring

职业：LUCO：用于呼吸监测的无创微型血气传感器

基本信息

批准号：
2143898
负责人：
Ulkuhan Guler
金额：
$ 50万
依托单位：
Worcester Polytechnic Institute
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-01 至 2027-04-30
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2143898&HistoricalAwards=false
关键词：
CAREER LUCO Noninvasive Miniaturized Blood

项目摘要

Among the vital signs of human health, respiratory parameters are key indicators of the physiological status of the human body. The accurate diagnosis of respiratory diseases mandates a measure of blood gases. The determination of blood gases requires an arterial blood sample, an invasive and painful process. This procedure, however, provides only a discrete measurement of respiratory efficacy during a rapidly changing situation. Transcutaneous monitoring is a noninvasive method of continuously measuring oxygen and carbon dioxide diffused through the skin, and any changes they undergo correlate closely with changes in blood gases. The contemporary methodology for measuring transcutaneous oxygen and carbon dioxide requires a heated sensor (that may burn the skin and require frequent alteration of the sensing spot) and a costly non-portable, bulky, corded sensing unit. This project will address a critical unmet need for a cost-effective noninvasive miniaturized wearable device capable of sensing multiple blood gas parameters that provide a comprehensive picture of one’s respiratory status from a home setting. The continuous and remote tracking of vital respiratory parameters will provide relevant and accurate data that alert a caregiver and influence the course of treatment. As the proposed system enables massive longitudinal blood gas data collected in non-clinical settings, clinicians and researchers can remotely assess and measure pulmonary outcomes objectively, and clinicians can further improve the home care management of patients with a fragile respiratory status. The educational program complementing this award will support STEM engagement in schools, provide research opportunities for underrepresented groups - particularly women, train students in state-of-the-art circuits and systems, biomedical, and optics, and support the future engineering workforce.This project will create a first-of-its-kind wearable blood gas monitor for managing the home care of individuals. More specifically, the core scientific contributions will include 1) the creation of a novel miniaturized custom-designed wearable sensor that measures two modalities of blood gases; 2) identification of factors affecting sensor readings such as temperature and drift for the self-calibration of blood gas sensors; 3) the exploration of innovative electronic interfaces for a specialized analog front-end for the proposed unique sensor with heterogeneous decay time, including one with an ultra-fast response; 4) determination of the feasibility and usability of the system during real-life activities in home settings by capturing the dynamic respiratory physiological status of individuals with longitudinal data. Having the ability to sense two vital respiratory parameters (namely, transcutaneous partial pressures of oxygen and carbon dioxide) with one wearable device is unique and superior to the current practice of measuring only oxygen saturation, and fills an important gap in the miniaturization of the transcutaneous blood gas sensor for noninvasive wearable device applications. In addition, the longitudinal new data will enable new biomedical research opportunities to assess therapies and further investigate medical conditions in which oxygen and carbon dioxide play a critical role, including novel respiratory diseases that are not yet fully understood (e.g., COVID-19). Progress on enabling the affordable and scalable remote monitoring of oxygenation and ventilation at home is transformative for prospective medical and scientific research.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在人体健康的生命体征中，呼吸参数是人体生理状态的关键指标。对呼吸系统疾病的准确诊断要求测量血气。测定血气需要动脉血样，这是一个有创而痛苦的过程。然而，在快速变化的情况下，这一程序只提供了对呼吸效率的离散测量。经皮监测是一种非侵入性的方法，可以持续测量通过皮肤扩散的氧气和二氧化碳，它们所经历的任何变化都与血气的变化密切相关。当代测量经皮氧气和二氧化碳的方法需要加热的传感器(这可能会灼伤皮肤，需要经常改变感应点)和昂贵的非便携式、笨重的有线传感单元。该项目将解决对具有成本效益的非侵入性小型化可穿戴设备的关键需求，该设备能够感知多个血气参数，提供家庭环境中一个人的呼吸状态的全面图像。对重要呼吸参数的持续和远程跟踪将提供相关和准确的数据，提醒护理人员并影响治疗过程。由于拟议的系统能够在非临床环境中收集海量纵向血气数据，临床医生和研究人员可以远程客观地评估和测量肺部结果，临床医生可以进一步改善对呼吸脆弱患者的家庭护理管理。作为该奖项的补充，教育项目将支持STEM在学校的参与，为代表不足的群体-特别是女性-提供研究机会，在最先进的电路和系统、生物医学和光学方面培训学生，并支持未来的工程劳动力。该项目将创造首个此类可穿戴式血气监测仪，用于管理个人的家庭护理。更具体地说，核心科学贡献将包括1)创建一种新型的小型化定制设计的可穿戴式传感器，该传感器可以测量两种形式的血气；2)确定影响传感器读数的因素，如温度和漂移，用于血气传感器的自我校准；3)为拟议的具有不同衰减时间的独特传感器探索创新的模拟前端电子接口，包括具有超快响应的传感器；4)通过捕获具有纵向数据的个人动态呼吸生理状态，确定该系统在现实生活中家庭活动中的可行性和可用性。使用一个可穿戴设备能够感知两个重要的呼吸参数(即经皮氧分压和二氧化碳分压)是独特的，优于目前仅测量氧饱和度的做法，并填补了经皮血气传感器在非侵入性可穿戴设备应用方面的一个重要空白。此外，纵向的新数据将使新的生物医学研究机会能够评估治疗方法，并进一步调查氧气和二氧化碳在其中发挥关键作用的医疗条件，包括尚未完全了解的新型呼吸道疾病(如新冠肺炎)。在实现可负担和可扩展的家庭氧合和通风远程监控方面的进展对未来的医学和科学研究具有变革性。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A Miniaturized Transcutaneous Carbon Dioxide Monitor Based on Dual Lifetime Referencing

基于双寿命参考的小型化经皮二氧化碳监测仪

DOI：
10.1109/biocas54905.2022.9948600
发表时间：
2022
期刊：
2022 IEEE Biomedical Circuits and Systems Conference (BioCAS
影响因子：
0
作者：
Tufan, Tuna B.;Guler, Ulkuhan
通讯作者：
Guler, Ulkuhan

A Miniaturized Prototype for Continuous Noninvasive Transcutaneous Oxygen Monitoring

用于连续无创经皮氧监测的小型化原型

DOI：
10.1109/biocas54905.2022.9948598
发表时间：
2022
期刊：
2022 IEEE Biomedical Circuits and Systems Conference (BioCAS
影响因子：
0
作者：
Kahraman, Burak;Vakhter, Vladimir;Costanzo, Ian;Bu, Guixue;Foroozan, Foroohar;Guler, Ulkuhan
通讯作者：
Guler, Ulkuhan

A Nonuniform Sampling Lifetime Estimation Technique for Luminescent Oxygen Measurements

发光氧测量的非均匀采样寿命估计技术