REU Site: A Summer Research Experience in Structural and Computational Biology and Biophysics

REU 网站：结构与计算生物学和生物物理学的夏季研究经历

• 批准号: 2150396
• 负责人: Nicholas Noinaj
• 金额: $ 39.84万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2150396&HistoricalAwards=false
• 关键词: REU; Site; Summer; Research; Experience

This REU Site award to Purdue University, located in West Lafayette, IN, will support the training of 10 students for 10 weeks during the summers of 2023- 2025. It is anticipated that a total of 30 students, primarily from schools with limited research opportunities or from an under-represented group, will be trained in the program. Students will participate in career and professional development events and workshops to prepare them for careers within the structural biology field in academia, industry, and government. Students will learn how research is conducted, the ethical and responsible conduct of research, how to disseminate their results to a general audience, and will present the results of their work at scientific conferences. Assessment of the program will be performed using the online SALG URSSA tool. Students will be tracked after the program in order to determine their career paths.This REU program is designed to establish a framework that integrates research projects aimed at studying the structure and function of macromolecules with in-depth workshops designed to provide theoretical and practical training in contemporary structural biology techniques and biophysical methods. Students will gain training in methods such as computational biology, X-ray crystallography, nuclear magnetic resonance spectroscopy, and cryo-electron microscopy. Each trainee will leave the program with a solid foundation and understanding of the various structural biology methods regardless of the expertise within their host lab. These discovery-driven studies provide the molecular blueprint for the atomic structures of biomolecules which fuels subsequent hypothesis-based research. Projects included in this proposal focus on the structure and function of membrane protein machineries involved in signaling and nutrient import, viral enzymes, cancer-related proteins, CRISPR-Cas machinery, transporter proteins, and whole viruses. This REU program is hosted by the Department of Biological Sciences. Students that are in their sophomore or junior year are encouraged to apply. Applications will be reviewed using a rubric that values academics, creativity, hard-work, perseverance, and diversity. More information about the program and the application process are available by visiting http://scbb.bio.purdue.edu/reu.html, or by contacting the PI (Nicholas Noinaj at [e-mail]) or the administrative assistant (Becky Harding at [e-mail]).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

位于印第安纳州西拉斐特的普渡大学将在2023年至2025年的夏季为10名学生提供为期10周的培训。预计总共有30名学生将接受该项目的培训，这些学生主要来自研究机会有限的学校或代表性不足的群体。学生将参加职业和专业发展活动和研讨会，为他们在学术界、工业界和政府的结构生物学领域的职业生涯做好准备。学生将学习如何进行研究，道德和负责任的研究行为，如何向普通受众传播他们的成果，并将在科学会议上展示他们的工作成果。该计划的评估将使用在线SALG URSSA工具进行。课程结束后，将对学生进行跟踪，以确定他们的职业道路。该REU计划旨在建立一个框架，将旨在研究大分子结构和功能的研究项目与深入的研讨会结合起来，旨在提供当代结构生物学技术和生物物理方法的理论和实践培训。学生将获得计算生物学、x射线晶体学、核磁共振波谱学和冷冻电子显微镜等方法的培训。无论其所在实验室的专业知识如何，每位学员都将在离开该项目时拥有坚实的基础和对各种结构生物学方法的理解。这些发现驱动的研究为生物分子的原子结构提供了分子蓝图，为后续的基于假设的研究提供了燃料。本课题主要研究方向为参与信号和营养输入的膜蛋白机制、病毒酶、癌症相关蛋白、CRISPR-Cas机制、转运蛋白和全病毒的结构和功能。该REU项目由生物科学系主办。我们鼓励大二或大三的学生申请。申请将以重视学术、创造力、勤奋、毅力和多样性的标准进行审查。有关该计划和申请流程的更多信息，请访问http://scbb.bio.purdue.edu/reu.html，或联系PI （Nicholas Noinaj: [e-mail]）或行政助理（Becky Harding: [e-mail]）。该奖项反映了美国国家科学基金会的法定使命，并通过基金会的智力价值和更广泛的影响审查标准进行评估，认为值得支持。