STTR Phase I: A Multimodal Integrated System For Improved Cardiopulmonary Resuscitation

该SBIR第一阶段项目旨在改善心脏骤停患者的预后。每年约有65万例心脏骤停，这是美国死亡率和发病率的首要原因，每年的院外费用估计为330亿美元。总体存活率一般保持在10%以下，患者往往会留下严重的神经损伤。手动心肺复苏术(CPR)仍然是最有效的治疗方法之一，结果比目前的技术更好。该项目将开发一种新的医疗设备，提供一种新的优越的自动CPR治疗系统。它结合了多种机械胸部按压的方法来改善患者复苏过程中的血流。该项目将推进临床前研究，开发第一个临床有效的无创自动CPR设备。该系统集成了提供机械CPR的多模式方法，因此相对于仅提供单一模式CPR的当前系统而言，这是一个重大进步。自动化和可编程的原型将确定方法和时机的最佳组合，以控制应用机械胸部按压以改善患者预后的多个泵机构。这个第一阶段的项目将在猪心脏骤停模型中进行优化研究，并开发一个概念验证模型。这些结果将为适合人类使用的下一代系统奠定基础，以及在CPR期间泵机制和心脏电生理学的血流动力学相互作用的先进研究成果。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This SBIR Phase I project aims to improve the outcomes of patients suffering sudden cardiac arrest. Approximately 650,000 cardiac arrests occur each year, representing the top reason for mortality and morbidity in the US and an estimated $33 billion a year for out-of-hospital costs. Overall survival remains generally below 10%, and patients are often left with significant neurological injury. Manual cardiopulmonary resuscitation (CPR) still remains one of the most effective treatments, resulting in better outcomes than current technologies. This project will develop a novel medical device that provides a novel superior automated CPR therapeutic system. It combines multiple methods of mechanical chest compression to improve patient blood flow during resuscitation.This project will advance preclinical research for developing the first clinically effective noninvasive automated CPR device. The system integrates a multimodal approach for delivering mechanical CPR, and therefore represents a significant advancement to current systems that only deliver a single mode of CPR. The automated and programmable prototype will determine the optimal combination of methods and timing, to control multiple pump mechanisms for applying mechanical chest compressions to improve patient outcomes. This Phase I project will conduct optimization studies in a swine model of cardiac arrest and develop a proof-of-concept model. These results will provide the foundation for the next generation system suitable for human use, as well as advance research results on the hemodynamic interactions of pump mechanisms and cardiac electrophysiology during CPR.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.