STTR Phase I: A Multimodal Integrated System For Improved Cardiopulmonary Resuscitation

STTR 第一阶段：用于改善心肺复苏的多模式集成系统

• 批准号: 2151541
• 负责人: Norman Paradis
• 金额: $ 25.6万
• 依托单位: CPR THERAPEUTICS INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2151541&HistoricalAwards=false
• 关键词: STTR; Phase; Multimodal; Integrated; System

This SBIR Phase I project aims to improve the outcomes of patients suffering sudden cardiac arrest. Approximately 650,000 cardiac arrests occur each year, representing the top reason for mortality and morbidity in the US and an estimated $33 billion a year for out-of-hospital costs. Overall survival remains generally below 10%, and patients are often left with significant neurological injury. Manual cardiopulmonary resuscitation (CPR) still remains one of the most effective treatments, resulting in better outcomes than current technologies. This project will develop a novel medical device that provides a novel superior automated CPR therapeutic system. It combines multiple methods of mechanical chest compression to improve patient blood flow during resuscitation.This project will advance preclinical research for developing the first clinically effective noninvasive automated CPR device. The system integrates a multimodal approach for delivering mechanical CPR, and therefore represents a significant advancement to current systems that only deliver a single mode of CPR. The automated and programmable prototype will determine the optimal combination of methods and timing, to control multiple pump mechanisms for applying mechanical chest compressions to improve patient outcomes. This Phase I project will conduct optimization studies in a swine model of cardiac arrest and develop a proof-of-concept model. These results will provide the foundation for the next generation system suitable for human use, as well as advance research results on the hemodynamic interactions of pump mechanisms and cardiac electrophysiology during CPR.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

SBIR一期项目旨在改善心脏骤停患者的预后。每年大约发生65万例心脏骤停，这是美国死亡率和发病率的首要原因，据估计，每年的院外费用为330亿美元。总体生存率通常低于10%，患者常留下严重的神经损伤。人工心肺复苏术（CPR）仍然是最有效的治疗方法之一，其结果比目前的技术要好。本项目将开发一种新型医疗设备，提供一种新型的高级自动心肺复苏术治疗系统。它结合了多种机械胸部按压方法，以改善复苏过程中患者的血液流动。该项目将推进临床前研究，以开发第一个临床有效的无创自动心肺复苏术设备。该系统集成了提供机械心肺复苏的多模式方法，因此代表了当前只能提供单一模式心肺复苏的系统的重大进步。自动化和可编程的原型将确定方法和时间的最佳组合，以控制多个泵机制，应用机械胸外按压，以改善患者的预后。这个第一阶段的项目将在猪心脏骤停模型中进行优化研究，并开发一个概念验证模型。这些结果将为下一代适合人类使用的系统提供基础，并推进心肺复苏术中泵机制和心脏电生理血流动力学相互作用的研究成果。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。