Cavity-Containing Supramolecular Gels as a Tool for Orthogonal Self-assembly Crystallization Processes

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The aim of this project is to establish orthogonal self-assembly crystallization processes in which gelator and crystallization system form a weakly coupled arrangement. This technique of non-equilibrium orthogonal self-assembly crystallization offers great advantages as it provides a high surface area of exposed gel fibres where the crystal growth occurs through a diffusion and nucleation-controlled process. For these new low molecular weight supramolecular gels containing bowl-shaped molecules will be synthesized and their gel formation behavior as well as its reversibility by external stimuli will be studied. These gels will be engaged for orthogonal self-assembly crystallization processes which have the potential to become a new tool in pharmaceutical polymorph screening by use of the active surface of the gel fibres to control the nucleation of the drug solid form.