Cavity-Containing Supramolecular Gels as a Tool for Orthogonal Self-assembly Crystallization Processes

本项目旨在建立凝胶与结晶体系形成弱耦合排列的正交自组装结晶工艺。这种非平衡正交自组装结晶技术具有很大的优势，因为它提供了暴露凝胶纤维的高表面积，晶体生长通过扩散和成核控制过程发生。为此，我们将合成含有碗状分子的新型低分子量超分子凝胶，并对其凝胶形成行为及其在外界刺激下的可逆性进行研究。这些凝胶将用于正交自组装结晶过程，通过使用凝胶纤维的活性表面来控制药物固体形式的成核，这有可能成为药物多晶筛选的新工具。

The aim of this project is to establish orthogonal self-assembly crystallization processes in which gelator and crystallization system form a weakly coupled arrangement. This technique of non-equilibrium orthogonal self-assembly crystallization offers great advantages as it provides a high surface area of exposed gel fibres where the crystal growth occurs through a diffusion and nucleation-controlled process. For these new low molecular weight supramolecular gels containing bowl-shaped molecules will be synthesized and their gel formation behavior as well as its reversibility by external stimuli will be studied. These gels will be engaged for orthogonal self-assembly crystallization processes which have the potential to become a new tool in pharmaceutical polymorph screening by use of the active surface of the gel fibres to control the nucleation of the drug solid form.