Cavity-Containing Supramolecular Gels as a Tool for Orthogonal Self-assembly Crystallization Processes

含空腔超分子凝胶作为正交自组装结晶过程的工具

• 批准号: 250805915
• 负责人: Dr. Lena Kaufmann
• 金额: --
• 依托单位: Department of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/250805915?language=en
• 关键词: Cavity; Containing; Supramolecular; Gels; Tool

The aim of this project is to establish orthogonal self-assembly crystallization processes in which gelator and crystallization system form a weakly coupled arrangement. This technique of non-equilibrium orthogonal self-assembly crystallization offers great advantages as it provides a high surface area of exposed gel fibres where the crystal growth occurs through a diffusion and nucleation-controlled process. For these new low molecular weight supramolecular gels containing bowl-shaped molecules will be synthesized and their gel formation behavior as well as its reversibility by external stimuli will be studied. These gels will be engaged for orthogonal self-assembly crystallization processes which have the potential to become a new tool in pharmaceutical polymorph screening by use of the active surface of the gel fibres to control the nucleation of the drug solid form.

本研究旨在建立凝胶因子与结晶系统形成弱耦合排列的正交自组装结晶过程。这种非平衡正交自组装结晶技术提供了很大的优势，因为它提供了暴露的凝胶纤维的高表面积，其中晶体生长通过扩散和成核控制过程发生。针对这些新的低分子量的含碗状分子的超分子凝胶，我们将合成它们，并研究它们的凝胶形成行为及其在外界刺激下的可逆性。这些凝胶将从事正交自组装结晶过程，有可能成为一个新的工具，在药物多晶型筛选通过使用凝胶纤维的活性表面，以控制药物固体形式的成核。