CAS: Dialing-In Sonochemical Synthesis of Transition Metal Precatalysts

在化学部化学合成（SYN）项目的支持下，中佛罗里达大学化学系的Titel Jurca正在开发可持续的方法来合成化学工业中用作催化剂的金属化合物。催化剂是一种可以加速化学反应的物质，在许多重要过程中对减少消耗和废物产生至关重要。然而，催化剂本身通常是以不环保的方式制备的。本项目的重点是利用超声波辐照在单步工艺中产生催化剂，所用的溶剂、时间和能量只占传统制备所需的一小部分。在这个项目下训练的学生将获得最先进的化学技术的专业知识。此外，他们将接受绿色和可持续技术方面的培训，在那里他们将发展评估和设计可持续化学过程的专门知识。本项目将开发广泛应用的希夫碱配体及其配合物的超声辅助合成方案。该项目有五个主要目标：(i)描述温度、声强、浓度和覆盖气体对一锅声化学合成双（亚）吡啶配体、-二亚胺及其相应的过渡金属化合物的影响；（ii）将反应方案扩展到声化学合成非对称双（亚）吡啶配体、-二亚胺及其相应的过渡金属化合物；（iii）发展一锅声化学路线，以制备栓系、多齿配体及双金属过渡金属配合物；（iv）利用前面任务中合成的预催化剂优化催化硼氢化的声化学条件；（iv）评估声化学与传统溶液合成的绿色化学指标。在实现研究目标的同时，该项目还将致力于为下一代催化科学家制定培训和推广计划，重点是为服务不足的少数族裔社区成员提供机会。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

With the support of the Chemical Synthesis (SYN) Program of the Chemistry Division, Titel Jurca of the Department of Chemistry at the University of Central Florida is developing sustainable ways to synthesize metal compounds that are used as catalysts by the chemical industry. Catalysts are species that can accelerate chemical reactions and are critical for reducing consumption and waste formation during many important processes. However, the catalysts themselves are often prepared in an environmentally unfriendly fashion. This project focuses on utilizing ultrasonic irradiation to generate catalysts in a single-step process using a fraction of the solvent, time, and energy input required for the conventional preparations. Students trained under this program will gain expertise in state-of-the-art chemical techniques. In addition, they will be trained in green and sustainable technologies, where they will develop expertise in the assessment and design of sustainable chemical processes.This project will develop protocols for the ultrasonic-assisted synthesis of broadly utilized Schiff-base ligands, and their coordination complexes. The project has five key aims: (i) to delineate the effects of temperature, acoustic intensity, concentration, and cover gas for the one-pot sonochemical synthesis of bis(imino)pyridine ligands, -diimine, and their respective transition metal compounds; (ii) to extend the reaction protocols towards the sonochemical synthesis of non-symmetric bis(imino)pyridine ligands, -diimine and their respective transition metal compounds; (iii) to develop one-pot sonochemical routes for tethered, multi-dentate ligands and bimetallic transition metal complexes; (iv) to optimize the sonochemical conditions for catalytic hydroboration utilizing the precatalysts synthesized in the previous tasks and (iv) to assess the green chemistry metrics for sonochemical vs. conventional solution-based synthesis. In parallel to the research goals, the PI will work to develop a training and outreach program for the next generation of catalysis scientists, with a focus on providing opportunities to members of underserved minority communities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.