Understanding the molecular machinery driving basic cellular processes with relevance to the pathogenesis of cancer and auto immune disorders

了解驱动与癌症和自身免疫性疾病发病机制相关的基本细胞过程的分子机制

• 批准号: 250873790
• 负责人: Professor Dr. Krishnaraj Rajalingam
• 金额: --
• 依托单位: Forschungszentrum für Immuntherapie (FZI)
• 依托单位国家: 德国
• 项目类别: Heisenberg Professorships
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/250873790?language=en
• 关键词: Understanding; molecular; machinery; driving; basic

The precondition for a Heisenberg Programme funding is high scientific quality and originality of the research project at international level and suitability for further qualification as a university teacher. Applicants need to meet all the requirements for appointment to a permanent professorship.The aim of this programme is to enable outstanding scientists to prepare for a scientific leadership function, and simultaneously work on further research topics. This research does not necessarily need to be planned and carried out in the form of a project.For this reason, and unlike the procedure in other funding programmes, both the abstracts of applications and final reports are not required and will therefore not be published in GEPRIS.

海森堡计划资助的先决条件是研究项目具有国际水平的高科学质量和原创性以及适合进一步获得大学教师资格。申请人需要满足任命为常任教授的所有要求。该项目的目的是让杰出的科学家为担任科学领导职务做好准备，同时致力于进一步的研究课题。这项研究不一定需要以项目的形式进行规划和实施。因此，与其他资助计划的程序不同，不需要申请摘要和最终报告，因此不会在 GEPRIS 上发布。

项目成果

Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas

• DOI: 10.1038/s41467-020-15955-w
• 发表时间: 2020-04-28
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Krishnan, Aswini;Berthelet, Jean;Rajalingam, Krishnaraj
• 通讯作者: Rajalingam, Krishnaraj

ERK3/MAPK6 controls IL-8 production and chemotaxis

• DOI: 10.7554/elife.52511
• 发表时间: 2020-04-21
• 期刊: ELIFE
• 影响因子: 7.7
• 作者: Bogucka, Katarzyna;Pompaiah, Malvika;Rajalingam, Krishnaraj
• 通讯作者: Rajalingam, Krishnaraj

Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours

• DOI: 10.1038/onc.2017.93
• 发表时间: 2017-08-17
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Yurugi, H.;Marini, F.;Rajalingam, K.
• 通讯作者: Rajalingam, K.

RAF kinases are stabilized and required for dendritic cell differentiation and function

• DOI: 10.1038/s41418-019-0416-4
• 发表时间: 2019-09
• 期刊: Cell Death and Differentiation
• 影响因子: 12.4
• 作者: Kristina Riegel;J. Schlöder;Marco Sobczak;H. Jonuleit;B. Thiede;H. Schild;K. Rajalingam