New Strategies for the Synthesis of Complex, Polycyclic Molecules

合成复杂多环分子的新策略

• 批准号: 2154665
• 负责人: Corinna Schindler
• 金额: $ 51.76万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2154665&HistoricalAwards=false
• 关键词: New; Strategies; Synthesis; Complex; Polycyclic

With this award, the Chemical Synthesis program of the Division of Chemistry is supporting the research of Professor Corinna Schindler at the University of Michigan to develop new strategies for the synthesis of naturally occurring molecules that hold great promise due to their biological activity. The selective synthesis of complex, polycyclic structures remains challenging as the majority of currently available methodologies have been developed for simple molecular scaffolds. Consequently, more complex structures often fail to react. The research described seeks to advance sustainable synthetic strategies relying on either the recognition of hidden symmetry elements or visible light photocatalysis to greatly simplify access to these desirable compounds of biological importance. This research focus is an integral component of the principal investigator’s educational plans which include training opportunities for undergraduate and graduate students, both in large introductory science classes and in her research laboratory, as well as outreach programs designed to engage Detroit elementary school girls, middle school students, and the general public to spark and sustain an interest in scientific research. The overarching goal of Professor Schindler’s research program is to address the challenge of selective carbon-carbon bond formation in complex systems. The studies proposed will establish new synthetic approaches to enable direct access to four classes of important complex, polycyclic molecules of biological importance. Specifically, two distinct objectives will be pursued that (i) build on and develop hidden symmetry elements as an enabling design element in complex molecule synthesis and (ii) advance visible light-mediated [2+2]-cycloadditions to rapidly access strained, polycyclic systems incorporating four-membered rings. Together, these new strategies are expected to (iii) enable the synthesis of desirable biologically active complex, polycyclic molecules. The objectives described seek to complement and advance currently existing synthetic methods to enable rapid and efficient access to carbocyclic structures of biological importance.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

有了这个奖项，化学系的化学合成计划正在支持密歇根大学Corinna Schindler教授的研究，以开发合成天然分子的新策略，这些分子由于其生物活性而具有很大的前景。复杂的多环结构的选择性合成仍然具有挑战性，因为大多数目前可用的方法已经开发用于简单的分子支架。因此，更复杂的结构往往无法反应。所描述的研究旨在推进可持续的合成策略，该策略依赖于对隐藏的对称元素或可见光的识别，以极大地简化对这些具有生物重要性的理想化合物的获取。这项研究重点是主要研究者的教育计划，其中包括本科生和研究生的培训机会，无论是在大型入门科学类和她的研究实验室，以及旨在从事底特律小学女生，中学生和公众的推广计划的一个组成部分，以激发和维持对科学研究的兴趣。辛德勒教授的研究计划的总体目标是解决复杂系统中选择性碳-碳键形成的挑战。拟议的研究将建立新的合成方法，使直接获得四类重要的复杂，多环分子的生物学意义。具体而言，将追求两个不同的目标，即（i）建立和发展隐藏的对称元素作为复杂分子合成中的一个使能设计元素，以及（ii）推进可见光介导的[2+2]-环加成反应，以快速获得应变，多环系统，包括四元环。总之，这些新的策略，预计（iii）能够合成所需的生物活性的复杂，多环分子。所描述的目标旨在补充和推进现有的合成方法，使快速和有效地获得具有生物重要性的碳环结构。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。