Collaborative Research: Electrochemical Ni-Catalyzed Reductive Biaryl Coupling: Mechanistic Studies to Enable Chemical Synthesis
合作研究:电化学镍催化还原联芳基偶联:实现化学合成的机理研究
基本信息
- 批准号:2154699
- 负责人:
- 金额:$ 18.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
With the support of the Chemical Catalysis program in the Division of Chemistry, a collaborative team including Daniel Weix and Shannon Stahl of the University of Wisconsin-Madison, Mohammad Rafiee of the University of Missouri-Kansas City, and Robert Paton of Colorado State University are studying new approaches toward the electrochemical synthesis of chemicals useful in polymers and agriculture. This collaborative project will use analytical and computational tools to shed light on how these reactions occur and what factors are important for success. The lessons learned will enable lower-cost, greener synthesis of important molecules using electricity in place of metal reductants. The research team will also work to improve equal representation in chemistry via several established Bridge and outreach programs. Finally, the team will teach the broader chemistry community about the new tools of organic electrochemistry through courses and short courses.This collaborative team from the University of Wisconsin-Madison, the University of Missouri-Kansas City, and Colorado State University is studying electrochemistry-driven nickel catalyzed reductive biaryl synthesis from a variety of aryl electrophiles. The research team will use a combination of stoichiometric organonickel studies, theory, and electroanalytical techniques to understand how each step in the biaryl synthesis (oxidative addition, transmetalation, reduction, and reductive elimination) is influenced by catalyst identity, conditions, and applied potential. This understanding will be used to drive further studies to improve catalyst turnover number, turnover frequency, and selectivity, including the development of cross-selective reactions, to make electrochemical reductive biaryl synthesis suitable for commercial scale-up in flow reactors. These studies will contribute to an improved understanding of nickel catalysis and electrosynthesis and the resulting reactions will be lower-cost, more green alternatives to the state-of-the-art biaryl syntheses that utilize unselective oxidation reactions, expensive precious metal catalysts, and reactive aryl nucleophiles.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在化学系化学催化项目的支持下,包括威斯康星大学麦迪逊分校的Daniel Wex和Shannon Stahl,密苏里大学堪萨斯城分校的Mohammad Rafiee和科罗拉多州立大学的Robert Paton在内的一个合作小组正在研究用于聚合物和农业的化学物质的电化学合成的新方法。这个合作项目将使用分析和计算工具来阐明这些反应是如何发生的,以及哪些因素对成功很重要。吸取的经验教训将使使用电力代替金属还原剂以更低的成本、更环保的方式合成重要的分子成为可能。研究小组还将通过几个既定的桥梁和外联计划,努力改善化学中的平等代表权。最后,该团队将通过课程和短期课程向更广泛的化学界传授有机电化学的新工具。这个来自威斯康星大学麦迪逊分校、密苏里大学堪萨斯城分校和科罗拉多州立大学的合作小组正在研究电化学驱动的镍催化还原联芳基从各种芳基亲电分子合成。研究小组将结合化学计量有机镍研究、理论和电分析技术来了解联芳基合成中的每一步(氧化加成、金属易位、还原和还原消除)是如何受到催化剂特性、条件和应用潜力的影响的。这一认识将被用来推动进一步的研究,以提高催化剂的周转次数、周转频率和选择性,包括开发交叉选择反应,使电化学还原联芳合成适合在流动反应器中进行工业放大。这些研究将有助于更好地理解镍催化和电合成,所产生的反应将是使用非选择性氧化反应、昂贵的贵金属催化剂和活性芳基亲核试剂的最先进的联芳基合成的低成本、更绿色的替代品。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert Paton其他文献
Managing the aftermath:: Lessons from The Royal Bank of Scotland’s acquisition of NatWest
- DOI:
10.1016/j.emj.2006.04.001 - 发表时间:
2006-10-01 - 期刊:
- 影响因子:
- 作者:
Graham Kennedy;David Boddy;Robert Paton - 通讯作者:
Robert Paton
Robert Paton的其他文献
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{{ truncateString('Robert Paton', 18)}}的其他基金
Discovering Modular Catalysts for Selective Synthesis with Computation
通过计算发现用于选择性合成的模块化催化剂
- 批准号:
2400056 - 财政年份:2024
- 资助金额:
$ 18.01万 - 项目类别:
Standard Grant
Discovering Modular Catalysts for Asymmetric Synthesis with Computation
通过计算发现用于不对称合成的模块化催化剂
- 批准号:
1955876 - 财政年份:2020
- 资助金额:
$ 18.01万 - 项目类别:
Standard Grant
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Research on Quantum Field Theory without a Lagrangian Description
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Cell Research
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Cell Research (细胞研究)
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- 批准年份:2007
- 资助金额:45.0 万元
- 项目类别:面上项目
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