Synergy in a Solvent-Restrained Environment: Mechanochemical Control of Synthesis and Applications to Catalysis

溶剂限制环境中的协同作用:合成的机械化学控制及其催化应用

基本信息

  • 批准号:
    2155144
  • 负责人:
  • 金额:
    $ 52.46万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-01 至 2025-08-31
  • 项目状态:
    未结题

项目摘要

With the support of the Chemical Synthesis Program of the Chemistry Division, Professor Timothy Hanusa of Vanderbilt University will explore reactions that occur through grinding or ball milling. Chemical reactions are often performed in solvents that are toxic and/or environmentally unfriendly. Thus, there are a number of reasons why reducing solvent use could be of advantage. This project addresses the problem by developing a mechanical approach (mechanochemistry) to run chemical reactions with little or no solvent. Mechanochemistry involves grinding solid reactants together so that they are in intimate contact and the milling process provides the energy required to initiate and maintain the reaction between reactants. Mechanochemistry is a relatively undeveloped area and this research will work to find optimal conditions for such reactions. Targeted products include biodegradable polymers, a class of compounds of broad academic and industrial interests. Students involved in this project will gain insight and experience in mechanochemical methodology, a significant departure from the solvent-based orientation of most synthetic chemistry approaches. In addition, Professor Hanusa works closely with the Fisk-Vanderbilt Masters-to-Ph.D. Bridge Program, which is designed to broaden the participation of women and underrepresented minorities in science through partnerships between Vanderbilt and Historically Black Colleges and Universities. This project will study how the introduction of small amounts of liquid—too little to dissolve the reagents—influences mechanochemical reaction outcomes. A modification of this “liquid-assisted grinding” (LAG) technique will employ solid solvated reagents (“solvate-assisted grinding”, such as using the solid pyridine adduct [Ni(py)₄Cl₂] instead of NiCl₂ and liquid pyridine). Both main-group and transition metal coordination complexes and organometallic compounds will be studied. The research will also examine the effect of the lattice structures of solid reagents on mechanochemical reactivity. In addition to training of students, the project will provide educational and outreach efforts for women, members of underserved groups, and middle and high school students. An example is Professor Hanusa’s leadership role in the Fisk-Vanderbilt Masters-to-Ph.D. Bridge Program, which facilitates the entry and success of Master’s degree students into the Ph.D. program at Vanderbilt.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在化学系化学合成项目的支持下,范德比尔特大学的蒂莫西·哈努萨教授将探索通过研磨或球磨发生的反应。化学反应通常在有毒和/或环境不友好的溶剂中进行。因此,有许多原因可以说明为什么减少溶剂的使用是有利的。该项目通过开发一种机械方法(机械化学)来解决这个问题,以在很少或没有溶剂的情况下进行化学反应。机械化学涉及将固体反应物研磨在一起,使得它们紧密接触,并且研磨过程提供引发和维持反应物之间的反应所需的能量。机械化学是一个相对不发达的领域,这项研究将努力寻找这种反应的最佳条件。 目标产品包括可生物降解的聚合物,一类具有广泛学术和工业利益的化合物。参与该项目的学生将获得机械化学方法的洞察力和经验,这与大多数合成化学方法的溶剂基方向有很大不同。此外,哈努萨教授还与菲斯克-范德比尔特硕士至博士学位密切合作桥梁方案,旨在通过范德比尔特和历史上的黑人学院和大学之间的伙伴关系,扩大妇女和代表性不足的少数群体对科学的参与。本计画将研究引入少量液体(太少而无法溶解试剂)如何影响机械化学反应的结果。这种“液体辅助研磨”(LAG)技术的改进将采用固体溶剂化试剂(“溶剂化物辅助研磨”,例如使用固体吡啶加合物[Ni(py)Cl Cl Cl]代替NiCl Cl Cl和液体吡啶)。主族和过渡金属配位络合物和有机金属化合物将被研究。研究还将考察固体试剂的晶格结构对机械化学反应性的影响。除了对学生进行培训外,该项目还将为妇女、得不到充分服务的群体成员以及初中和高中学生提供教育和外联工作。一个例子是哈努萨教授在菲斯克-范德比尔特硕士到博士学位项目中的领导作用。桥梁计划,这有利于硕士学位的学生进入博士学位和成功。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Heteroleptic Aluminum Allyls as Initiators for Lactide Polymerization
杂配烯丙基铝作为丙交酯聚合引发剂
  • DOI:
    10.1021/acs.organomet.2c00482
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    Wenger, Lauren E.;Shawver, Nicholas M.;Brennessel, William W.;Long, Brian K.;Hanusa, Timothy P.
  • 通讯作者:
    Hanusa, Timothy P.
Correction to “Heteroleptic Aluminum Allyls as Initiators for Lactide Polymerization”
对“杂配烯丙基铝作为丙交酯聚合引发剂”的修正
  • DOI:
    10.1021/acs.organomet.2c00621
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    Wenger, Lauren E.;Shawver, Nicholas M.;Koby, Ross F.;Brennessel, William W.;Long, Brian K.;Hanusa, Timothy P.
  • 通讯作者:
    Hanusa, Timothy P.
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Timothy Hanusa其他文献

Timothy Hanusa的其他文献

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{{ truncateString('Timothy Hanusa', 18)}}的其他基金

Highly Active Mechanochemically Generated Main Group and Lanthanide Complexes
高活性机械化学生成的主族和镧系配合物
  • 批准号:
    1665327
  • 财政年份:
    2017
  • 资助金额:
    $ 52.46万
  • 项目类别:
    Standard Grant
Main Group and Lanthanide Elements in Controlled Coordination Environments: Synthesis, Structures, and Applications to Catalysis
受控配位环境中的主族和镧系元素:合成、结构和催化应用
  • 批准号:
    1112181
  • 财政年份:
    2011
  • 资助金额:
    $ 52.46万
  • 项目类别:
    Standard Grant
Functional Design for Reactive Alkali and Alkaline-earth Allyl Complexes
活性碱和碱土烯丙基配合物的功能设计
  • 批准号:
    0616880
  • 财政年份:
    2006
  • 资助金额:
    $ 52.46万
  • 项目类别:
    Standard Grant
Alkaline-Earth Complexes with Reactive Metal-Element Bonds
具有活性金属元素键的碱土配合物
  • 批准号:
    9528833
  • 财政年份:
    1996
  • 资助金额:
    $ 52.46万
  • 项目类别:
    Continuing Grant

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