FOR 2177: Integrated Chemical Micro Laboratories

微型化体系中的化学是一个非常活跃的研究领域，其中(生物)化学过程位于微通道或微腔中。近年来，在微反应技术以及分析方法和技术的小型化方面取得了令人印象深刻的科学进步。尽管世界各地都在这些单一学科上进行了密集的研究，但它们的有效结合在很大程度上仍处于初级阶段。研究单位“集成化学微实验室(In-Chem)”的目的是迎接这一特殊挑战，并协同弥合(生物)有机合成中的热门方法与微系统中的化学分析之间的差距。为了实现这一跨学科的目标，一组科学家在芯片或微型反应堆中进行(生物)化学转化领域的基础研究。一个突出的焦点是将化学合成与分析技术相结合，以在线实时表征过程。通过来自(生物)化学的分析和以合成为导向的学科的经验丰富的科学家的密切合作，综合合成和分析实验室领域有望取得重大进展。这种创新的潜在应用领域可以在药物发现、物质库组装、催化反应控制和反应机理阐明等领域做出贡献。由于在实验室芯片技术、分析化学和合成(生物)有机化学领域有强大的地区性专家集群，莱比锡-柏林研究区代表着致力于应对这些科学挑战的地区性重点研究单位的近乎理想的基础。

Chemistry in miniaturized systems in which (bio)-chemical processestake place in microchannels or cavities is a very active field ofresearch. In recent years, impressive scientific progress has beenachieved in micro reaction technology as well as in the miniaturizationof analytical methods and technologies. Despite intense researchefforts are made in these single disciplines all around the world, theirefficient combination is still largely in its infancy. The intention of theresearch unit “Integrated Chemical Micro Laboratories (In-CheM)” isto meet this particular challenge and to synergistically bridge the gapbetween highly topical approaches in (bio)-organic synthesis andchemical analysis in micro systems. To achieve this interdisciplinarygoal, a team of scientists performs fundamental research in the fieldsof (bio-) chemical transformations in chips or micro reactors. A strongfocus is the combination of chemical synthesis with analyticaltechniques to inline characterize the processes in real-time. By closecooperation of experienced scientists from analytics and synthesisoriented disciplines of (bio-) chemistry, significant progress in the areaof integrated synthesis and analysis labs is expected. Prominentapplication fields of such innovation can contribute in the field of, forexample, drug discovery, assembly of substance libraries, control ofcatalytic reactions and the elucidation of reaction mechanism.Attributed to the strong regional cluster of experts in the fields of labon-a-chip technology, analytical chemistry and synthetic (bio-) organicchemistry, the research area Leipzig-Berlin represents an almost idealbasis for a regionally focused research unit dedicated to meet thesescientific challenges.