Role of Ena/VASP proteins in vessel branching and vascular repair (A08)

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We have demonstrated an important role of the Ena/VASP proteins in leukocyte-endothelial cell communication, angiogenesis and vascular repair. However, underlying molecular mechanisms and the role of the Ena/VASP proteins in pathologic conditions, such as atherosclerosis, are elusive. Here, we aim to determine the molecular mechanisms and the physiological relevance of Ena/VASP-regulated receptor trafficking and guidance cue signalling in angiogenesis and atherosclerosis.